Search Results

Overview

Uniprot IDQ76FK4
Protein NameNucleolar protein 8
Gene NameNOL8
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1070 VETVKPGKIVWQEDP
145 HKNWVVSKFGRVLPV
156 VLPVLHLKNQHKRKI
266 CDSITPSKSSPVPVS
279 VSDTQKLKNLPFKTS
284 KLKNLPFKTSGLETA
292 TSGLETAKKRNSISD
293 SGLETAKKRNSISDD
357 SLIGLGIKNRVSCHD
395 KKNVAKVKNSTEFSQ
426 ELSDHCIKLQKRKSN
443 SALSHGLKSLNRKSP
518 PETTTQCKFDRGSKS
574 KPKFQAFKGVGCLYE
721 SSGLTSLKKSPKVSS
722 SGLTSLKKSPKVSSK

Function

Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells

Protein Sequence

10 MKVNRETKRL 20 YVGGLSQDIS 30 EADLQNQFSR 40 FGEVSDVEII 50 TRKDDQGNPQ 60 KVFAYINISV 70 AEADLKKCMS 80 VLNKTKWKGG 90 TLQIQLAKES 100 FLHRLAQERE 110 AAKAKKEEST 120 TGNANLLEKT 130 GGVDFHMKAV 140 PGTEVPGHKN 150 WVVSKFGRVL 160 PVLHLKNQHK 170 RKIIKYDPSK 180 YCHNLKKIGE 190 DFSNTIPISS 200 LTWELEGGND 210 PMSKKRRGEF 220 SDFHGPPKKI 230 IKVQKDESST 240 GSLAMSTRPR 250 RVIERPPLTQ 260 QQAAQKRTCD 270 SITPSKSSPV 280 PVSDTQKLKN 290 LPFKTSGLET 300 AKKRNSISDD 310 DTDSEDELRM 320 MIAKEENLQR 330 TTQPSINESE 340 SDPFEVVRDD 350 FKSGVHKLHS 360 LIGLGIKNRV 370 SCHDSDDDIM 380 RNDREYDSGD 390 TDEIIAMKKN 400 VAKVKNSTEF 410 SQMEKSTKKT 420 SFKNRENCEL 430 SDHCIKLQKR 440 KSNVESALSH 450 GLKSLNRKSP 460 SHSSSSEDAD 470 SASELADSEG 480 GEEYNAMMKN 490 CLRVNLTLAD 500 LEQLAGSDLK 510 VPNEDTKSDG 520 PETTTQCKFD 530 RGSKSPKTPT 540 GLRRGRQCIR 550 PAEIVASLLE 560 GEENTCGKQK 570 PKENNLKPKF 580 QAFKGVGCLY 590 EKESMKKSLK 600 DSVASNNKDQ 610 NSMKHEDPSI 620 ISMEDGSPYV 630 NGSLGEVTPC 640 QHAKKANGPN 650 YIQPQKRQTT 660 FESQDRKAVS 670 PSSSEKRSKN 680 PISRPLEGKK 690 SLSLSAKTHN 700 IGFDKDSCHS 710 TTKTEASQEE 720 RSDSSGLTSL 730 KKSPKVSSKD 740 TREIKTDFSL 750 SISNSSDVSA 760 KDKHAEDNEK 770 RLAALEARQK 780 AKEVQKKLVH 790 NALANLDGHP 800 EDKPTHIIFG 810 SDSECETEET 820 STQEQSHPGE 830 EWVKESMGKT 840 SGKLFDSSDD 850 DESDSEDDSN 860 RFKIKPQFEG 870 RAGQKLMDLQ 880 SHFGTDDRFR 890 MDSRFLETDS 900 EEEQEEVNEK 910 KTAEEEELAE 920 EKKKALNVVQ 930 SVLQINLSNS 940 TNRGSVAAKK 950 FKDIIHYDPT 960 KQDHATYERK 970 RDDKPKESKA 980 KRKKKREEAE 990 KLPEVSKEMY 1000 YNIAMDLKEI 1010 FQTTKYTSEK 1020 EEGTPWNEDC 1030 GKEKPEEIQD 1040 PAALTSDAEQ 1050 PSGFTFSFFD 1060 SDTKDIKEET 1070 YRVETVKPGK 1080 IVWQEDPRLQ 1090 DSSSEEEDVT 1100 EETDHRNSSP 1110 GEASLLEKET 1120 TRFFFFSKND 1130 ERLQGSDLFW 1140 RGVGSNMSRN 1150 SWEARTTNLR 1160 MDCRKKHKDA KRKMKPK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005730 nucleolus
Molecular Function GO:0003723 RNA binding
Biological Process GO:1902570 protein localization to nucleolus
Biological Process GO:0006364 rRNA processing

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.