Search Results

Overview

Uniprot IDQ70CQ2
Protein NameUbiquitin carboxyl-terminal hydrolase 34
Gene NameUSP34
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
3161 RVAINCEKFTETLVK

Function

Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins

Protein Sequence

10 MCENCADLVE 20 VLNEISDVEG 30 GDGLQLRKEH 40 TLKIFTYINS 50 WTQRQCLCCF 60 KEYKHLEIFN 70 QVVCALINLV 80 IAQVQVLRDQ 90 LCKHCTTINI 100 DSTWQDESNQ 110 AEEPLNIDRE 120 CNEGSTERQK 130 SIEKKSNSTR 140 ICNLTEEESS 150 KSSDPFSLWS 160 TDEKEKLLLC 170 VAKIFQIQFP 180 LYTAYKHNTH 190 PTIEDISTQE 200 SNILGAFCDM 210 NDVEVPLHLL 220 RYVCLFCGKN 230 GLSLMKDCFE 240 YGTPETLPFL 250 IAHAFITVVS 260 NIRIWLHIPA 270 VMQHIIPFRT 280 YVIRYLCKLS 290 DQELRQSAAR 300 NMADLMWSTV 310 KEPLDTTLCF 320 DKESLDLAFK 330 YFMSPTLTMR 340 LAGLSQITNQ 350 LHTFNDVCNN 360 ESLVSDTETS 370 IAKELADWLI 380 SNNVVEHIFG 390 PNLHIEIIKQ 400 CQVILNFLAA 410 EGRLSTQHID 420 CIWAAAQLKH 430 CSRYIHDLFP 440 SLIKNLDPVP 450 LRHLLNLVSA 460 LEPSVHTEQT 470 LYLASMLIKA 480 LWNNALAAKA 490 QLSKQSSFAS 500 LLNTNIPIGN 510 KKEEEELRRT 520 APSPWSPAAS 530 PQSSDNSDTH 540 QSGGSDIEMD 550 EQLINRTKHV 560 QQRLSDTEES 570 MQGSSDETAN 580 SGEDGSSGPG 590 SSSGHSDGSS 600 NEVNSSHASQ 610 SAGSPGSEVQ 620 SEDIADIEAL 630 KEEDEDDDHG 640 HNPPKSSCGT 650 DLRNRKLESQ 660 AGICLGDSQG 670 MSERNGTSSG 680 TGKDLVFNTE 690 SLPSVDNRMR 700 MLDACSHSED 710 PEHDISGEMN 720 ATHIAQGSQE 730 SCITRTGDFL 740 GETIGNELFN 750 CRQFIGPQHH 760 HHHHHHHHHH 770 DGHMVDDMLS 780 ADDVSCSSSQ 790 VSAKSEKNMA 800 DFDGEESGCE 810 EELVQINSHA 820 ELTSHLQQHL 830 PNLASIYHEH 840 LSQGPVVHKH 850 QFNSNAVTDI 860 NLDNVCKKGN 870 TLLWDIVQDE 880 DAVNLSEGLI 890 NEAEKLLCSL 900 VCWFTDRQIR 910 MRFIEGCLEN 920 LGNNRSVVIS 930 LRLLPKLFGT 940 FQQFGSSYDT 950 HWITMWAEKE 960 LNMMKLFFDN 970 LVYYIQTVRE 980 GRQKHALYSH 990 SAEVQVRLQF 1000 LTCVFSTLGS 1010 PDHFRLSLEQ 1020 VDILWHCLVE 1030 DSECYDDALH 1040 WFLNQVRSKD 1050 QHAMGMETYK 1060 HLFLEKMPQL 1070 KPETISMTGL 1080 NLFQHLCNLA 1090 RLATSAYDGC 1100 SNSELCGMDQ 1110 FWGIALRAQS 1120 GDVSRAAIQY 1130 INSYYINGKT 1140 GLEKEQEFIS 1150 KCMESLMIAS 1160 SSLEQESHSS 1170 LMVIERGLLM 1180 LKTHLEAFRR 1190 RFAYHLRQWQ 1200 IEGTGISSHL 1210 KALSDKQSLP 1220 LRVVCQPAGL 1230 PDKMTIEMYP 1240 SDQVADLRAE 1250 VTHWYENLQK 1260 EQINQQAQLQ 1270 EFGQSNRKGE 1280 FPGGLMGPVR 1290 MISSGHELTT 1300 DYDEKALHEL 1310 GFKDMQMVFV 1320 SLGAPRRERK 1330 GEGVQLPASC 1340 LPPPQKDNIP 1350 MLLLLQEPHL 1360 TTLFDLLEML 1370 ASFKPPSGKV 1380 AVDDSESLRC 1390 EELHLHAENL 1400 SRRVWELLML 1410 LPTCPNMLMA 1420 FQNISDEQSN 1430 DGFNWKELLK 1440 IKSAHKLLYA 1450 LEIIEALGKP 1460 NRRIRRESTG 1470 SYSDLYPDSD 1480 DSSEDQVENS 1490 KNSWSCKFVA 1500 AGGLQQLLEI 1510 FNSGILEPKE 1520 QESWTVWQLD 1530 CLACLLKLIC 1540 QFAVDPSDLD 1550 LAYHDVFAWS 1560 GIAESHRKRT 1570 WPGKSRKAAG 1580 DHAKGLHIPR 1590 LTEVFLVLVQ 1600 GTSLIQRLMS 1610 VAYTYDNLAP 1620 RVLKAQSDHR 1630 SRHEVSHYSM 1640 WLLVSWAHCC 1650 SLVKSSLADS 1660 DHLQDWLKKL 1670 TLLIPETAVR 1680 HESCSGLYKL 1690 SLSGLDGGDS 1700 INRSFLLLAA 1710 STLLKFLPDA 1720 QALKPIRIDD 1730 YEEEPILKPG 1740 CKEYFWLLCK 1750 LVDNIHIKDA 1760 SQTTLLDLDA 1770 LARHLADCIR 1780 SREILDHQDG 1790 NVEDDGLTGL 1800 LRLATSVVKH 1810 KPPFKFSREG 1820 QEFLRDIFNL 1830 LFLLPSLKDR 1840 QQPKCKSHSS 1850 RAAAYDLLVE 1860 MVKGSVENYR 1870 LIHNWVMAQH 1880 MQSHAPYKWD 1890 YWPHEDVRAE 1900 CRFVGLTNLG 1910 ATCYLASTIQ 1920 QLYMIPEARQ 1930 AVFTAKYSED 1940 MKHKTTLLEL 1950 QKMFTYLMES 1960 ECKAYNPRPF 1970 CKTYTMDKQP 1980 LNTGEQKDMT 1990 EFFTDLITKI 2000 EEMSPELKNT 2010 VKSLFGGVIT 2020 NNVVSLDCEH 2030 VSQTAEEFYT 2040 VRCQVADMKN 2050 IYESLDEVTI 2060 KDTLEGDNMY 2070 TCSHCGKKVR 2080 AEKRACFKKL 2090 PRILSFNTMR 2100 YTFNMVTMMK 2110 EKVNTHFSFP 2120 LRLDMTPYTE 2130 DFLMGKSERK 2140 EGFKEVSDHS 2150 KDSESYEYDL 2160 IGVTVHTGTA 2170 DGGHYYSFIR 2180 DIVNPHAYKN 2190 NKWYLFNDAE 2200 VKPFDSAQLA 2210 SECFGGEMTT 2220 KTYDSVTDKF 2230 MDFSFEKTHS 2240 AYMLFYKRME 2250 PEEENGREYK 2260 FDVSSELLEW 2270 IWHDNMQFLQ 2280 DKNIFEHTYF 2290 GFMWQLCSCI 2300 PSTLPDPKAV 2310 SLMTAKLSTS 2320 FVLETFIHSK 2330 EKPTMLQWIE 2340 LLTKQFNNSQ 2350 AACEWFLDRM 2360 ADDDWWPMQI 2370 LIKCPNQIVR 2380 QMFQRLCIHV 2390 IQRLRPVHAH 2400 LYLQPGMEDG 2410 SDDMDTSVED 2420 IGGRSCVTRF 2430 VRTLLLIMEH 2440 GVKPHSKHLT 2450 EYFAFLYEFA 2460 KMGEEESQFL 2470 LSLQAISTMV 2480 HFYMGTKGPE 2490 NPQVEVLSEE 2500 EGEEEEEEED 2510 ILSLAEEKYR 2520 PAALEKMIAL 2530 VALLVEQSRS 2540 ERHLTLSQTD 2550 MAALTGGKGF 2560 PFLFQHIRDG 2570 INIRQTCNLI 2580 FSLCRYNNRL 2590 AEHIVSMLFT 2600 SIAKLTPEAA 2610 NPFFKLLTML 2620 MEFAGGPPGM 2630 PPFASYILQR 2640 IWEVIEYNPS 2650 QCLDWLAVQT 2660 PRNKLAHSWV 2670 LQNMENWVER 2680 FLLAHNYPRV 2690 RTSAAYLLVS 2700 LIPSNSFRQM 2710 FRSTRSLHIP 2720 TRDLPLSPDT 2730 TVVLHQVYNV 2740 LLGLLSRAKL 2750 YVDAAVHGTT 2760 KLVPYFSFMT 2770 YCLISKTEKL 2780 MFSTYFMDLW 2790 NLFQPKLSEP 2800 AIATNHNKQA 2810 LLSFWYNVCA 2820 DCPENIRLIV 2830 QNPVVTKNIA 2840 FNYILADHDD 2850 QDVVLFNRGM 2860 LPAYYGILRL 2870 CCEQSPAFTR 2880 QLASHQNIQW 2890 AFKNLTPHAS 2900 QYPGAVEELF 2910 NLMQLFIAQR 2920 PDMREEELED 2930 IKQFKKTTIS 2940 CYLRCLDGRS 2950 CWTTLISAFR 2960 ILLESDEDRL 2970 LVVFNRGLIL 2980 MTESFNTLHM 2990 MYHEATACHV 3000 TGDLVELLSI 3010 FLSVLKSTRP 3020 YLQRKDVKQA 3030 LIQWQERIEF 3040 AHKLLTLLNS 3050 YSPPELRNAC 3060 IDVLKELVLL 3070 SPHDFLHTLV 3080 PFLQHNHCTY 3090 HHSNIPMSLG 3100 PYFPCRENIK 3110 LIGGKSNIRP 3120 PRPELNMCLL 3130 PTMVETSKGK 3140 DDVYDRMLLD 3150 YFFSYHQFIH 3160 LLCRVAINCE 3170 KFTETLVKLS 3180 VLVAYEGLPL 3190 HLALFPKLWT 3200 ELCQTQSAMS 3210 KNCIKLLCED 3220 PVFAEYIKCI 3230 LMDERTFLNN 3240 NIVYTFMTHF 3250 LLKVQSQVFS 3260 EANCANLIST 3270 LITNLISQYQ 3280 NLQSDFSNRV 3290 EISKASASLN 3300 GDLRALALLL 3310 SVHTPKQLNP 3320 ALIPTLQELL 3330 SKCRTCLQQR 3340 NSLQEQEAKE 3350 RKTKDDEGAT 3360 PIKRRRVSSD 3370 EEHTVDSCIS 3380 DMKTETREVL 3390 TPTSTSDNET 3400 RDSSIIDPGT 3410 EQDLPSPENS 3420 SVKEYRMEVP 3430 SSFSEDMSNI 3440 RSQHAEEQSN 3450 NGRYDDCKEF 3460 KDLHCSKDST 3470 LAEEESEFPS 3480 TSISAVLSDL 3490 ADLRSCDGQA 3500 LPSQDPEVAL 3510 SLSCGHSRGL 3520 FSHMQQHDIL 3530 DTLCRTIEST 3540 IHVVTRISGK GNQAAS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005634 nucleus
Molecular Function GO:0004843 cysteine-type deubiquitinase activity
Molecular Function GO:0004197 cysteine-type endopeptidase activity
Biological Process GO:0090263 positive regulation of canonical Wnt signaling pathway
Biological Process GO:0016579 protein deubiquitination
Biological Process GO:0071108 protein K48-linked deubiquitination
Biological Process GO:0006508 proteolysis
Biological Process GO:0031647 regulation of protein stability
Biological Process GO:0016055 Wnt signaling pathway

Reference

PMID: N/A