Search Results
Overview
| Uniprot ID | Q75WM6 |
|---|---|
| Protein Name | Testis-specific H1 histone |
| Gene Name | H1-7 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 105 | EAPRGQAKATLLRVS |
| 124 | AGYFRVWKVPKPRRK |
| 197 | RRARPRAKEPPCARA |
| 205 | EPPCARAKEEAGATA |
| 72 | LQAISTHKGLTLAAL |
Function
Essential for normal spermatogenesis and male fertility (PubMed:16533358). Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Involved in the histone-protamine transition of sperm chromatin and the subsequent production of functional sperm. Binds both double-stranded and single-stranded DNA, ATP and protamine-1
Protein Sequence
10
MEQALTGEAQ
20
SRWPRRGGSG
30
AMAEAPGPSG
40
ESRGHSATQL
50
PAEKTVGGPS
60
RGCSSSVLRV
70
SQLVLQAIST
80
HKGLTLAALK
90
KELRNAGYEV
100
RRKSGRHEAP
110
RGQAKATLLR
120
VSGSDAAGYF
130
RVWKVPKPRR
140
KPGRARQEEG
150
TRAPWRTPAA
160
PRSSRRRRQP
170
LRKAARKARE
180
VWRRNARAKA
190
KANARARRTR
200
RARPRAKEPP
210
CARAKEEAGA
220
TAADEGRGQA
230
VKEDTTPRSG
240
KDKRRSSKPR
250
EEKQEPKKPA
QRTIQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0003690 | double-stranded DNA binding |
| Molecular Function | GO:0031492 | nucleosomal DNA binding |
| Biological Process | GO:0030261 | chromosome condensation |
| Biological Process | GO:0045910 | negative regulation of DNA recombination |
| Biological Process | GO:0035092 | sperm DNA condensation |
| Biological Process | GO:0007290 | spermatid nucleus elongation |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.