Search Results
Overview
| Uniprot ID | Q71F23 |
|---|---|
| Protein Name | Centromere protein U |
| Gene Name | CENPU |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 131 | SAKKPGRKLRPISDD |
| 156 | RKVKSAEKISTQRHE |
| 185 | AESVTSKKTGPLSAQ |
Function
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression
Protein Sequence
10
MAPRGRRRPR
20
PHRSEGARRS
30
KNTLERTHSM
40
KDKAGQKCKP
50
IDVFDFPDNS
60
DVSSIGRLGE
70
NEKDEETYET
80
FDPPLHSTAI
90
YADEEEFSKH
100
CGLSLSSTPP
110
GKEAKRSSDT
120
SGNEASEIES
130
VKISAKKPGR
140
KLRPISDDSE
150
SIEESDTRRK
160
VKSAEKISTQ
170
RHEVIRTTAS
180
SELSEKPAES
190
VTSKKTGPLS
200
AQPSVEKENL
210
AIESQSKTQK
220
KGKISHDKRK
230
KSRSKAIGSD
240
TSDIVHIWCP
250
EGMKTSDIKE
260
LNIVLPEFEK
270
THLEHQQRIE
280
SKVCKAAIAT
290
FYVNVKEQFI
300
KMLKESQMLT
310
NLKRKNAKMI
320
SDIEKKRQRM
330
IEVQDELLRL
340
EPQLKQLQTK
350
YDELKERKSS
360
LRNAAYFLSN
370
LKQLYQDYSD
380
VQAQEPNVKE
390
TYDSSSLPAL
400
LFKARTLLGA
410
ESHLRNINHQ
LEKLLDQG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0034451 | centriolar satellite |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:0005654 | nucleoplasm |
| Biological Process | GO:0007059 | chromosome segregation |
| Biological Process | GO:0006351 | DNA-templated transcription |
Reference
PMID: N/A