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Overview

Uniprot IDQ71F56
Protein NameMediator of RNA polymerase II transcription subunit 13-like
Gene NameMED13L
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
527 SSSRKYDKQMAVPSR
746 KDSLKKNKSEDGFGT
833 SPALRSSKMPAVGTE

Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway

Protein Sequence

10 MTAAANWVAN 20 GASLEDCHSN 30 LFSLAELTGI 40 KWRRYNFGGH 50 GDCGPIISAP 60 AQDDPILLSF 70 IRCLQANLLC 80 VWRRDVKPDC 90 KELWIFWWGD 100 EPNLVGVIHH 110 ELQVVEEGLW 120 ENGLSYECRT 130 LLFKAIHNLL 140 ERCLMDKNFV 150 RIGKWFVRPY 160 EKDEKPVNKS 170 EHLSCAFTFF 180 LHGESNVCTS 190 VEIAQHQPIY 200 LINEEHIHMA 210 QSSPAPFQVL 220 VSPYGLNGTL 230 TGQAYKMSDP 240 ATRKLIEEWQ 250 YFYPMVLKKK 260 EESKEEDELG 270 YDDDFPVAVE 280 VIVGGVRMVY 290 PSAFVLISQN 300 DIPVPQSVAS 310 AGGHIAVGQQ 320 GLGSVKDPSN 330 CGMPLTPPTS 340 PEQAILGESG 350 GMQSAASHLV 360 SQDGGMITMH 370 SPKRSGKIPP 380 KLHNHMVHRV 390 WKECILNRTQ 400 SKRSQMSTPT 410 LEEEPASNPA 420 TWDFVDPTQR 430 VSCSCSRHKL 440 LKRCAVGPNR 450 PPTVSQPGFS 460 AGPSSSSSLP 470 PPASSKHKTA 480 ERQEKGDKLQ 490 KRPLIPFHHR 500 PSVAEELCME 510 QDTPGQKLGL 520 AGIDSSLEVS 530 SSRKYDKQMA 540 VPSRNTSKQM 550 NLNPMDSPHS 560 PISPLPPTLS 570 PQPRGQETES 580 LDPPSVPVNP 590 ALYGNGLELQ 600 QLSTLDDRTV 610 LVGQRLPLMA 620 EVSETALYCG 630 IRPSNPESSE 640 KWWHSYRLPP 650 SDDAEFRPPE 660 LQGERCDAKM 670 EVNSESTALQ 680 RLLAQPNKRF 690 KIWQDKQPQL 700 QPLHFLDPLP 710 LSQQPGDSLG 720 EVNDPYTFED 730 GDIKYIFTAN 740 KKCKQGTEKD 750 SLKKNKSEDG 760 FGTKDVTTPG 770 HSTPVPDGKN 780 AMSIFSSATK 790 TDVRQDNAAG 800 RAGSSSLTQV 810 TDLAPSLHDL 820 DNIFDNSDDD 830 ELGAVSPALR 840 SSKMPAVGTE 850 DRPLGKDGRA 860 AVPYPPTVAD 870 LQRMFPTPPS 880 LEQHPAFSPV 890 MNYKDGISSE 900 TVTALGMMES 910 PMVSMVSTQL 920 TEFKMEVEDG 930 LGSPKPEEIK 940 DFSYVHKVPS 950 FQPFVGSSMF 960 APLKMLPSHC 970 LLPLKIPDAC 980 LFRPSWAIPP 990 KIEQLPMPPA 1000 ATFIRDGYNN 1010 VPSVGSLADP 1020 DYLNTPQMNT 1030 PVTLNSAAPA 1040 SNSGAGVLPS 1050 PATPRFSVPT 1060 PRTPRTPRTP 1070 RGGGTASGQG 1080 SVKYDSTDQG 1090 SPASTPSTTR 1100 PLNSVEPATM 1110 QPIPEAHSLY 1120 VTLILSDSVM 1130 NIFKDRNFDS 1140 CCICACNMNI 1150 KGADVGLYIP 1160 DSSNEDQYRC 1170 TCGFSAIMNR 1180 KLGYNSGLFL 1190 EDELDIFGKN 1200 SDIGQAAERR 1210 LMMCQSTFLP 1220 QVEGTKKPQE 1230 PPISLLLLLQ 1240 NQHTQPFASL 1250 NFLDYISSNN 1260 RQTLPCVSWS 1270 YDRVQADNND 1280 YWTECFNALE 1290 QGRQYVDNPT 1300 GGKVDEALVR 1310 SATVHSWPHS 1320 NVLDISMLSS 1330 QDVVRMLLSL 1340 QPFLQDAIQK 1350 KRTGRTWENI 1360 QHVQGPLTWQ 1370 QFHKMAGRGT 1380 YGSEESPEPL 1390 PIPTLLVGYD 1400 KDFLTISPFS 1410 LPFWERLLLD 1420 PYGGHRDVAY 1430 IVVCPENEAL 1440 LEGAKTFFRD 1450 LSAVYEMCRL 1460 GQHKPICKVL 1470 RDGIMRVGKT 1480 VAQKLTDELV 1490 SEWFNQPWSG 1500 EENDNHSRLK 1510 LYAQVCRHHL 1520 APYLATLQLD 1530 SSLLIPPKYQ 1540 TPPAAAQGQA 1550 TPGNAGPLAP 1560 NGSAAPPAGS 1570 AFNPTSNSSS 1580 TNPAASSSAS 1590 GSSVPPVSSS 1600 ASAPGISQIS 1610 TTSSSGFSGS 1620 VGGQNPSTGG 1630 ISADRTQGNI 1640 GCGGDTDPGQ 1650 SSSQPSQDGQ 1660 ESVTERERIG 1670 IPTEPDSADS 1680 HAHPPAVVIY 1690 MVDPFTYAAE 1700 EDSTSGNFWL 1710 LSLMRCYTEM 1720 LDNLPEHMRN 1730 SFILQIVPCQ 1740 YMLQTMKDEQ 1750 VFYIQYLKSM 1760 AFSVYCQCRR 1770 PLPTQIHIKS 1780 LTGFGPAASI 1790 EMTLKNPERP 1800 SPIQLYSPPF 1810 ILAPIKDKQT 1820 ELGETFGEAS 1830 QKYNVLFVGY 1840 CLSHDQRWLL 1850 ASCTDLHGEL 1860 LETCVVNIAL 1870 PNRSRRSKVS 1880 ARKIGLQKLW 1890 EWCIGIVQMT 1900 SLPWRVVIGR 1910 LGRLGHGELK 1920 DWSILLGECS 1930 LQTISKKLKD 1940 VCRMCGISAA 1950 DSPSILSACL 1960 VAMEPQGSFV 1970 VMPDAVTMGS 1980 VFGRSTALNM 1990 QSSQLNTPQD 2000 ASCTHILVFP 2010 TSSTIQVAPA 2020 NYPNEDGFSP 2030 NNDDMFVDLP 2040 FPDDMDNDIG 2050 ILMTGNLHSS 2060 PNSSPVPSPG 2070 SPSGIGVGSH 2080 FQHSRSQGER 2090 LLSREAPEEL 2100 KQQPLALGYF 2110 VSTAKAENLP 2120 QWFWSSCPQA 2130 QNQCPLFLKA 2140 SLHHHISVAQ 2150 TDELLPARNS 2160 QRVPHPLDSK 2170 TTSDVLRFVL 2180 EQYNALSWLT 2190 CNPATQDRTS 2200 CLPVHFVVLT 2210 QLYNAIMNIL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016592 mediator complex
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0003713 transcription coactivator activity
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II

Reference

PMID: N/A