Search Results
Overview
| Uniprot ID | Q7M2W6 |
|---|---|
| Protein Name | Alpha-crystallin B chain |
| Gene Name | CRYAB |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 92 | SPEELKVKVLGDVIE |
Function
May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome (By similarity)
Protein Sequence
10
MDIAIHHPWI
20
RRPFFPFHSP
30
SRLFDQFFGE
40
HLLESDLFPA
50
STSLSPFYFR
60
PPSFLRAPSW
70
IDTGLSEMRL
80
EKDRFSVNLD
90
VKHFSPEELK
100
VKVLGDVIEV
110
HGKHEERQDE
120
HGFISREFHR
130
KYRIPADVDP
140
LTITSSLSSD
150
GVLTVNGPRR
160
QASGPERTIP
170
ITREEKPAVT
AAPKK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0005212 | structural constituent of eye lens |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0042026 | protein refolding |
| Biological Process | GO:0009408 | response to heat |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.