Search Results

Overview

Uniprot IDQ6ZU64
Protein NameCilia- and flagella-associated protein 65
Gene NameCFAP65
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1069 ICLTACPKQRSQYSW

Function

Plays a role in flagellar formation and sperm motility (PubMed:33472045). Essential for acrosome formation, manchette organization, spermatid head morphogenesis and mitochondrial sheath assembly within the sperm flagellum during spermiogenesis (By similarity). Also required for proper assembly and stabilization of the C2a projection, a structural subunit of the central pair apparatus within the axoneme of motile cilia and flagella (By similarity)

Protein Sequence

10 MFTLTGCRLV 20 EKTQKVENPS 30 VSFASSFPLI 40 PLLLRGKSVQ 50 KKQAESKSQI 60 KLHTQSAPFG 70 LCPKDMMLTQ 80 APSSVVRSRN 90 SRNHTVNSGG 100 SCLSASTVAI 110 PAINDSSAAM 120 SACSTISAQP 130 ASSMDTQMHS 140 PKKQERVNKR 150 VIWGIEVAEE 160 LHWKGWELGK 170 ETTRNLVLKN 180 RSLKLQKMKY 190 RPPKTKFFFT 200 VIPQPIFLSP 210 GITLTLPIVF 220 RPLEAKEYMD 230 QLWFEKAEGM 240 FCVGLRATLP 250 CHRLICRPPS 260 LQLPMCAVGD 270 TTEAFFCLDN 280 VGDLPTFFTW 290 EFSSPFQMLP 300 ATGLLEPGQA 310 SQIKVTFQPL 320 TAVIYEVQAT 330 CWYGAGSRQR 340 SSIQLQAVAK 350 CAQLLVSIKH 360 KCPEDQDAEG 370 FQKLLYFGSV 380 AVGCTSERQI 390 RLHNPSAVNA 400 PFRIEISPDE 410 LAEDQAFSCP 420 TAHGIVLPGE 430 KKCVSVFFHP 440 KTLDTRTVDY 450 CSIMPSGCAS 460 KTLLKVVGFC 470 RGPAVSLQHY 480 CVNFSWVNLG 490 ERSEQPLWIE 500 NQSDCTAHFQ 510 FAIDCLESVF 520 TIRPAFGTLV 530 GKARMTLHCA 540 FQPTHPIICF 550 RRVACLIHHQ 560 DPLFLDLMGT 570 CHSDSTKPAI 580 LKPQHLTWYR 590 THLARGLTLY 600 PPDILDAMLK 610 EKKLAQDQNG 620 ALMIPIQDLE 630 DMPAPQYPYI 640 PPMTEFFFDG 650 TSDITIFPPP 660 ISVEPVEVDF 670 GACPGPEAPN 680 PVPLCLMNHT 690 KGKIMVVWTR 700 RSDCPFWVTP 710 ESCDVPPLKS 720 MAMRLHFQPP 730 HPNCLYTVEL 740 EAFAIYKVLQ 750 SYSNIEEDCT 760 MCPSWCLTVR 770 ARGHSYFAGF 780 EHHIPQYSLD 790 VPKLFPAVSS 800 GEPTYRSLLL 810 VNKDCKLLTF 820 SLAPQRGSDV 830 ILRPTSGLVA 840 PGAHQIILIC 850 TYPEGSSWKQ 860 HTFYLQCNAS 870 PQYLKEVSMY 880 SREEPLQLKL 890 DTHKSLYFKP 900 TWVGCSSTSP 910 FTFRNPSRLP 920 LQFEWRVSEQ 930 HRKLLAVQPS 940 RGLIQPNERL 950 TLTWTFSPLE 960 ETKYLFQVGM 970 WVWEAGLSPN 980 ANPAATTHYM 990 LRLVGVGLTS 1000 SLSAKEKELA 1010 FGNVLVNSKQ 1020 SRFLVLLNDG 1030 NCTLYYRLYL 1040 EQGSPEAVDN 1050 HPLALQLDRT 1060 EGSMPPRSQD 1070 TICLTACPKQ 1080 RSQYSWTITY 1090 SLLSHRDNKA 1100 GEKQELCCVS 1110 LVAVYPLLSI 1120 LDVSSMGSAE 1130 GITRKHLWRL 1140 FSLDLLNSYL 1150 ERDPTPCELT 1160 YKVPTRHSMS 1170 QIPPVLTPLR 1180 LDFNFGAAPF 1190 KAPPSVVFLA 1200 LKNSGVVSLD 1210 WAFLLPSDQR 1220 IDVELWAEQA 1230 ELNSTELHQM 1240 RVQDNCLFSI 1250 SPKAGSLSPG 1260 QEQMVELKYS 1270 HLFIGTDHLP 1280 VLFKVSHGRE 1290 ILLNFIGVTV 1300 KPEQKYVHFT 1310 STTHQFIPIP 1320 IGDTLPPRQI 1330 YELYNGGSVP 1340 VTYEVQTDVL 1350 SQVQEKNFDH 1360 PIFCCLNPKG 1370 EIQPGSTARV 1380 LWIFSPIEAK 1390 TYTVDVPIHI 1400 LGWNSALIHF 1410 QGVGYNPHMM 1420 GDTAPFHNIS 1430 SWDNSSIHSR 1440 LVVPGQNVFL 1450 SQSHISLGNI 1460 PVQSKCSRLL 1470 FLNNISKNEE 1480 IAFSWQPSPL 1490 DFGEVSVSPM 1500 IGVVAPEETV 1510 PFVVTLRASV 1520 HASFYSADLV 1530 CKLYSQQLMR 1540 QYHKELQEWK 1550 DEKVRQEVEF 1560 TITDMKVKKR 1570 TCCTACEPAR 1580 KYKTLPPIKN 1590 QQSVSRPASW 1600 KLQTPKEEVS 1610 WPCPQPPSPG 1620 MLCLGLTARA 1630 HATDYFLANF 1640 FSEFPCHFLH 1650 RELPKRKAPR 1660 EESETSEEKS 1670 PNKWGPVSKQ 1680 KKQLLVDILT 1690 TIIRGLLEDK 1700 NFHEAVDQSL 1710 VEQVPYFRQF 1720 WNEQSTKFMD 1730 QKNSLYLMPI 1740 LPVPSSSWED 1750 GKGKQPKEDR 1760 PEHYPGLGKK 1770 EEGEEEKGEE 1780 EEEELEEEEE 1790 EEEETEEEEL 1800 GKEEIEEKEE 1810 ERDEKEEKVS 1820 WAGIGPTPQP 1830 ESQESMQWQW 1840 QQQLNVMVKE 1850 EQEQDEKEAI 1860 RRLPAFANLQ 1870 EALLENMIQN 1880 ILVEASRGEV 1890 VLTSRPRVIA 1900 LPPFCVPRSL 1910 TPDTLLPTQQ 1920 AEVLHPVVPL PTDLP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0002080 acrosomal membrane
Cellular Component GO:0001669 acrosomal vesicle
Cellular Component GO:1990716 axonemal central apparatus
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0036126 sperm flagellum
Cellular Component GO:0097225 sperm midpiece
Molecular Function GO:0003723 RNA binding
Biological Process GO:0001675 acrosome assembly
Biological Process GO:0003341 cilium movement
Biological Process GO:0030317 flagellated sperm motility
Biological Process GO:0007288 sperm axoneme assembly
Biological Process GO:0120317 sperm mitochondrial sheath assembly
Biological Process GO:0007283 spermatogenesis

Reference

[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.