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Overview

Uniprot IDQ70EL2
Protein NameUbiquitin carboxyl-terminal hydrolase 45
Gene NameUSP45
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
767 LSEHNTKKKNVPGLK
768 SEHNTKKKNVPGLKA
774 KKNVPGLKAADNESA

Function

Catalyzes the deubiquitination of SPDL1 (PubMed:30258100). Plays a role in the repair of UV-induced DNA damage via deubiquitination of ERCC1, promoting its recruitment to DNA damage sites (PubMed:25538220). May be involved in the maintenance of photoreceptor function (PubMed:30573563). May play a role in normal retinal development (By similarity). Plays a role in cell migration (PubMed:30258100)

Protein Sequence

10 MRVKDPTKAL 20 PEKAKRSKRP 30 TVPHDEDSSD 40 DIAVGLTCQH 50 VSHAISVNHV 60 KRAIAENLWS 70 VCSECLKERR 80 FYDGQLVLTS 90 DIWLCLKCGF 100 QGCGKNSESQ 110 HSLKHFKSSR 120 TEPHCIIINL 130 STWIIWCYEC 140 DEKLSTHCNK 150 KVLAQIVDFL 160 QKHASKTQTS 170 AFSRIMKLCE 180 EKCETDEIQK 190 GGKCRNLSVR 200 GITNLGNTCF 210 FNAVMQNLAQ 220 TYTLTDLMNE 230 IKESSTKLKI 240 FPSSDSQLDP 250 LVVELSRPGP 260 LTSALFLFLH 270 SMKETEKGPL 280 SPKVLFNQLC 290 QKAPRFKDFQ 300 QQDSQELLHY 310 LLDAVRTEET 320 KRIQASILKA 330 FNNPTTKTAD 340 DETRKKVKAY 350 GKEGVKMNFI 360 DRIFIGELTS 370 TVMCEECANI 380 STVKDPFIDI 390 SLPIIEERVS 400 KPLLWGRMNK 410 YRSLRETDHD 420 RYSGNVTIEN 430 IHQPRAAKKH 440 SSSKDKSQLI 450 HDRKCIRKLS 460 SGETVTYQKN 470 ENLEMNGDSL 480 MFASLMNSES 490 RLNESPTDDS 500 EKEASHSESN 510 VDADSEPSES 520 ESASKQTGLF 530 RSSSGSGVQP 540 DGPLYPLSAG 550 KLLYTKETDS 560 GDKEMAEAIS 570 ELRLSSTVTG 580 DQDFDRENQP 590 LNISNNLCFL 600 EGKHLRSYSP 610 QNAFQTLSQS 620 YITTSKECSI 630 QSCLYQFTSM 640 ELLMGNNKLL 650 CENCTKNKQK 660 YQEETSFAEK 670 KVEGVYTNAR 680 KQLLISAVPA 690 VLILHLKRFH 700 QAGLSLRKVN 710 RHVDFPLMLD 720 LAPFCSATCK 730 NASVGDKVLY 740 GLYGIVEHSG 750 SMREGHYTAY 760 VKVRTPSRKL 770 SEHNTKKKNV 780 PGLKAADNES 790 AGQWVHVSDT 800 YLQVVPESRA 810 LSAQAYLLFY ERVL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0001917 photoreceptor inner segment
Molecular Function GO:0004843 cysteine-type deubiquitinase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0016477 cell migration
Biological Process GO:0006281 DNA repair
Biological Process GO:0070911 global genome nucleotide-excision repair
Biological Process GO:0003407 neural retina development
Biological Process GO:0045494 photoreceptor cell maintenance
Biological Process GO:0016579 protein deubiquitination
Biological Process GO:0006508 proteolysis

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.