Overview
| Uniprot ID | Q70CQ1 |
|---|
| Protein Name | Ubiquitin carboxyl-terminal hydrolase 49 |
|---|
| Gene Name | USP49 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 353 |
QNKEPSSKHISLCRE |
Function
Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub), a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing (PubMed:23824326). Antagonizes DNA double-strand break-induced ubiquitination of H2AX thereby participating in the maintenance of genome integrity (PubMed:35598681). Plays a role in the negative regulation of cell proliferation through the AKT pathway by deubiquitinating FKBP51, leading to enhanced AKT1 dephosphorylation by PHLPP1 (PubMed:28363942). Also regulates the mitotic spindle checkpoint and prevents aneuploidy (PubMed:36702832). Negatively regulates cellular antiviral responses via deconjugating 'Lys-63'-linked ubiquitination of STING1 (PubMed:30943264). Significantly enhances the anti-HIV-1 activity of APOBEC3G. Mechanistically, stabilizes APOBEC3G by counteracting HIV-1 Vif-mediated APOBEC3G ubiquitination (PubMed:31397674)
Protein Sequence
10
MDRCKHVGRL
20
RLAQDHSILN
30
PQKWCCLECA
40
TTESVWACLK
50
CSHVACGRYI
60
EDHALKHFEE
70
TGHPLAMEVR
80
DLYVFCYLCK
90
DYVLNDNPEG
100
DLKLLRSSLL
110
AVRGQKQDTP
120
VRRGRTLRSM
130
ASGEDVVLPQ
140
RAPQGQPQML
150
TALWYRRQRL
160
LARTLRLWFE
170
KSSRGQAKLE
180
QRRQEEALER
190
KKEEARRRRR
200
EVKRRLLEEL
210
ASTPPRKSAR
220
LLLHTPRDAG
230
PAASRPAALP
240
TSRRVPAATL
250
KLRRQPAMAP
260
GVTGLRNLGN
270
TCYMNSILQV
280
LSHLQKFREC
290
FLNLDPSKTE
300
HLFPKATNGK
310
TQLSGKPTNS
320
SATELSLRND
330
RAEACEREGF
340
CWNGRASISR
350
SLELIQNKEP
360
SSKHISLCRE
370
LHTLFRVMWS
380
GKWALVSPFA
390
MLHSVWSLIP
400
AFRGYDQQDA
410
QEFLCELLHK
420
VQQELESEGT
430
TRRILIPFSQ
440
RKLTKQVLKV
450
VNTIFHGQLL
460
SQVTCISCNY
470
KSNTIEPFWD
480
LSLEFPERYH
490
CIEKGFVPLN
500
QTECLLTEML
510
AKFTETEALE
520
GRIYACDQCN
530
SKRRKSNPKP
540
LVLSEARKQL
550
MIYRLPQVLR
560
LHLKRFRWSG
570
RNHREKIGVH
580
VVFDQVLTME
590
PYCCRDMLSS
600
LDKETFAYDL
610
SAVVMHHGKG
620
FGSGHYTAYC
630
YNTEGGFWVH
640
CNDSKLNVCS
650
VEEVCKTQAY
660
ILFYTQRTVQ
670
GNARISETHL
680
QAQVQSSNND
EGRPQTFS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Molecular Function |
GO:0004843 |
cysteine-type deubiquitinase activity |
| Molecular Function |
GO:0004197 |
cysteine-type endopeptidase activity |
| Molecular Function |
GO:0042393 |
histone binding |
| Molecular Function |
GO:0140936 |
histone H2B deubiquitinase activity |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0000398 |
mRNA splicing, via spliceosome |
| Biological Process |
GO:0051898 |
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| Biological Process |
GO:0016579 |
protein deubiquitination |
| Biological Process |
GO:0006508 |
proteolysis |
Reference
PMID: N/A