Search Results
Overview
| Uniprot ID | Q7L590 |
|---|---|
| Protein Name | Protein MCM10 homolog |
| Gene Name | MCM10 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 665 | KKLAAITKLRAKGQV |
| 675 | AKGQVLTKTNPNSIK |
Function
Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (PubMed:24726359)
Protein Sequence
10
MDEEEDNLSL
20
LTALLEENES
30
ALDCNSEENN
40
FLTRENGEPD
50
AFDELFDADG
60
DGESYTEEAD
70
DGETGETRDE
80
KENLATLFGD
90
MEDLTDEEEV
100
PASQSTENRV
110
LPAPAPRREK
120
TNEELQEELR
130
NLQEQMKALQ
140
EQLKVTTIKQ
150
TASPARLQKS
160
PVEKSPRPPL
170
KERRVQRIQE
180
STCFSAELDV
190
PALPRTKRVA
200
RTPKASPPDP
210
KSSSSRMTSA
220
PSQPLQTISR
230
NKPSGITRGQ
240
IVGTPGSSGE
250
TTQPICVEAF
260
SGLRLRRPRV
270
SSTEMNKKMT
280
GRKLIRLSQI
290
KEKMAREKLE
300
EIDWVTFGVI
310
LKKVTPQSVN
320
SGKTFSIWKL
330
NDLRDLTQCV
340
SLFLFGEVHK
350
ALWKTEQGTV
360
VGILNANPMK
370
PKDGSEEVCL
380
SIDHPQKVLI
390
MGEALDLGTC
400
KAKKKNGEPC
410
TQTVNLRDCE
420
YCQYHVQAQY
430
KKLSAKRADL
440
QSTFSGGRIP
450
KKFARRGTSL
460
KERLCQDGFY
470
YGGVSSASYA
480
ASIAAAVAPK
490
KKIQTTLSNL
500
VVKGTNLIIQ
510
ETRQKLGIPQ
520
KSLSCSEEFK
530
ELMDLPTCGA
540
RNLKQHLAKA
550
TASGIMGSPK
560
PAIKSISASA
570
LLKQQKQRML
580
EMRRRKSEEI
590
QKRFLQSSSE
600
VESPAVPSSS
610
RQPPAQPPRT
620
GSEFPRLEGA
630
PATMTPKLGR
640
GVLEGDDVLF
650
YDESPPPRPK
660
LSALAEAKKL
670
AAITKLRAKG
680
QVLTKTNPNS
690
IKKKQKDPQD
700
ILEVKERVEK
710
NTMFSSQAED
720
ELEPARKKRR
730
EQLAYLESEE
740
FQKILKAKSK
750
HTGILKEAEA
760
EMQERYFEPL
770
VKKEQMEEKM
780
RNIREVKCRV
790
VTCKTCAYTH
800
FKLLETCVSE
810
QHEYHWHDGV
820
KRFFKCPCGN
830
RSISLDRLPN
840
KHCSNCGLYK
850
WERDGMLKEK
860
TGPKIGGETL
870
LPRGEEHAKF
LNSLK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0043596 | nuclear replication fork |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003688 | DNA replication origin binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0003697 | single-stranded DNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006974 | DNA damage response |
| Biological Process | GO:0006270 | DNA replication initiation |
Reference
PMID: N/A