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Overview

Uniprot ID	Q7L9L4
Protein Name	MOB kinase activator 1B
Gene Name	MOB1B
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
104	WADGTNIKKPIKCSA
17	SKTFKPKKNIPEGSH

Function

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L

Protein Sequence

10 MSFLFGSRSS 20 KTFKPKKNIP 30 EGSHQYELLK 40 HAEATLGSGN 50 LRMAVMLPEG 60 EDLNEWVAVN 70 TVDFFNQINM 80 LYGTITDFCT 90 EESCPVMSAG 100 PKYEYHWADG 110 TNIKKPIKCS 120 APKYIDYLMT 130 WVQDQLDDET 140 LFPSKIGVPF 150 PKNFMSVAKT 160 ILKRLFRVYA 170 HIYHQHFDPV 180 IQLQEEAHLN 190 TSFKHFIFFV 200 QEFNLIDRRE 210 LAPLQELIEK LTSKDR

Gene Ontology

Classification	GO ID	Description
Biological Process	GO:0031952	regulation of protein autophosphorylation
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0019209	kinase activator activity
Molecular Function	GO:0019900	kinase binding
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0030295	protein kinase activator activity
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity
Biological Process	GO:0035329	hippo signaling

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.