Search Results
Overview
| Uniprot ID | Q71SY5 |
|---|---|
| Protein Name | Mediator of RNA polymerase II transcription subunit 25 |
| Gene Name | MED25 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 551 | HKQVQQQKLEQQQRG |
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription
Protein Sequence
10
MVPGSEGPAR
20
AGSVVADVVF
30
VIEGTANLGP
40
YFEGLRKHYL
50
LPAIEYFNGG
60
PPAETDFGGD
70
YGGTQYSLVV
80
FNTVDCAPES
90
YVQCHAPTSS
100
AYEFVTWLDG
110
IKFMGGGGES
120
CSLIAEGLST
130
ALQLFDDFKK
140
MREQIGQTHR
150
VCLLICNSPP
160
YLLPAVESTT
170
YSGCTTENLV
180
QQIGERGIHF
190
SIVSPRKLPA
200
LRLLFEKAAP
210
PALLEPLQPP
220
TDVSQDPRHM
230
VLVRGLVLPV
240
GGGSAPGPLQ
250
SKQPVPLPPA
260
APSGATLSAA
270
PQQPLPPVPP
280
QYQVPGNLSA
290
AQVAAQNAVE
300
AAKNQKAGLG
310
PRFSPITPLQ
320
QAAPGVGPPF
330
SQAPAPQLPP
340
GPPGAPKPPP
350
ASQPSLVSTV
360
APGSGLAPTA
370
QPGAPSMAGT
380
VAPGGVSGPS
390
PAQLGAPALG
400
GQQSVSNKLL
410
AWSGVLEWQE
420
KPKPASVDAN
430
TKLTRSLPCQ
440
VYVNHGENLK
450
TEQWPQKLIM
460
QLIPQQLLTT
470
LGPLFRNSRM
480
VQFHFTNKDL
490
ESLKGLYRIM
500
GNGFAGCVHF
510
PHTAPCEVRV
520
LMLLYSSKKK
530
IFMGLIPYDQ
540
SGFVNGIRQV
550
ITNHKQVQQQ
560
KLEQQQRGMG
570
GQQAPPGLGP
580
ILEDQARPSQ
590
NLLQLRPPQP
600
QPQGTVGASG
610
ATGQPQPQGT
620
AQPPPGAPQG
630
PPGAASGPPP
640
PGPILRPQNP
650
GANPQLRSLL
660
LNPPPPQTGV
670
PPPQASLHHL
680
QPPGAPALLP
690
PPHQGLGQPQ
700
LGPPLLHPPP
710
AQSWPAQLPP
720
RAPLPGQMLL
730
SGGPRGPVPQ
740
PGLQPSVMED
DILMDLI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0016592 | mediator complex |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005667 | transcription regulator complex |
| Molecular Function | GO:0042974 | nuclear retinoic acid receptor binding |
| Molecular Function | GO:0046965 | nuclear retinoid X receptor binding |
| Molecular Function | GO:0001223 | transcription coactivator binding |
| Biological Process | GO:0048147 | negative regulation of fibroblast proliferation |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0035563 | positive regulation of chromatin binding |
| Biological Process | GO:2001178 | positive regulation of mediator complex assembly |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0032968 | positive regulation of transcription elongation by RNA polymerase II |
| Biological Process | GO:0060261 | positive regulation of transcription initiation by RNA polymerase II |
| Biological Process | GO:0051123 | RNA polymerase II preinitiation complex assembly |
Reference
PMID: N/A