Search Results

Overview

Uniprot IDQ70EL1
Protein NameUbiquitin carboxyl-terminal hydrolase 54
Gene NameUSP54
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1161 SLSGSLRKNSSPSDS

Function

Deubiquitinase that specifically mediates 'Lys-63'-linked deubiquitination of substrates with a polyubiquitin chain composed of at least 3 ubiquitins (PubMed:39587316). Specifically recognizes ubiquitin chain in position S2 and catalyzes cleavage of polyubiquitin within 'Lys-63'-linked chains (PubMed:39587316). Not able to deubiquitinate substrates with shorter ubiquitin chains (PubMed:39587316). Mediates deubiquitination of PLK4, maintaining PLK4 stability by reducing its ubiquitination-mediated degradation (PubMed:36590171)

Protein Sequence

10 MSWKRNYFSG 20 GRGSVQGMFA 30 PRSSTSIAPS 40 KGLSNEPGQN 50 SCFLNSALQV 60 LWHLDIFRRS 70 FRQLTTHKCM 80 GDSCIFCALK 90 GIFNQFQCSS 100 EKVLPSDTLR 110 SALAKTFQDE 120 QRFQLGIMDD 130 AAECFENLLM 140 RIHFHIADET 150 KEDICTAQHC 160 ISHQKFAMTL 170 FEQCVCTSCG 180 ATSDPLPFIQ 190 MVHYISTTSL 200 CNQAICMLER 210 REKPSPSMFG 220 ELLQNASTMG 230 DLRNCPSNCG 240 ERIRIRRVLM 250 NAPQIITIGL 260 VWDSDHSDLA 270 EDVIHSLGTC 280 LKLGDLFFRV 290 TDDRAKQSEL 300 YLVGMICYYG 310 KHYSTFFFQT 320 KIRKWMYFDD 330 AHVKEIGPKW 340 KDVVTKCIKG 350 HYQPLLLLYA 360 DPQGTPVSTQ 370 DLPPQAEFQS 380 YSRTCYDSED 390 SGREPSISSD 400 TRTDSSTESY 410 PYKHSHHESV 420 VSHFSSDSQG 430 TVIYNVENDS 440 MSQSSRDTGH 450 LTDSECNQKH 460 TSKKGSLIER 470 KRSSGRVRRK 480 GDEPQASGYH 490 SEGETLKEKQ 500 APRNASKPSS 510 STNRLRDFKE 520 TVSNMIHNRP 530 SLASQTNVGS 540 HCRGRGGDQP 550 DKKPPRTLPL 560 HSRDWEIEST 570 SSESKSSSSS 580 KYRPTWRPKR 590 ESLNIDSIFS 600 KDKRKHCGYT 610 QLSPFSEDSA 620 KEFIPDEPSK 630 PPSYDIKFGG 640 PSPQYKRWGP 650 ARPGSHLLEQ 660 HPRLIQRMES 670 GYESSERNSS 680 SPVSLDAALP 690 ESSNVYRDPS 700 AKRSAGLVPS 710 WRHIPKSHSS 720 SILEVDSTAS 730 MGGWTKSQPF 740 SGEEISSKSE 750 LDELQEEVAR 760 RAQEQELRRK 770 REKELEAAKG 780 FNPHPSRFMD 790 LDELQNQGRS 800 DGFERSLQEA 810 ESVFEESLHL 820 EQKGDCAAAL 830 ALCNEAISKL 840 RLALHGASCS 850 THSRALVDKK 860 LQISIRKARS 870 LQDRMQQQQS 880 PQQPSQPSAC 890 LPTQAGTLSQ 900 PTSEQPIPLQ 910 VLLSQEAQLE 920 SGMDTEFGAS 930 SFFHSPASCH 940 ESHSSLSPES 950 SAPQHSSPSR 960 SALKLLTSVE 970 VDNIEPSAFH 980 RQGLPKAPGW 990 TEKNSHHSWE 1000 PLDAPEGKLQ 1010 GSRCDNSSCS 1020 KLPPQEGRGI 1030 AQEQLFQEKK 1040 DPANPSPVMP 1050 GIATSERGDE 1060 HSLGCSPSNS 1070 SAQPSLPLYR 1080 TCHPIMPVAS 1090 SFVLHCPDPV 1100 QKTNQCLQGQ 1110 SLKTSLTLKV 1120 DRGSEETYRP 1130 EFPSTKGLVR 1140 SLAEQFQRMQ 1150 GVSMRDSTGF 1160 KDRSLSGSLR 1170 KNSSPSDSKP 1180 PFSQGQEKGH 1190 WPWAKQQSSL 1200 EGGDRPLSWE 1210 ESTEHSSLAL 1220 NSGLPNGETS 1230 SGGQPRLAEP 1240 DIYQEKLSQV 1250 RDVRSKDLGS 1260 STDLGTSLPL 1270 DSWVNITRFC 1280 DSQLKHGAPR 1290 PGMKSSPHDS 1300 HTCVTYPERN 1310 HILLHPHWNQ 1320 DTEQETSELE 1330 SLYQASLQAS 1340 QAGCSGWGQQ 1350 DTAWHPLSQT 1360 GSADGMGRRL 1370 HSAHDPGLSK 1380 TSTAEMEHGL 1390 HEARTVRTSQ 1400 ATPCRGLSRE 1410 CGEDEQYSAE 1420 NLRRISRSLS 1430 GTVVSEREEA 1440 PVSSHSFDSS 1450 NVRKPLETGH 1460 RCSSSSSLPV 1470 IHDPSVFLLG 1480 PQLYLPQPQF 1490 LSPDVLMPTM 1500 AGEPNRLPGT 1510 SRSVQQFLAM 1520 CDRGETSQGA 1530 KYTGRTLNYQ 1540 SLPHRSRTDN 1550 SWAPWSETNQ 1560 HIGTRFLTTP 1570 GCNPQLTYTA 1580 TLPERSKGLQ 1590 VPHTQSWSDL 1600 FHSPSHPPIV 1610 HPVYPPSSSL 1620 HVPLRSAWNS 1630 DPVPGSRTPG 1640 PRRVDMPPDD 1650 DWRQSSYASH 1660 SGHRRTVGEG 1670 FLFVLSDAPR 1680 REQIRARVLQ HSQW

Gene Ontology

Classification GO ID Description
Molecular Function GO:0004843 cysteine-type deubiquitinase activity
Molecular Function GO:0061578 K63-linked deubiquitinase activity
Biological Process GO:0016579 protein deubiquitination
Biological Process GO:0006508 proteolysis

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.