Overview
| Uniprot ID | Q7L2Z9 |
|---|
| Protein Name | Centromere protein Q |
|---|
| Gene Name | CENPQ |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 10 |
GKANASKKNAQQLKR |
Function
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (PubMed:16622420). Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores (PubMed:25395579)
Protein Sequence
10
MSGKANASKK
20
NAQQLKRNPK
30
RKKDNEEVVL
40
SENKVRNTVK
50
KNKNHLKDLS
60
SEGQTKHTNL
70
KHGKTAASKR
80
KTWQPLSKST
90
RDHLQTMMES
100
VIMTILSNSI
110
KEKEEIQYHL
120
NFLKKRLLQQ
130
CETLKVPPKK
140
MEDLTNVSSL
150
LNMERARDKA
160
NEEGLALLQE
170
EIDKMVETTE
180
LMTGNIQSLK
190
NKIQILASEV
200
EEEEERVKQM
210
HQINSSGVLS
220
LPELSQKTLK
230
APTLQKEILA
240
LIPNQNALLK
250
DLDILHNSSQ
260
MKSMSTFIEE
AYKKLDAS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0000939 |
inner kinetochore |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Biological Process |
GO:0007059 |
chromosome segregation |
| Biological Process |
GO:0051310 |
metaphase chromosome alignment |
| Biological Process |
GO:1905342 |
positive regulation of protein localization to kinetochore |
Reference
[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.