Search Results

Overview

Uniprot IDQ6ZRS2
Protein NameChromatin remodeling protein SRCAP
Gene NameSRCAP
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1003 RMLQPVPKQEGRTVV
3153 GGSPGLAKRGRLQPP

Function

Acts both as a chromatin remodeler and transcription coregulator. Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes expression through chromatin remodeling (PubMed:16634648, PubMed:17617668). Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription (PubMed:10347196, PubMed:11522779, PubMed:14500758, PubMed:16024792)

Protein Sequence

10 MQSSPSPAHP 20 QLPVLQTQMV 30 SDGMTGSNPV 40 SPASSSSPAS 50 SGAGGISPQH 60 IAQDSSLDGP 70 PGPPDGATVP 80 LEGFSLSQAA 90 DLANKGPKWE 100 KSHAEIAEQA 110 KHEAEIETRI 120 AELRKEGFWS 130 LKRLPKVPEP 140 PRPKGHWDYL 150 CEEMQWLSAD 160 FAQERRWKRG 170 VARKVVRMVI 180 RHHEEQRQKE 190 ERARREEQAK 200 LRRIASTMAK 210 DVRQFWSNVE 220 KVVQFKQQSR 230 LEEKRKKALD 240 LHLDFIVGQT 250 EKYSDLLSQS 260 LNQPLTSSKA 270 GSSPCLGSSS 280 AASSPPPPAS 290 RLDDEDGDFQ 300 PQEDEEEDDE 310 ETIEVEEQQE 320 GNDAEAQRRE 330 IELLRREGEL 340 PLEELLRSLP 350 PQLLEGPSSP 360 SQTPSSHDSD 370 TRDGPEEGAE 380 EEPPQVLEIK 390 PPPSAVTQRN 400 KQPWHPDEDD 410 EEFTANEEEA 420 EDEEDTIAAE 430 EQLEGEVDHA 440 MELSELAREG 450 ELSMEELLQQ 460 YAGAYAPGSG 470 SSEDEDEDEV 480 DANSSDCEPE 490 GPVEAEEPPQ 500 EDSSSQSDSV 510 EDRSEDEEDE 520 HSEEEETSGS 530 SASEESESEE 540 SEDAQSQSQA 550 DEEEEDDDFG 560 VEYLLARDEE 570 QSEADAGSGP 580 PTPGPTTLGP 590 KKEITDIAAA 600 AESLQPKGYT 610 LATTQVKTPI 620 PLLLRGQLRE 630 YQHIGLDWLV 640 TMYEKKLNGI 650 LADEMGLGKT 660 IQTISLLAHL 670 ACEKGNWGPH 680 LIIVPTSVML 690 NWEMELKRWC 700 PSFKILTYYG 710 AQKERKLKRQ 720 GWTKPNAFHV 730 CITSYKLVLQ 740 DHQAFRRKNW 750 RYLILDEAQN 760 IKNFKSQRWQ 770 SLLNFNSQRR 780 LLLTGTPLQN 790 SLMELWSLMH 800 FLMPHVFQSH 810 REFKEWFSNP 820 LTGMIEGSQE 830 YNEGLVKRLH 840 KVLRPFLLRR 850 VKVDVEKQMP 860 KKYEHVIRCR 870 LSKRQRCLYD 880 DFMAQTTTKE 890 TLATGHFMSV 900 INILMQLRKV 910 CNHPNLFDPR 920 PVTSPFITPG 930 ICFSTASLVL 940 RATDVHPLQR 950 IDMGRFDLIG 960 LEGRVSRYEA 970 DTFLPRHRLS 980 RRVLLEVATA 990 PDPPPRPKPV 1000 KMKVNRMLQP 1010 VPKQEGRTVV 1020 VVNNPRAPLG 1030 PVPVRPPPGP 1040 ELSAQPTPGP 1050 VPQVLPASLM 1060 VSASPAGPPL 1070 IPASRPPGPV 1080 LLPPLQPNSG 1090 SLPQVLPSPL 1100 GVLSGTSRPP 1110 TPTLSLKPTP 1120 PAPVRLSPAP 1130 PPGSSSLLKP 1140 LTVPPGYTFP 1150 PAAATTTSTT 1160 TATATTTAVP 1170 APTPAPQRLI 1180 LSPDMQARLP 1190 SGEVVSIGQL 1200 ASLAQRPVAN 1210 AGGSKPLTFQ 1220 IQGNKLTLTG 1230 AQVRQLAVGQ 1240 PRPLQRNVVH 1250 LVSAGGQHHL 1260 ISQPAHVALI 1270 QAVAPTPGPT 1280 PVSVLPSSTP 1290 STTPAPTGLS 1300 LPLAANQVPP 1310 TMVNNTGVVK 1320 IVVRQAPRDG 1330 LTPVPPLAPA 1340 PRPPSSGLPA 1350 VLNPRPTLTP 1360 GRLPTPTLGT 1370 ARAPMPTPTL 1380 VRPLLKLVHS 1390 PSPEVSASAP 1400 GAAPLTISSP 1410 LHVPSSLPGP 1420 ASSPMPIPNS 1430 SPLASPVSST 1440 VSVPLSSSLP 1450 ISVPTTLPAP 1460 ASAPLTIPIS 1470 APLTVSASGP 1480 ALLTSVTPPL 1490 APVVPAAPGP 1500 PSLAPSGASP 1510 SASALTLGLA 1520 TAPSLSSSQT 1530 PGHPLLLAPT 1540 SSHVPGLNST 1550 VAPACSPVLV 1560 PASALASPFP 1570 SAPNPAPAQA 1580 SLLAPASSAS 1590 QALATPLAPM 1600 AAPQTAILAP 1610 SPAPPLAPLP 1620 VLAPSPGAAP 1630 VLASSQTPVP 1640 VMAPSSTPGT 1650 SLASASPVPA 1660 PTPVLAPSST 1670 QTMLPAPVPS 1680 PLPSPASTQT 1690 LALAPALAPT 1700 LGGSSPSQTL 1710 SLGTGNPQGP 1720 FPTQTLSLTP 1730 ASSLVPTPAQ 1740 TLSLAPGPPL 1750 GPTQTLSLAP 1760 APPLAPASPV 1770 GPAPAHTLTL 1780 APASSSASLL 1790 APASVQTLTL 1800 SPAPVPTLGP 1810 AAAQTLALAP 1820 ASTQSPASQA 1830 SSLVVSASGA 1840 APLPVTMVSR 1850 LPVSKDEPDT 1860 LTLRSGPPSP 1870 PSTATSFGGP 1880 RPRRQPPPPP 1890 RSPFYLDSLE 1900 EKRKRQRSER 1910 LERIFQLSEA 1920 HGALAPVYGT 1930 EVLDFCTLPQ 1940 PVASPIGPRS 1950 PGPSHPTFWT 1960 YTEAAHRAVL 1970 FPQQRLDQLS 1980 EIIERFIFVM 1990 PPVEAPPPSL 2000 HACHPPPWLA 2010 PRQAAFQEQL 2020 ASELWPRARP 2030 LHRIVCNMRT 2040 QFPDLRLIQY 2050 DCGKLQTLAV 2060 LLRQLKAEGH 2070 RVLIFTQMTR 2080 MLDVLEQFLT 2090 YHGHLYLRLD 2100 GSTRVEQRQA 2110 LMERFNADKR 2120 IFCFILSTRS 2130 GGVGVNLTGA 2140 DTVVFYDSDW 2150 NPTMDAQAQD 2160 RCHRIGQTRD 2170 VHIYRLISER 2180 TVEENILKKA 2190 NQKRMLGDMA 2200 IEGGNFTTAY 2210 FKQQTIRELF 2220 DMPLEEPSSS 2230 SVPSAPEEEE 2240 ETVASKQTHI 2250 LEQALCRAED 2260 EEDIRAATQA 2270 KAEQVAELAE 2280 FNENDGFPAG 2290 EGEEAGRPGA 2300 EDEEMSRAEQ 2310 EIAALVEQLT 2320 PIERYAMKFL 2330 EASLEEVSRE 2340 ELKQAEEQVE 2350 AARKDLDQAK 2360 EEVFRLPQEE 2370 EEGPGAGDES 2380 SCGTGGGTHR 2390 RSKKAKAPER 2400 PGTRVSERLR 2410 GARAETQGAN 2420 HTPVISAHQT 2430 RSTTTPPRCS 2440 PARERVPRPA 2450 PRPRPTPASA 2460 PAAIPALVPV 2470 PVSAPVPISA 2480 PNPITILPVH 2490 ILPSPPPPSQ 2500 IPPCSSPACT 2510 PPPACTPPPA 2520 HTPPPAQTCL 2530 VTPSSPLLLG 2540 PPSVPISASV 2550 TNLPLGLRPE 2560 AELCAQALAS 2570 PESLELASVA 2580 SSETSSLSLV 2590 PPKDLLPVAV 2600 EILPVSEKNL 2610 SLTPSAPSLT 2620 LEAGSIPNGQ 2630 EQEAPDSAEG 2640 TTLTVLPEGE 2650 ELPLCVSESN 2660 GLELPPSAAS 2670 DEPLQEPLEA 2680 DRTSEELTEA 2690 KTPTSSPEKP 2700 QELVTAEVAA 2710 PSTSSSATSS 2720 PEGPSPARPP 2730 RRRTSADVEI 2740 RGQGTGRPGQ 2750 PPGPKVLRKL 2760 PGRLVTVVEE 2770 KELVRRRRQQ 2780 RGAASTLVPG 2790 VSETSASPGS 2800 PSVRSMSGPE 2810 SSPPIGGPCE 2820 AAPSSSLPTP 2830 PQQPFIARRH 2840 IELGVTGGGS 2850 PENGDGALLA 2860 ITPPAVKRRR 2870 GRPPKKNRSP 2880 ADAGRGVDEA 2890 PSSTLKGKTN 2900 GADPVPGPET 2910 LIVADPVLEP 2920 QLIPGPQPLG 2930 PQPVHRPNPL 2940 LSPVEKRRRG 2950 RPPKARDLPI 2960 PGTISSAGDG 2970 NSESRTQPPP 2980 HPSPLTPLPP 2990 LLVCPTATVA 3000 NTVTTVTIST 3010 SPPKRKRGRP 3020 PKNPPSPRPS 3030 QLPVLDRDST 3040 SVLESCGLGR 3050 RRQPQGQGES 3060 EGSSSDEDGS 3070 RPLTRLARLR 3080 LEAEGMRGRK 3090 SGGSMVVAVI 3100 QDDLDLADSG 3110 PGGLELTPPV 3120 VSLTPKLRST 3130 RLRPGSLVPP 3140 LETEKLPRKR 3150 AGAPVGGSPG 3160 LAKRGRLQPP 3170 SPLGPEGSVE 3180 ESEAEASGEE 3190 EEGDGTPRRR 3200 PGPRRLVGTT 3210 NQGDQRILRS 3220 SAPPSLAGPA 3230 VSHRGRKAKT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016604 nuclear body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0000812 Swr1 complex
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0140658 ATP-dependent chromatin remodeler activity
Molecular Function GO:0140096 catalytic activity, acting on a protein
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0042393 histone binding
Molecular Function GO:0003713 transcription coactivator activity
Biological Process GO:0141156 cAMP/PKA signal transduction
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006355 regulation of DNA-templated transcription

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.