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Overview

Uniprot IDQ6ZSZ5
Protein NameRho guanine nucleotide exchange factor 18
Gene NameARHGEF18
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1238 VQQQIPTKLAASTKG

Function

Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G protein-coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950)

Protein Sequence

10 MGDDQEDDFP 20 RRLSESMEDL 30 SLDLGALQGS 40 EYLQDLGLGA 50 PSHSQPGETP 60 DSRPTGEEPG 70 RDSLFSSLAG 80 SQDLSRRRSW 90 ERSRSCSESW 100 RRLSLDASAV 110 DEEPCLPRTL 120 ASLALNLPGG 130 GLKTWTQGCL 140 SGGGTPAESP 150 GKECDSPKKR 160 GRSRSVPVSF 170 YEIRSPEISP 180 GLEVPTPPVQ 190 GLEPPVLECM 200 EKDHVEPDHV 210 LIVQQVLQEL 220 RQYHGARQRA 230 CMSASPGGAH 240 SNLTWFEFLS 250 ESEDGAGKNE 260 KSDKSTSVKR 270 RLSCLRSRVT 280 RQKEKGKSPA 290 HLKDKGQDAR 300 ERRECVNGHQ 310 LLQGTFSGPS 320 SCPLCGKPFL 330 SSASLKEHPR 340 GTLLSDGSPA 350 LSRNVGMTVS 360 QKGGPQPTPS 370 PAGPGTQLGP 380 ITGEMDEADS 390 AFLKFKQTAD 400 DSLSLTSPNT 410 ESIFVEDPYT 420 ASLRSEIESD 430 GHEFEAESWS 440 LAVDAAYAKK 450 QKREVVKRQD 460 VLYELMQTEV 470 HHVRTLKIML 480 KVYSRALQEE 490 LQFSSKAIGR 500 LFPCADDLLE 510 THSHFLARLK 520 ERRQESLEEG 530 SDRNYVIQKI 540 GDLLVQQFSG 550 ENGERMKEKY 560 GVFCSGHNEA 570 VSHYKLLLQQ 580 NKKFQNLIKK 590 IGNFSIVRRL 600 GVQECILLVT 610 QRITKYPVLV 620 ERIIQNTEAG 630 TEDYEDLTQA 640 LNLIKDIISQ 650 VDAKVSECEK 660 GQRLREIAGK 670 MDLKSSSKLK 680 NGLTFRKEDM 690 LQRQLHLEGM 700 LCWKTTSGRL 710 KDILAILLTD 720 VLLLLQEKDQ 730 KYVFASVDSK 740 PPVISLQKLI 750 VREVANEEKA 760 MFLISASLQG 770 PEMYEIYTSS 780 KEDRNAWMAH 790 IQRAVESCPD 800 EEEGPFSLPE 810 EERKVVEARA 820 TRLRDFQERL 830 SMKDQLIAQS 840 LLEKQQIYLE 850 MAEMGGLEDL 860 PQPRGLFRGG 870 DPSETLQGEL 880 ILKSAMSEIE 890 GIQSLICRQL 900 GSANGQAEDG 910 GSSTGPPRRA 920 ETFAGYDCTN 930 SPTKNGSFKK 940 KVSSTDPRPR 950 DWRGPPNSPD 960 LKLSDSDIPG 970 SSEESPQVVE 980 APGTESDPRL 990 PTVLESELVQ 1000 RIQTLSQLLL 1010 NLQAVIAHQD 1020 SYVETQRAAI 1030 QEREKQFRLQ 1040 STRGNLLLEQ 1050 ERQRNFEKQR 1060 EERAALEKLQ 1070 SQLRHEQQRW 1080 ERERQWQHQE 1090 LERAGARLQE 1100 REGEARQLRE 1110 RLEQERAELE 1120 RQRQAYQHDL 1130 ERLREAQRAV 1140 ERERERLELL 1150 RRLKKQNTAP 1160 GALPPDTLAE 1170 AQPPSHPPSF 1180 NGEGLEGPRV 1190 SMLPSGVGPE 1200 YAERPEVARR 1210 DSAPTENRLA 1220 KSDVPIQLLS 1230 ATNQFQRQAA 1240 VQQQIPTKLA 1250 ASTKGGKDKG 1260 GKSRGSQRWE 1270 SSASFDLKQQ 1280 LLLNKLMGKD 1290 ESTSRNRRSL 1300 SPILPGRHSP 1310 APPPDPGFPA 1320 PSPPPADSPS 1330 EGFSLKAGGT 1340 ALLPGPPAPS 1350 PLPATPLSAK 1360 EDASKEDVIF F

Gene Ontology

Classification GO ID Description
Cellular Component GO:0045177 apical part of cell
Cellular Component GO:0016324 apical plasma membrane
Cellular Component GO:0030054 cell junction
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0051497 negative regulation of stress fiber assembly
Biological Process GO:0150105 protein localization to cell-cell junction
Biological Process GO:0008360 regulation of cell shape
Biological Process GO:0035023 regulation of Rho protein signal transduction
Biological Process GO:0007264 small GTPase-mediated signal transduction

Reference

PMID: N/A