Search Results

Overview

Uniprot ID	Q78J03
Protein Name	Methionine-R-sulfoxide reductase B2, mitochondrial
Gene Name	Msrb2
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
50	SEADWQKKLTPEQFY

Function

Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance

Protein Sequence

10 MARLLRALRG 20 LPLLQAPGRL 30 ARGCAGSGSK 40 DTGSLTKSKR 50 SLSEADWQKK 60 LTPEQFYVTR 70 EKGTEAPFSG 80 MYLNNKETGM 90 YHCVCCDSPL 100 FSSEKKYCSG 110 TGWPSFSEAY 120 GSKGSDESHT 130 GILRRLDTSL 140 GCPRMEVVCK 150 QCEAHLGHVF 160 PDGPKPTGQR 170 FCINSVALKF KPSKP

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0003779	actin binding
Molecular Function	GO:0033745	L-methionine (R)-S-oxide reductase activity
Molecular Function	GO:0033743	peptide-methionine (R)-S-oxide reductase activity
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0030041	actin filament polymerization
Biological Process	GO:0030091	protein repair
Biological Process	GO:0006979	response to oxidative stress

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.