Overview
| Uniprot ID | Q7L5N7 |
|---|
| Protein Name | Lysophosphatidylcholine acyltransferase 2 |
|---|
| Gene Name | LPCAT2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 233 |
RSCLITFKPGAFIPG |
Function
Exhibits both acyltransferase and acetyltransferase activities (PubMed:17182612, PubMed:20363836, PubMed:21498505). Catalyzes the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:21498505). Catalyzes the conversion 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:20363836). Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) (PubMed:17182612). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor (By similarity). Under resting conditions, acyltransferase activity is preferred (By similarity). Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases (By similarity). Involved in the regulation of lipid droplet number and size (PubMed:25491198)
Protein Sequence
10
MSRCAQAAEV
20
AATVPGAGVG
30
NVGLRPPMVP
40
RQASFFPPPV
50
PNPFVQQTQI
60
GSARRVQIVL
70
LGIILLPIRV
80
LLVALILLLA
90
WPFAAISTVC
100
CPEKLTHPIT
110
GWRRKITQTA
120
LKFLGRAMFF
130
SMGFIVAVKG
140
KIASPLEAPV
150
FVAAPHSTFF
160
DGIACVVAGL
170
PSMVSRNENA
180
QVPLIGRLLR
190
AVQPVLVSRV
200
DPDSRKNTIN
210
EIIKRTTSGG
220
EWPQILVFPE
230
GTCTNRSCLI
240
TFKPGAFIPG
250
VPVQPVLLRY
260
PNKLDTVTWT
270
WQGYTFIQLC
280
MLTFCQLFTK
290
VEVEFMPVQV
300
PNDEEKNDPV
310
LFANKVRNLM
320
AEALGIPVTD
330
HTYEDCRLMI
340
SAGQLTLPME
350
AGLVEFTKIS
360
RKLKLDWDGV
370
RKHLDEYASI
380
ASSSKGGRIG
390
IEEFAKYLKL
400
PVSDVLRQLF
410
ALFDRNHDGS
420
IDFREYVIGL
430
AVLCNPSNTE
440
EIIQVAFKLF
450
DVDEDGYITE
460
EEFSTILQAS
470
LGVPDLDVSG
480
LFKEIAQGDS
490
ISYEEFKSFA
500
LKHPEYAKIF
510
TTYLDLQTCH
520
VFSLPKEVQT
530
TPSTASNKVS
540
PEKHEESTSD
KKDD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Biological Process |
GO:0006663 |
platelet activating factor biosynthetic process |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Cellular Component |
GO:0005795 |
Golgi stack |
| Cellular Component |
GO:0005811 |
lipid droplet |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0003841 |
1-acylglycerol-3-phosphate O-acyltransferase activity |
| Molecular Function |
GO:0047184 |
1-acylglycerophosphocholine O-acyltransferase activity |
| Molecular Function |
GO:0047192 |
1-alkylglycerophosphocholine O-acetyltransferase activity |
| Molecular Function |
GO:0047144 |
2-acylglycerol-3-phosphate O-acyltransferase activity |
| Molecular Function |
GO:0005509 |
calcium ion binding |
| Molecular Function |
GO:0042171 |
lysophosphatidic acid acyltransferase activity |
| Molecular Function |
GO:0047159 |
plasmalogen synthase activity |
| Biological Process |
GO:0061024 |
membrane organization |
| Biological Process |
GO:0036151 |
phosphatidylcholine acyl-chain remodeling |
Reference
PMID: N/A