Overview
| Uniprot ID | Q71RI9 |
|---|
| Protein Name | Kynurenine--oxoglutarate transaminase 3 |
|---|
| Gene Name | Kyat3 |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 117 |
ALSCLYGKIYQRQID |
Function
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others (PubMed:19029248). May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (PubMed:19029248). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro) (PubMed:19029248)
Protein Sequence
10
MLLAQRRLIS
20
LGCRSKPIKT
30
IYSSSKVLGL
40
CTSAKMALKF
50
KNAKRIEGLD
60
SNVWVEFTKL
70
AADPSVVNLG
80
QGFPDISPPS
90
YVKEELSKAA
100
FIDNMNQYTR
110
GFGHPALVKA
120
LSCLYGKIYQ
130
RQIDPNEEIL
140
VAVGAYGSLF
150
NSIQGLVDPG
160
DEVIIMVPFY
170
DCYEPMVRMA
180
GAVPVFIPLR
190
SKPTDGMKWT
200
SSDWTFDPRE
210
LESKFSSKTK
220
AIILNTPHNP
230
LGKVYTRQEL
240
QVIADLCVKH
250
DTLCISDEVY
260
EWLVYTGHTH
270
VKIATLPGMW
280
ERTITIGSAG
290
KTFSVTGWKL
300
GWSIGPAHLI
310
KHLQTVQQNS
320
FYTCATPLQA
330
ALAEAFWIDI
340
KRMDDPECYF
350
NSLPKELEVK
360
RDRMVRLLNS
370
VGLKPIVPDG
380
GYFIIADVSS
390
LGADLSDMNS
400
DEPYDYKFVK
410
WMTKHKKLTA
420
IPVSAFCDSK
430
SKPHFEKLVR
440
FCFIKKDSTL
450
DAAEEIFRAW
NSQKS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Molecular Function |
GO:0047804 |
cysteine-S-conjugate beta-lyase activity |
| Molecular Function |
GO:0047315 |
kynurenine-glyoxylate transaminase activity |
| Molecular Function |
GO:0016212 |
kynurenine-oxoglutarate transaminase activity |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Molecular Function |
GO:0030170 |
pyridoxal phosphate binding |
| Biological Process |
GO:0006103 |
2-oxoglutarate metabolic process |
| Biological Process |
GO:0006520 |
amino acid metabolic process |
| Biological Process |
GO:0070189 |
kynurenine metabolic process |
| Biological Process |
GO:0097053 |
L-kynurenine catabolic process |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.