Search Results

Overview

Uniprot IDQ709C8
Protein NameIntermembrane lipid transfer protein VPS13C
Gene NameVPS13C
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
3487 RITGSVGKGLAAITM
3557 GFFKGIGKGLVGAVA

Function

Mediates the transfer of lipids between membranes at organelle contact sites (By similarity). Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential (PubMed:26942284). Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization (PubMed:26942284)

Protein Sequence

10 MVLESVVADL 20 LNRFLGDYVE 30 NLNKSQLKLG 40 IWGGNVALDN 50 LQIKENALSE 60 LDVPFKVKAG 70 QIDKLTLKIP 80 WKNLYGEAVV 90 ATLEGLYLLV 100 VPGASIKYDA 110 VKEEKSLQDV 120 KQKELSRIEE 130 ALQKAAEKGT 140 HSGEFIYGLE 150 NFVYKDIKPG 160 RKRKKHKKHF 170 KKPFKGLDRS 180 KDKPKEAKKD 190 TFVEKLATQV 200 IKNVQVKITD 210 IHIKYEDDVT 220 DPKRPLSFGV 230 TLGELSLLTA 240 NEHWTPCILN 250 EADKIIYKLI 260 RLDSLSAYWN 270 VNCSMSYQRS 280 REQILDQLKN 290 EILTSGNIPP 300 NYQYIFQPIS 310 ASAKLYMNPY 320 AESELKTPKL 330 DCNIEIQNIA 340 IELTKPQYLS 350 MIDLLESVDY 360 MVRNAPYRKY 370 KPYLPLHTNG 380 RRWWKYAIDS 390 VLEVHIRRYT 400 QMWSWSNIKK 410 HRQLLKSYKI 420 AYKNKLTQSK 430 VSEEIQKEIQ 440 DLEKTLDVFN 450 IILARQQAQV 460 EVIRSGQKLR 470 KKSADTGEKR 480 GGWFSGLWGK 490 KESKKKDEES 500 LIPETIDDLM 510 TPEEKDKLFT 520 AIGYSESTHN 530 LTLPKQYVAH 540 IMTLKLVSTS 550 VTIRENKNIP 560 EILKIQIIGL 570 GTQVSQRPGA 580 QALKVEAKLE 590 HWYITGLRQQ 600 DIVPSLVASI 610 GDTTSSLLKI 620 KFETNPEDSP 630 ADQTLIVQSQ 640 PVEVIYDAKT 650 VNAVVEFFQS 660 NKGLDLEQIT 670 SATLMKLEEI 680 KERTATGLTH 690 IIETRKVLDL 700 RINLKPSYLV 710 VPQTGFHHEK 720 SDLLILDFGT 730 FQLNSKDQGL 740 QKTTNSSLEE 750 IMDKAYDKFD 760 VEIKNVQLLF 770 ARAEETWKKC 780 RFQHPSTMHI 790 LQPMDIHVEL 800 AKAMVEKDIR 810 MARFKVSGGL 820 PLMHVRISDQ 830 KMKDVLYLMN 840 SIPLPQKSSA 850 QSPERQVSSI 860 PIISGGTKGL 870 LGTSLLLDTV 880 ESESDDEYFD 890 AEDGEPQTCK 900 SMKGSELKKA 910 AEVPNEELIN 920 LLLKFEIKEV 930 ILEFTKQQKE 940 EDTILVFNVT 950 QLGTEATMRT 960 FDLTVVSYLK 970 KISLDYHEIE 980 GSKRKPLHLI 990 SSSDKPGLDL 1000 LKVEYIKADK 1010 NGPSFQTAFG 1020 KTEQTVKVAF 1030 SSLNLLLQTQ 1040 ALVASINYLT 1050 TIIPSDDQSI 1060 SVAKEVQIST 1070 EKQQKNSTLP 1080 KAIVSSRDSD 1090 IIDFRLFAKL 1100 NAFCVIVCNE 1110 KNNIAEIKIQ 1120 GLDSSLSLQS 1130 RKQSLFARLE 1140 NIIVTDVDPK 1150 TVHKKAVSIM 1160 GNEVFRFNLD 1170 LYPDATEGDL 1180 YTDMSKVDGV 1190 LSLNVGCIQI 1200 VYLHKFLMSL 1210 LNFLNNFQTA 1220 KESLSAATAQ 1230 AAERAATSVK 1240 DLAQRSFRVS 1250 INIDLKAPVI 1260 VIPQSSISTN 1270 AVVVDLGLIR 1280 VHNQFSLVSD 1290 EDYLNPPVID 1300 RMDVQLTKLT 1310 LYRTVIQPGI 1320 YHPDIQLLHP 1330 INLEFLVNRN 1340 LAASWYHKVP 1350 VVEIKGHLDS 1360 MNVSLNQEDL 1370 NLLFRILTEN 1380 LCEGTEDLDK 1390 VKPRVQETGE 1400 IKEPLEISIS 1410 QDVHDSKNTL 1420 TTGVEEIRSV 1430 DIINMLLNFE 1440 IKEVVVTLMK 1450 KSEKKGRPLH 1460 ELNVLQLGME 1470 AKVKTYDMTA 1480 KAYLKKISMQ 1490 CFDFTDSKGE 1500 PLHIINSSNV 1510 TDEPLLKMLL 1520 TKADSDGPEF 1530 KTIHDSTKQR 1540 LKVSFASLDL 1550 VLHLEALLSF 1560 MDFLSSAAPF 1570 SEPSSSEKES 1580 ELKPLVGESR 1590 SIAVKAVSSN 1600 ISQKDVFDLK 1610 ITAELNAFNV 1620 FVCDQKCNIA 1630 DIKIHGMDAS 1640 ISVKPKQTDV 1650 FARLKDIIVM 1660 NVDLQSIHKK 1670 AVSILGDEVF 1680 RFQLTLYPDA 1690 TEGEAYADMS 1700 KVDGKLSFKV 1710 GCIQIVYVHK 1720 FFMSLLNFLN 1730 NFQTAKEALS 1740 TATVQAAERA 1750 ASSMKDLAQK 1760 SFRLLMDINL 1770 KAPVIIIPQS 1780 SVSPNAVIAD 1790 LGLIRVENKF 1800 SLVPMEHYSL 1810 PPVIDKMNIE 1820 LTQLKLSRTI 1830 LQASLPQNDI 1840 EILKPVNMLL 1850 SIQRNLAAAW 1860 YVQIPGMEIK 1870 GKLKPMQVAL 1880 SEDDLTVLMK 1890 ILLENLGEAS 1900 SQPSPTQSVQ 1910 ETVRVRKVDV 1920 SSVPDHLKEQ 1930 EDWTDSKLSM 1940 NQIVSLQFDF 1950 HFESLSIILY 1960 NNDINQESGV 1970 AFHNDSFQLG 1980 ELRLHLMASS 1990 GKMFKDGSMN 2000 VSVKLKTCTL 2010 DDLREGIERA 2020 TSRMIDRKND 2030 QDNNSSMIDI 2040 SYKQDKNGSQ 2050 IDAVLDKLYV 2060 CASVEFLMTV 2070 ADFFIKAVPQ 2080 SPENVAKETQ 2090 ILPRQTATGK 2100 VKIEKDDSVR 2110 PNMTLKAMIT 2120 DPEVVFVASL 2130 TKADAPALTA 2140 SFQCNLSLST 2150 SKLEQMMEAS 2160 VRDLKVLACP 2170 FLREKRGKNI 2180 TTVLQPCSLF 2190 MEKCTWASGK 2200 QNINIMVKEF 2210 IIKISPIILN 2220 TVLTIMAALS 2230 PKTKEDGSKD 2240 TSKEMENLWG 2250 IKSINDYNTW 2260 FLGVDTATEI 2270 TESFKGIEHS 2280 LIEENCGVVV 2290 ESIQVTLECG 2300 LGHRTVPLLL 2310 AESKFSGNIK 2320 NWTSLMAAVA 2330 DVTLQVHYYN 2340 EIHAVWEPLI 2350 ERVEGKRQWN 2360 LRLDVKKNPV 2370 QDKSLLPGDD 2380 FIPEPQMAIH 2390 ISSGNTMNIT 2400 ISKSCLNVFN 2410 NLAKGFSEGT 2420 ASTFDYSLKD 2430 RAPFTVKNAV 2440 GVPIKVKPNC 2450 NLRVMGFPEK 2460 SDIFDVDAGQ 2470 NLELEYASMV 2480 PSSQGNLSIL 2490 SRQESSFFTL 2500 TIVPHGYTEV 2510 ANIPVARPGR 2520 RLYNVRNPNA 2530 SHSDSVLVQI 2540 DATEGNKVIT 2550 LRSPLQIKNH 2560 FSIAFIIYKF 2570 VKNVKLLERI 2580 GIARPEEEFH 2590 VPLDSYRCQL 2600 FIQPAGILEH 2610 QYKESTTYIS 2620 WKEELHRSRE 2630 VRCMLQCPSV 2640 EVSFLPLIVN 2650 TVALPDELSY 2660 ICTHGEDWDV 2670 AYIIHLYPSL 2680 TLRNLLPYSL 2690 RYLLEGTAET 2700 HELAEGSTAD 2710 VLHSRISGEI 2720 MELVLVKYQG 2730 KNWNGHFRIR 2740 DTLPEFFPVC 2750 FSSDSTEVTT 2760 VDLSVHVRRI 2770 GSRMVLSVFS 2780 PYWLINKTTR 2790 VLQYRSEDIH 2800 VKHPADFRDI 2810 ILFSFKKKNI 2820 FTKNKVQLKI 2830 STSAWSSSFS 2840 LDTVGSYGCV 2850 KCPANNMEYL 2860 VGVSIKMSSF 2870 NLSRIVTLTP 2880 FCTIANKSSL 2890 ELEVGEIASD 2900 GSMPTNKWNY 2910 IASSECLPFW 2920 PESLSGKLCV 2930 RVVGCEGSSK 2940 PFFYNRQDNG 2950 TLLSLEDLNG 2960 GILVDVNTAE 2970 HSTVITFSDY 2980 HEGSAPALIM 2990 NHTPWDILTY 3000 KQSGSPEEMV 3010 LLPRQARLFA 3020 WADPTGTRKL 3030 TWTYAANVGE 3040 HDLLKDGCGQ 3050 FPYDANIQIH 3060 WVSFLDGRQR 3070 VLLFTDDVAL 3080 VSKALQAEEM 3090 EQADYEITLS 3100 LHSLGLSLVN 3110 NESKQEVSYI 3120 GITSSGVVWE 3130 VKPKQKWKPF 3140 SQKQIILLEQ 3150 SYQKHQISRD 3160 HGWIKLDNNF 3170 EVNFDKDPME 3180 MRLPIRSPIK 3190 RDFLSGIQIE 3200 FKQSSHQRSL 3210 RARLYWLQVD 3220 NQLPGAMFPV 3230 VFHPVAPPKS 3240 IALDSEPKPF 3250 IDVSVITRFN 3260 EYSKVLQFKY 3270 FMVLIQEMAL 3280 KIDQGFLGAI 3290 IALFTPTTDP 3300 EAERRRTKLI 3310 QQDIDALNAE 3320 LMETSMTDMS 3330 ILSFFEHFHI 3340 SPVKLHLSLS 3350 LGSGGEESDK 3360 EKQEMFAVHS 3370 VNLLLKSIGA 3380 TLTDVDDLIF 3390 KLAYYEIRYQ 3400 FYKRDQLIWS 3410 VVRHYSEQFL 3420 KQMYVLVLGL 3430 DVLGNPFGLI 3440 RGLSEGVEAL 3450 FYEPFQGAVQ 3460 GPEEFAEGLV 3470 IGVRSLFGHT 3480 VGGAAGVVSR 3490 ITGSVGKGLA 3500 AITMDKEYQQ 3510 KRREELSRQP 3520 RDFGDSLARG 3530 GKGFLRGVVG 3540 GVTGIITKPV 3550 EGAKKEGAAG 3560 FFKGIGKGLV 3570 GAVARPTGGI 3580 VDMASSTFQG 3590 IQRAAESTEE 3600 VSSLRPPRLI 3610 HEDGIIRPYD 3620 RQESEGSDLL 3630 ENHIKKLEGE 3640 TYRYHCAIPG 3650 SKKTILMVTN 3660 RRVLCIKEVE 3670 ILGLMCVDWQ 3680 CPFEDFVFPP 3690 SVSENVLKIS 3700 VKEQGLFHKK 3710 DSANQGCVRK 3720 VYLKDTATAE 3730 RACNAIEDAQ 3740 STRQQQKLMK 3750 QSSVRLLRPQ LPS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0032127 dense core granule membrane
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005770 late endosome
Cellular Component GO:0031902 late endosome membrane
Cellular Component GO:0005811 lipid droplet
Cellular Component GO:0005765 lysosomal membrane
Cellular Component GO:0005764 lysosome
Cellular Component GO:0005741 mitochondrial outer membrane
Biological Process GO:0006895 Golgi to endosome transport
Biological Process GO:0006869 lipid transport
Biological Process GO:0007005 mitochondrion organization
Biological Process GO:1905090 negative regulation of type 2 mitophagy
Biological Process GO:0045053 protein retention in Golgi apparatus
Biological Process GO:0006623 protein targeting to vacuole

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.