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Overview

Uniprot IDQ7KZF4
Protein NameStaphylococcal nuclease domain-containing protein 1
Gene NameSND1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
193 FVDSHHQKPVNAIIE
339 PTANLDQKDKQFVAK
341 ANLDQKDKQFVAKVM
414 RKKLIGKKVNVTVDY
497 GKGLHSKKEVPIHRV
513 DISGDTQKAKQFLPF
515 SGDTQKAKQFLPFLQ
541 VFSGSRLKLYLPKET
641 AERSSYYKSLLSAEE
651 LSAEEAAKQKKEKVW
653 AEEAAKQKKEKVWAH
886 LNAQESAKSARLNLW
93 LRKKLIGKEVCFTIE

Function

Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (PubMed:18453631, PubMed:28546213). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (PubMed:28546213). Functions as a bridging factor between STAT6 and the basal transcription factor (PubMed:12234934). Plays a role in PIM1 regulation of MYB activity (PubMed:9809063). Functions as a transcriptional coactivator for STAT5 (By similarity)

Protein Sequence

10 MASSAQSGGS 20 SGGPAVPTVQ 30 RGIIKMVLSG 40 CAIIVRGQPR 50 GGPPPERQIN 60 LSNIRAGNLA 70 RRAAATQPDA 80 KDTPDEPWAF 90 PAREFLRKKL 100 IGKEVCFTIE 110 NKTPQGREYG 120 MIYLGKDTNG 130 ENIAESLVAE 140 GLATRREGMR 150 ANNPEQNRLS 160 ECEEQAKAAK 170 KGMWSEGNGS 180 HTIRDLKYTI 190 ENPRHFVDSH 200 HQKPVNAIIE 210 HVRDGSVVRA 220 LLLPDYYLVT 230 VMLSGIKCPT 240 FRREADGSET 250 PEPFAAEAKF 260 FTESRLLQRD 270 VQIILESCHN 280 QNILGTILHP 290 NGNITELLLK 300 EGFARCVDWS 310 IAVYTRGAEK 320 LRAAERFAKE 330 RRLRIWRDYV 340 APTANLDQKD 350 KQFVAKVMQV 360 LNADAIVVKL 370 NSGDYKTIHL 380 SSIRPPRLEG 390 ENTQDKNKKL 400 RPLYDIPYMF 410 EAREFLRKKL 420 IGKKVNVTVD 430 YIRPASPATE 440 TVPAFSERTC 450 ATVTIGGINI 460 AEALVSKGLA 470 TVIRYRQDDD 480 QRSSHYDELL 490 AAEARAIKNG 500 KGLHSKKEVP 510 IHRVADISGD 520 TQKAKQFLPF 530 LQRAGRSEAV 540 VEYVFSGSRL 550 KLYLPKETCL 560 ITFLLAGIEC 570 PRGARNLPGL 580 VQEGEPFSEE 590 ATLFTKELVL 600 QREVEVEVES 610 MDKAGNFIGW 620 LHIDGANLSV 630 LLVEHALSKV 640 HFTAERSSYY 650 KSLLSAEEAA 660 KQKKEKVWAH 670 YEEQPVEEVM 680 PVLEEKERSA 690 SYKPVFVTEI 700 TDDLHFYVQD 710 VETGTQLEKL 720 MENMRNDIAS 730 HPPVEGSYAP 740 RRGEFCIAKF 750 VDGEWYRARV 760 EKVESPAKIH 770 VFYIDYGNRE 780 VLPSTRLGTL 790 SPAFSTRVLP 800 AQATEYAFAF 810 IQVPQDDDAR 820 TDAVDSVVRD 830 IQNTQCLLNV 840 EHLSAGCPHV 850 TLQFADSKGD 860 VGLGLVKEGL 870 VMVEVRKEKQ 880 FQKVITEYLN 890 AQESAKSARL 900 NLWRYGDFRA 910 DDADEFGYSR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0097433 dense body
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0042470 melanosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0005634 nucleus
Cellular Component GO:0031332 RNAi effector complex
Molecular Function GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0004519 endonuclease activity
Molecular Function GO:1905172 RISC complex binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0004521 RNA endonuclease activity
Molecular Function GO:0003712 transcription coregulator activity
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0010587 miRNA catabolic process
Biological Process GO:0006402 mRNA catabolic process
Biological Process GO:0001649 osteoblast differentiation
Biological Process GO:0010564 regulation of cell cycle process
Biological Process GO:0031047 regulatory ncRNA-mediated gene silencing

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.