Search Results

Overview

Uniprot IDQ7L1Q6
Protein NameeIF5-mimic protein 2
Gene NameBZW1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
272 MSRGDPFKDIILYVK
390 DAHVAKGKSVFLEQM
5 ***MNNQKQQKPTLS
60 FLDASGAKLDYRRYA
8 MNNQKQQKPTLSGQR

Function

Translation initiation regulator which represses repeat-associated non-AUG (RAN) initiated translation probably by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (PubMed:29470543, PubMed:34260931). Enhances histone H4 gene transcription but does not seem to bind DNA directly (PubMed:11524015)

Protein Sequence

10 MNNQKQQKPT 20 LSGQRFKTRK 30 RDEKERFDPT 40 QFQDCIIQGL 50 TETGTDLEAV 60 AKFLDASGAK 70 LDYRRYAETL 80 FDILVAGGML 90 APGGTLADDM 100 MRTDVCVFAA 110 QEDLETMQAF 120 AQVFNKLIRR 130 YKYLEKGFED 140 EVKKLLLFLK 150 GFSESERNKL 160 AMLTGVLLAN 170 GTLNASILNS 180 LYNENLVKEG 190 VSAAFAVKLF 200 KSWINEKDIN 210 AVAASLRKVS 220 MDNRLMELFP 230 ANKQSVEHFT 240 KYFTEAGLKE 250 LSEYVRNQQT 260 IGARKELQKE 270 LQEQMSRGDP 280 FKDIILYVKE 290 EMKKNNIPEP 300 VVIGIVWSSV 310 MSTVEWNKKE 320 ELVAEQAIKH 330 LKQYSPLLAA 340 FTTQGQSELT 350 LLLKIQEYCY 360 DNIHFMKAFQ 370 KIVVLFYKAE 380 VLSEEPILKW 390 YKDAHVAKGK 400 SVFLEQMKKF 410 VEWLKNAEEE SESEAEEGD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0016020 membrane
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0006446 regulation of translational initiation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.