Search Results
Overview
| Uniprot ID | Q6ZVM7 |
|---|---|
| Protein Name | TOM1-like protein 2 |
| Gene Name | TOM1L2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 106 | LVKIISPKNNPPTIV |
Function
Acts as a MYO6/Myosin VI adapter protein that targets myosin VI to endocytic structures (PubMed:23023224). May also play a role in recruiting clathrin to endosomes (PubMed:16412388). May regulate growth factor-induced mitogenic signaling (PubMed:16479011)
Protein Sequence
10
MEFLLGNPFS
20
TPVGQCLEKA
30
TDGSLQSEDW
40
TLNMEICDII
50
NETEEGPKDA
60
IRALKKRLNG
70
NRNYREVMLA
80
LTVLETCVKN
90
CGHRFHILVA
100
NRDFIDSVLV
110
KIISPKNNPP
120
TIVQDKVLAL
130
IQAWADAFRS
140
SPDLTGVVHI
150
YEELKRKGVE
160
FPMADLDALS
170
PIHTPQRSVP
180
EVDPAATMPR
190
SQSQQRTSAG
200
SYSSPPPAPY
210
SAPQAPALSV
220
TGPITANSEQ
230
IARLRSELDV
240
VRGNTKVMSE
250
MLTEMVPGQE
260
DSSDLELLQE
270
LNRTCRAMQQ
280
RIVELISRVS
290
NEEVTEELLH
300
VNDDLNNVFL
310
RYERFERYRS
320
GRSVQNASNG
330
VLNEVTEDNL
340
IDLGPGSPAV
350
VSPMVGNTAP
360
PSSLSSQLAG
370
LDLGTESVSG
380
TLSSLQQCNP
390
RDGFDMFAQT
400
RGNSLAEQRK
410
TVTYEDPQAV
420
GGLASALDNR
430
KQSSEGIPVA
440
QPSVMDDIEV
450
WLRTDLKGDD
460
LEEGVTSEEF
470
DKFLEERAKA
480
AEMVPDLPSP
490
PMEAPAPASN
500
PSGRKKPERS
EDALFAL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0016020 | membrane |
| Molecular Function | GO:0030276 | clathrin binding |
| Molecular Function | GO:0035091 | phosphatidylinositol binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0043130 | ubiquitin binding |
| Biological Process | GO:0045839 | negative regulation of mitotic nuclear division |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0007165 | signal transduction |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.