Search Results

Overview

Uniprot ID	Q6ZT12
Protein Name	E3 ubiquitin-protein ligase UBR3
Gene Name	UBR3
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
277	LTNQQNYKDLTSGLG

Function

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Does not bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). May play a role in Shh signaling by mediating the ubiquitination of Kif7 (By similarity). May be important for MYH9 function in certain tissues, possibly by regulating the ubiquitination of MYH9 and consequently affecting its interaction with MYO7A (PubMed:27331610)

Protein Sequence

10 MAAAAAAAVG 20 GQQPSQPELP 30 APGLALDKAA 40 TAAHLKAALS 50 RPDNRAGAEE 60 LQALLERVLS 70 AERPLAAAAG 80 GEDAAAAGGG 90 GGPGAAEEEA 100 LEWCKCLLAG 110 GGGYDEFCAA 120 VRAYDPAALC 130 GLVWTANFVA 140 YRCRTCGISP 150 CMSLCAECFH 160 QGDHTGHDFN 170 MFRSQAGGAC 180 DCGDSNVMRE 190 SGFCKRHQIK 200 SSSNIPCVPK 210 DLLMMSEFVL 220 PRFIFCLIQY 230 LREGYNEPAA 240 DGPSEKDLNK 250 VLQLLEPQIS 260 FLEDLTKMGG 270 AMRSVLTQVL 280 TNQQNYKDLT 290 SGLGENACVK 300 KSHEKYLIAL 310 KSSGLTYPED 320 KLVYGVQEPS 330 AGTSSLAVQG 340 FIGATGTLGQ 350 VDSSDEDDQD 360 GSQGLGKRKR 370 VKLSSGTKDQ 380 SIMDVLKHKS 390 FLEELLFWTI 400 KYEFPQKMVT 410 FLLNMLPDQE 420 YKVAFTKTFV 430 QHYAFIMKTL 440 KKSHESDTMS 450 NRIVHISVQL 460 FSNEELARQV 470 TEECQLLDIM 480 VTVLLYMMES 490 CLIKSELQDE 500 ENSLHVVVNC 510 GEALLKNNTY 520 WPLVSDFINI 530 LSHQSVAKRF 540 LEDHGLLVTW 550 MNFVSFFQGM 560 NLNKRELNEH 570 VEFESQTYYA 580 AFAAELEACA 590 QPMWGLLSHC 600 KVRETQEYTR 610 NVVRYCLEAL 620 QDWFDAINFV 630 DEPAPNQVTF 640 HLPLHRYYAM 650 FLSKAVKCQE 660 LDLDSVLPDQ 670 EMLMKLMIHP 680 LQIQASLAEI 690 HSNMWVRNGL 700 QIKGQAMTYV 710 QSHFCNSMID 720 PDIYLLQVCA 730 SRLDPDYFIS 740 SVFERFKVVD 750 LLTMASQHQN 760 TVLDAEHERS 770 MLEGALTFLV 780 ILLSLRLHLG 790 MSDDEILRAE 800 MVAQLCMNDR 810 THSSLLDLIP 820 ENPNPKSGII 830 PGSYSFESVL 840 SAVADFKAPV 850 FEPGGSMQQG 860 MYTPKAEVWD 870 QEFDPVMVIL 880 RTVYRRDVQS 890 AMDRYTAFLK 900 QSGKFPGNPW 910 PPYKKRTSLH 920 PSYKGLMRLL 930 HCKTLHIVLF 940 TLLYKILMDH 950 QNLSEHVLCM 960 VLYLIELGLE 970 NSAEEESDEE 980 ASVGGPERCH 990 DSWFPGSNLV 1000 SNMRHFINYV 1010 RVRVPETAPE 1020 VKRDSPASTS 1030 SDNLGSLQNS 1040 GTAQVFSLVA 1050 ERRKKFQEII 1060 NRSSSEANQV 1070 VRPKTSSKWS 1080 APGSAPQLTT 1090 AILEIKESIL 1100 SLLIKLHHKL 1110 SGKQNSYYPP 1120 WLDDIEILIQ 1130 PEIPKYSHGD 1140 GITAVERILL 1150 KAASQSRMNK 1160 RIIEEICRKV 1170 TPPVPPKKVT 1180 AAEKKTLDKE 1190 ERRQKARERQ 1200 QKLLAEFASR 1210 QKSFMETAMD 1220 VDSPENDIPM 1230 EITTAEPQVS 1240 EAVYDCVICG 1250 QSGPSSEDRP 1260 TGLVVLLQAS 1270 SVLGQCRDNV 1280 EPKKLPISEE 1290 EQIYPWDTCA 1300 AVHDVRLSLL 1310 QRYFKDSSCL 1320 LAVSIGWEGG 1330 VYVQTCGHTL 1340 HIDCHKSYME 1350 SLRNDQVLQG 1360 FSVDKGEFTC 1370 PLCRQFANSV 1380 LPCYPGSNVE 1390 NNPWQRPSNK 1400 SIQDLIKEVE 1410 ELQGRPGAFP 1420 SETNLSKEME 1430 SVMKDIKNTT 1440 QKKYRDYSKT 1450 PGSPDNDFLF 1460 MYSVARTNLE 1470 LELIHRGGNL 1480 CSGGASTAGK 1490 RSCLNQLFHV 1500 LALHMRLYSI 1510 DSEYNPWRKL 1520 TQLEEMNPQL 1530 GYEEQQPEVP 1540 ILYHDVTSLL 1550 LIQILMMPQP 1560 LRKDHFTCIV 1570 KVLFTLLYTQ 1580 ALAALSVKCS 1590 EEDRSAWKHA 1600 GALKKSTCDA 1610 EKSYEVLLSF 1620 VISELFKGKL 1630 YHEEGTQECA 1640 MVNPIAWSPE 1650 SMEKCLQDFC 1660 LPFLRITSLL 1670 QHHLFGEDLP 1680 SCQEEEEFSV 1690 LASCLGLLPT 1700 FYQTEHPFIS 1710 ASCLDWPVPA 1720 FDIITQWCFE 1730 IKSFTERHAE 1740 QGKALLIQES 1750 KWKLPHLLQL 1760 PENYNTIFQY 1770 YHRKTCSVCT 1780 KVPKDPAVCL 1790 VCGTFVCLKG 1800 LCCKQQSYCE 1810 CVLHSQNCGA 1820 GTGIFLLINA 1830 SVIIIIRGHR 1840 FCLWGSVYLD 1850 AHGEEDRDLR 1860 RGKPLYICKE 1870 RYKVLEQQWI 1880 SHTFDHINKR WGPHYNGL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0000151	ubiquitin ligase complex
Molecular Function	GO:0061630	ubiquitin protein ligase activity
Molecular Function	GO:0004842	ubiquitin-protein transferase activity
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0009792	embryo development ending in birth or egg hatching
Biological Process	GO:1904878	negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
Biological Process	GO:0045732	positive regulation of protein catabolic process
Biological Process	GO:0016567	protein ubiquitination
Biological Process	GO:0007608	sensory perception of smell
Biological Process	GO:0001967	suckling behavior
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process
Biological Process	GO:0071596	ubiquitin-dependent protein catabolic process via the N-end rule pathway

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.