Search Results

Overview

Uniprot ID	Q6ZUJ8
Protein Name	Phosphoinositide 3-kinase adapter protein 1
Gene Name	PIK3AP1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
481	DGFSRATKDSMIRKF
669	REKQKSGKQTDLEIT
688	HSQHLPAKVEFGVYE

Function

Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL

Protein Sequence

10 MAASGVPRGC 20 DILIVYSPDA 30 EEWCQYLQTL 40 FLSSRQVRSQ 50 KILTHRLGPE 60 ASFSAEDLSL 70 FLSTRCVVVL 80 LSAELVQHFH 90 KPALLPLLQR 100 AFHPPHRVVR 110 LLCGVRDSEE 120 FLDFFPDWAH 130 WQELTCDDEP 140 ETYVAAVKKA 150 ISEDSGCDSV 160 TDTEPEDEKV 170 VSYSKQQNLP 180 TVTSPGNLMV 190 VQPDRIRCGA 200 ETTVYVIVRC 210 KLDDRVATEA 220 EFSPEDSPSV 230 RMEAKVENEY 240 TISVKAPNLS 250 SGNVSLKIYS 260 GDLVVCETVI 270 SYYTDMEEIG 280 NLLSNAANPV 290 EFMCQAFKIV 300 PYNTETLDKL 310 LTESLKNNIP 320 ASGLHLFGIN 330 QLEEEDMMTN 340 QRDEELPTLL 350 HFAAKYGLKN 360 LTALLLTCPG 370 ALQAYSVANK 380 HGHYPNTIAE 390 KHGFRDLRQF 400 IDEYVETVDM 410 LKSHIKEELM 420 HGEEADAVYE 430 SMAHLSTDLL 440 MKCSLNPGCD 450 EDLYESMAAF 460 VPAATEDLYV 470 EMLQASTSNP 480 IPGDGFSRAT 490 KDSMIRKFLE 500 GNSMGMTNLE 510 RDQCHLGQEE 520 DVYHTVDDDE 530 AFSVDLASRP 540 PVPVPRPETT 550 APGAHQLPDN 560 EPYIFKVFAE 570 KSQERPGNFY 580 VSSESIRKGP 590 PVRPWRDRPQ 600 SSIYDPFAGM 610 KTPGQRQLIT 620 LQEQVKLGIV 630 NVDEAVLHFK 640 EWQLNQKKRS 650 ESFRFQQENL 660 KRLRDSITRR 670 QREKQKSGKQ 680 TDLEITVPIR 690 HSQHLPAKVE 700 FGVYESGPRK 710 SVIPPRTELR 720 RGDWKTDSTS 730 STASSTSNRS 740 STRSLLSVSS 750 GMEGDNEDNE 760 VPEVTRSRSP 770 GPPQVDGTPT 780 MSLERPPRVP 790 PRAASQRPPT 800 RETFHPPPPV PPRGR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding
Molecular Function	GO:0005102	signaling receptor binding
Biological Process	GO:0051897	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Process	GO:0050727	regulation of inflammatory response
Biological Process	GO:0034134	toll-like receptor 2 signaling pathway
Biological Process	GO:0034142	toll-like receptor 4 signaling pathway
Biological Process	GO:0034154	toll-like receptor 7 signaling pathway
Biological Process	GO:0034162	toll-like receptor 9 signaling pathway

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.