Search Results

Overview

Uniprot IDQ75N03
Protein NameE3 ubiquitin-protein ligase Hakai
Gene NameCBLL1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
288 TFRISTRKHSNLITV
29 VRRRIPIKLISKQAN
33 IPIKLISKQANKAKP
74 EEERYDCKGGELFAN

Function

E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity). Targets CDH1 for endocytosis and degradation (By similarity). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Its function in the WMM complex is unknown (PubMed:29507755)

Protein Sequence

10 MDHTDNELQG 20 TNSSGSLGGL 30 DVRRRIPIKL 40 ISKQANKAKP 50 APRTQRTINR 60 MPAKAPPGDE 70 EGFDYNEEER 80 YDCKGGELFA 90 NQRRFPGHLF 100 WDFQINILGE 110 KDDTPVHFCD 120 KCGLPIKIYG 130 RMIPCKHVFC 140 YDCAILHEKK 150 GDKMCPGCSD 160 PVQRIEQCTR 170 GSLFMCSIVQ 180 GCKRTYLSQR 190 DLQAHINHRH 200 MRAGKPVTRA 210 SLENVHPPIA 220 PPPTEIPERF 230 IMPPDKHHMS 240 HIPPKQHIMM 250 PPPPLQHVPH 260 EHYNQPHEDI 270 RAPPAELSMA 280 PPPPRSVSQE 290 TFRISTRKHS 300 NLITVPIQDD 310 SNSGAREPPP 320 PAPAPAHHHP 330 EYQGQPVVSH 340 PHHIMPPQQH 350 YAPPPPPPPP 360 ISHPMPHPPQ 370 AAGTPHLVYS 380 QAPPPPMTSA 390 PPPITPPPGH 400 IIAQMPPYMN 410 HPPPGPPPPQ 420 HGGPPVTAPP 430 PHHYNPNSLP 440 QFTEDQGTLS 450 PPFTQPGGMS 460 PGIWPAPRGP 470 PPPPRLQGPP 480 SQTPLPGPHH 490 PDQTRYRPYY Q

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016607 nuclear speck
Cellular Component GO:0005634 nucleus
Cellular Component GO:0036396 RNA N6-methyladenosine methyltransferase complex
Cellular Component GO:0000151 ubiquitin ligase complex
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0061630 ubiquitin protein ligase activity
Molecular Function GO:0004842 ubiquitin-protein transferase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0098609 cell-cell adhesion
Biological Process GO:0006397 mRNA processing
Biological Process GO:0007162 negative regulation of cell adhesion
Biological Process GO:0030335 positive regulation of cell migration
Biological Process GO:0045807 positive regulation of endocytosis
Biological Process GO:0016567 protein ubiquitination
Biological Process GO:0030155 regulation of cell adhesion

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.