Overview
| Uniprot ID | Q6ZMU5 |
|---|
| Protein Name | Tripartite motif-containing protein 72 |
|---|
| Gene Name | TRIM72 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 398 |
LEAHVEAKEPRALRS |
Function
Muscle-specific E3 ubiquitin-protein ligase that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites (PubMed:36944613). Its ubiquitination activity is mediated by E2 ubiquitin-conjugating enzymes UBE2D1, UBE2D2 and UBE2D3 (By similarity). Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site (By similarity). This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation (By similarity). Probably acts upstream of the Ca(2+)-dependent membrane resealing process (By similarity). Required for transport of DYSF to sites of cell injury during repair patch formation (By similarity). Regulates membrane budding and exocytosis (By similarity). May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity)
Protein Sequence
10
MSAAPGLLHQ
20
ELSCPLCLQL
30
FDAPVTAECG
40
HSFCRACLGR
50
VAGEPAADGT
60
VLCPCCQAPT
70
RPQALSTNLQ
80
LARLVEGLAQ
90
VPQGHCEEHL
100
DPLSIYCEQD
110
RALVCGVCAS
120
LGSHRGHRLL
130
PAAEAHARLK
140
TQLPQQKLQL
150
QEACMRKEKS
160
VAVLEHQLVE
170
VEETVRQFRG
180
AVGEQLGKMR
190
VFLAALEGSL
200
DREAERVRGE
210
AGVALRRELG
220
SLNSYLEQLR
230
QMEKVLEEVA
240
DKPQTEFLMK
250
YCLVTSRLQK
260
ILAESPPPAR
270
LDIQLPIISD
280
DFKFQVWRKM
290
FRALMPALEE
300
LTFDPSSAHP
310
SLVVSSSGRR
320
VECSEQKAPP
330
AGEDPRQFDK
340
AVAVVAHQQL
350
SEGEHYWEVD
360
VGDKPRWALG
370
VIAAEAPRRG
380
RLHAVPSQGL
390
WLLGLREGKI
400
LEAHVEAKEP
410
RALRSPERRP
420
TRIGLYLSFG
430
DGVLSFYDAS
440
DADALVPLFA
450
FHERLPRPVY
460
PFFDVCWHDK
470
GKNAQPLLLV
GPEGAEA
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0030659 |
cytoplasmic vesicle membrane |
| Cellular Component |
GO:0042383 |
sarcolemma |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0031435 |
mitogen-activated protein kinase kinase kinase binding |
| Molecular Function |
GO:0001786 |
phosphatidylserine binding |
| Molecular Function |
GO:0031624 |
ubiquitin conjugating enzyme binding |
| Molecular Function |
GO:0061630 |
ubiquitin protein ligase activity |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0006887 |
exocytosis |
| Biological Process |
GO:0045087 |
innate immune response |
| Biological Process |
GO:0007517 |
muscle organ development |
| Biological Process |
GO:0003012 |
muscle system process |
| Biological Process |
GO:0001778 |
plasma membrane repair |
| Biological Process |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process |
GO:0051260 |
protein homooligomerization |
Reference
[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.