Overview
| Uniprot ID | Q7L2H7 |
|---|
| Protein Name | Eukaryotic translation initiation factor 3 subunit M |
|---|
| Gene Name | EIF3M |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 176 |
YEALVDCKKSDAASK |
| 177 |
EALVDCKKSDAASKV |
Function
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17403899, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17403899). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773)
Protein Sequence
10
MSVPAFIDIS
20
EEDQAAELRA
30
YLKSKGAEIS
40
EENSEGGLHV
50
DLAQIIEACD
60
VCLKEDDKDV
70
ESVMNSVVSL
80
LLILEPDKQE
90
ALIESLCEKL
100
VKFREGERPS
110
LRLQLLSNLF
120
HGMDKNTPVR
130
YTVYCSLIKV
140
AASCGAIQYI
150
PTELDQVRKW
160
ISDWNLTTEK
170
KHTLLRLLYE
180
ALVDCKKSDA
190
ASKVMVELLG
200
SYTEDNASQA
210
RVDAHRCIVR
220
ALKDPNAFLF
230
DHLLTLKPVK
240
FLEGELIHDL
250
LTIFVSAKLA
260
SYVKFYQNNK
270
DFIDSLGLLH
280
EQNMAKMRLL
290
TFMGMAVENK
300
EISFDTMQQE
310
LQIGADDVEA
320
FVIDAVRTKM
330
VYCKIDQTQR
340
KVVVSHSTHR
350
TFGKQQWQQL
360
YDTLNAWKQN
370
LNKVKNSLLS
LSDT
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0016282 |
eukaryotic 43S preinitiation complex |
| Cellular Component |
GO:0033290 |
eukaryotic 48S preinitiation complex |
| Cellular Component |
GO:0005852 |
eukaryotic translation initiation factor 3 complex |
| Cellular Component |
GO:0071541 |
eukaryotic translation initiation factor 3 complex, eIF3m |
| Molecular Function |
GO:0003743 |
translation initiation factor activity |
| Molecular Function |
GO:0031369 |
translation initiation factor binding |
| Biological Process |
GO:0002183 |
cytoplasmic translational initiation |
| Biological Process |
GO:0001732 |
formation of cytoplasmic translation initiation complex |
| Biological Process |
GO:0006413 |
translational initiation |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.