Search Results
Overview
| Uniprot ID | Q712U6 |
|---|---|
| Protein Name | cAMP-regulated phosphoprotein 19 |
| Gene Name | ARPP19 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 26 | DKVTSPEKAEEAKLK |
| 75 | AKAKMKNKQLPTAAP |
| 84 | LPTAAPDKTEVTGDH |
Function
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis (By similarity). Inhibition of PP2A is enhanced when ARPP19 is phosphorylated (By similarity). When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity). May indirectly enhance GAP-43 expression by binding to the NGF-regulatory region of its mRNA (By similarity)
Protein Sequence
10
MSAEVPEAAS
20
AEEQKEMEDK
30
VTSPEKAEEA
40
KLKARYPHLG
50
QKPGGSDFLR
60
KRLQKGQKYF
70
DSGDYNMAKA
80
KMKNKQLPTA
90
APDKTEVTGD
100
HIPTPQDLPQ
110
RKPSLVASKL
AG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0019212 | phosphatase inhibitor activity |
| Molecular Function | GO:0015459 | potassium channel regulator activity |
| Molecular Function | GO:0051721 | protein phosphatase 2A binding |
| Molecular Function | GO:0004864 | protein phosphatase inhibitor activity |
| Molecular Function | GO:0019888 | protein phosphatase regulator activity |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0000086 | G2/M transition of mitotic cell cycle |
| Biological Process | GO:0000278 | mitotic cell cycle |
| Biological Process | GO:0045722 | positive regulation of gluconeogenesis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.