Search Results
Overview
| Uniprot ID | Q6ZSM3 |
|---|---|
| Protein Name | Monocarboxylate transporter 12 |
| Gene Name | SLC16A12 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 476 | TQLQFIAKESDPKLQ |
Function
Functions as a transporter for creatine and as well for its precursor guanidinoacetate. Transport of creatine and GAA is independent of resting membrane potential and extracellular Na(+), Cl(-), or pH. Contributes to the process of creatine biosynthesis and distribution
Protein Sequence
10
MPSGSHWTAN
20
SSKIITWLLE
30
QPGKEEKRKT
40
MAKVNRARST
50
SPPDGGWGWM
60
IVAGCFLVTI
70
CTRAVTRCIS
80
IFFVEFQTYF
90
TQDYAQTAWI
100
HSIVDCVTML
110
CAPLGSVVSN
120
HLSCQVGIML
130
GGLLASTGLI
140
LSSFATSLKH
150
LYLTLGVLTG
160
LGFALCYSPA
170
IAMVGKYFSR
180
RKALAYGIAM
190
SGSGIGTFIL
200
APVVQLLIEQ
210
FSWRGALLIL
220
GGFVLNLCVC
230
GALMRPITLK
240
EDHTTPEQNH
250
VCRTQKEDIK
260
RVSPYSSLTK
270
EWAQTCLCCC
280
LQQEYSFLLM
290
SDFVVLAVSV
300
LFMAYGCSPL
310
FVYLVPYALS
320
VGVSHQQAAF
330
LMSILGVIDI
340
IGNITFGWLT
350
DRRCLKNYQY
360
VCYLFAVGMD
370
GLCYLCLPML
380
QSLPLLVPFS
390
CTFGYFDGAY
400
VTLIPVVTTE
410
IVGTTSLSSA
420
LGVVYFLHAV
430
PYLVSPPIAG
440
RLVDTTGSYT
450
AAFLLCGFSM
460
IFSSVLLGFA
470
RLIKRMRKTQ
480
LQFIAKESDP
490
KLQLWTNGSV
500
AYSVARELDQ
510
KHGEPVATAV
PGYSLT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0005308 | creatine transmembrane transporter activity |
| Molecular Function | GO:0022857 | transmembrane transporter activity |
| Molecular Function | GO:0015292 | uniporter activity |
| Biological Process | GO:0015881 | creatine transmembrane transport |
| Biological Process | GO:0046449 | creatinine metabolic process |
| Biological Process | GO:0150104 | transport across blood-brain barrier |
Reference
PMID: N/A