Search Results

Overview

Uniprot ID	Q75HE6
Protein Name	Probable methylenetetrahydrofolate reductase (NADH)
Gene Name	Os03g0815200
Organism	Oryza sativa subsp. japonica

Kla Sites from experimental identification

Position	Flanking peptide
273	LGTEMCKKILATGIK

Function

The probable reversibility of the MTHFR reaction in plants suggests that they can metabolize the methyl group of 5,10-methylenetetrahydrofolate to serine, sugars and starch

Protein Sequence

10 MKVIEKIQEA 20 AADGRTVFSF 30 EYFPPKTEEG 40 LDNLFERMDR 50 MVAHGPNFCD 60 ITWGAGGSTA 70 DLTLEIANRM 80 QNMVCVETMM 90 HLTCTNMPVE 100 KIDDALTTIK 110 SNGIQNVLAL 120 RGDPPHGQDK 130 FVQVAGGFAC 140 ALDLVQHIRA 150 KYGDYFGITV 160 AGYPEAHPDA 170 IQSTEGATPE 180 AYSNDLAYLK 190 QKVDAGADLI 200 ITQLFYDTDI 210 FLKFVNDCRQ 220 IGITCPIVPG 230 IMPINNYKGF 240 LRMTGFCKTK 250 IPAEITAALE 260 PIKDNEEAVK 270 AYGIHLGTEM 280 CKKILATGIK 290 TLHLYTLNME 300 KSALGILMNL 310 GLIEESKISR 320 SLPWRPPTNV 330 FRVKEDVRPI 340 FWANRPKSYI 350 SRTLGWDQYP 360 HGRWGDSRNP 370 SYGALTDYQF 380 TRPRGRGKKL 390 QEEWAVPVKS 400 VEDINERFMN 410 FCQGKLTSSP 420 WSELDGLQPE 430 TKIIDDQLVK 440 INQKGFLTIN 450 SQPAVNGERS 460 DSTSVGWGGP 470 GGYVYQKAYL 480 EFFCSKEKLD 490 QLIEKSKAFP 500 SLTYIAVNKD 510 GESFSNIPTN 520 AVNAVTWGVF 530 PGKEIVQPTV 540 VDSASFMVWK 550 DEAFEIWSKG 560 WACLFPEGDS 570 SREILDKVQK 580 SYFLVSLVDN 590 DYINGDLFAA FKEI

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Molecular Function	GO:0071949	FAD binding
Molecular Function	GO:0106312	methylenetetrahydrofolate reductase (NADH) activity
Molecular Function	GO:0004489	methylenetetrahydrofolate reductase [NAD(P)H] activity
Biological Process	GO:0009086	methionine biosynthetic process
Biological Process	GO:0035999	tetrahydrofolate interconversion

Reference

[1] Meng X, Baine JM, Yan T, Wang S. Comprehensive Analysis of Lysine Lactylation in Rice (Oryza sativa) Grains.. J Agric Food Chem 69(29):8287-8297. 2021 Jul 28. PMID: 34264677.