Search Results
Overview
| Uniprot ID | Q7TMB8 |
|---|---|
| Protein Name | Cytoplasmic FMR1-interacting protein 1 |
| Gene Name | Cyfip1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1210 | KMVERIRKFQILNDE |
Function
Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (PubMed:27605705)
Protein Sequence
10
MAAQVTLEDA
20
LSNVDLLEEL
30
PLPDQQPCIE
40
PPPSSLLYQP
50
NFNTNFEDRN
60
AFVTGIARYI
70
EQATVHSSMN
80
EMLEEGQEYA
90
VMLYTWRSCS
100
RAIPQVKCNE
110
QPNRVEIYEK
120
TVEVLEPEVT
130
KLMNFMYFQR
140
NAIERFCGEV
150
RRLCHAERRK
160
DFVSEAYLIT
170
LGKFINMFAV
180
LDELKNMKCS
190
VKNDHSAYKR
200
AAQFLRKMAD
210
PQSIQESQNL
220
SMFLANHNKI
230
TQSLQQQLEV
240
ISGYEELLAD
250
IVNLCVDYYE
260
NRMYLTPSEK
270
HMLLKVMGFG
280
LYLMDGSVSN
290
IYKLDAKKRI
300
NLSKIDKYFK
310
QLQVVPLFGD
320
MQIELARYIK
330
TSAHYEENKS
340
RWTCASSSSS
350
PQYNICEQMI
360
QIREDHMRFI
370
SELARYSNSE
380
VVTGSGRQEA
390
QKTDAEYRKL
400
FDLALQGLQL
410
LSQWSAHVME
420
VYSWKLVHPT
430
DKYSNKDCPD
440
NAEEYERATR
450
YNYTTEEKFA
460
LVEVIAMIKG
470
LQVLMGRMES
480
VFNHAIRHTV
490
YAALQDFSQV
500
TLREPLRQAI
510
KKKKNVIQSV
520
LQAIRKTVCD
530
WETGHEPFND
540
PALRGEKDPK
550
SGFDIKVPRR
560
AVGPSSTQLY
570
MVRTMLESLI
580
ADKSGSKKTL
590
RSSLEGPTIL
600
DIEKFHRESF
610
FYTHLINFSE
620
TLQQCCDLSQ
630
LWFREFFLEL
640
TMGRRIQFPI
650
EMSMPWILTD
660
HILETKEASM
670
MEYVLYSLDL
680
YNDSAHYALT
690
KFNKQFLYDE
700
IEAEVNLCFD
710
QFVYKLADQI
720
FAYYKVMAGS
730
LLLDKRLRSE
740
CKNQGATIHL
750
PPSNRYETLL
760
KQRHVQLLGR
770
SIDLNRLITQ
780
RVSAAMYKSL
790
ELAIGRFESE
800
DLTSVVELDG
810
LLEINRMTHK
820
LLSRYLTLDS
830
FDAMFREANH
840
NVSAPYGRIT
850
LHVFWELNYD
860
FLPNYCYNGS
870
TNRFVRTVLP
880
FSQEFQRDKQ
890
PNAQPQYLHG
900
SKALNLAYSS
910
IYGSYRNFVG
920
PPHFQVICRL
930
LGYQGIAVVM
940
EELLKVVKSL
950
LQGTILQYVK
960
TLMEVMPKIC
970
RLPRHEYGSP
980
GILEFFHHQL
990
KDIVEYAELK
1000
TVCFQNLREV
1010
GNAVLFCLLI
1020
EQSLSLEEVC
1030
DLLHAAPFQN
1040
ILPRIHVKEG
1050
ERVDAKMKRL
1060
ESKYAPLHLV
1070
PLIERLGTPQ
1080
QIAIAREGDL
1090
LTKERLCCGL
1100
SMFEVILTRI
1110
RTFLDDPIWR
1120
GPLPSNGVMH
1130
VDECVEFHRL
1140
WSAMQFVYCI
1150
PVGTHEFTVE
1160
QCFGDGLHWA
1170
GCMIIVLLGQ
1180
QRRFAVLDFC
1190
YHLLKVQKHD
1200
GKDEIIKNVP
1210
LKKMVERIRK
1220
FQILNDEIIT
1230
ILDKYLKSGD
1240
GESTPVEHVR
1250
CFQPPIHQSL
ASS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0044295 | axonal growth cone |
| Cellular Component | GO:0031252 | cell leading edge |
| Cellular Component | GO:0090724 | central region of growth cone |
| Cellular Component | GO:0044294 | dendritic growth cone |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0060076 | excitatory synapse |
| Cellular Component | GO:0032433 | filopodium tip |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0090725 | peripheral region of growth cone |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0001726 | ruffle |
| Cellular Component | GO:0031209 | SCAR complex |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0043195 | terminal bouton |
| Cellular Component | GO:1903502 | translation repressor complex |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0005522 | profilin binding |
| Molecular Function | GO:0000340 | RNA 7-methylguanosine cap binding |
| Molecular Function | GO:0031267 | small GTPase binding |
| Molecular Function | GO:0030371 | translation repressor activity |
| Biological Process | GO:0048675 | axon extension |
| Biological Process | GO:0007411 | axon guidance |
| Biological Process | GO:0000902 | cell morphogenesis |
| Biological Process | GO:0032869 | cellular response to insulin stimulus |
| Biological Process | GO:0050890 | cognition |
| Biological Process | GO:0097484 | dendrite extension |
| Biological Process | GO:0030032 | lamellipodium assembly |
| Biological Process | GO:1903422 | negative regulation of synaptic vesicle recycling |
| Biological Process | GO:0031175 | neuron projection development |
| Biological Process | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation |
| Biological Process | GO:0045773 | positive regulation of axon extension |
| Biological Process | GO:0050772 | positive regulation of axonogenesis |
| Biological Process | GO:1900006 | positive regulation of dendrite development |
| Biological Process | GO:0010592 | positive regulation of lamellipodium assembly |
| Biological Process | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway |
| Biological Process | GO:1900029 | positive regulation of ruffle assembly |
| Biological Process | GO:0016601 | Rac protein signal transduction |
| Biological Process | GO:0030833 | regulation of actin filament polymerization |
| Biological Process | GO:0008360 | regulation of cell shape |
| Biological Process | GO:1905274 | regulation of modification of postsynaptic actin cytoskeleton |
| Biological Process | GO:0031641 | regulation of myelination |
| Biological Process | GO:0006417 | regulation of translation |
| Biological Process | GO:0099578 | regulation of translation at postsynapse, modulating synaptic transmission |
| Biological Process | GO:0051602 | response to electrical stimulus |
| Biological Process | GO:0031529 | ruffle organization |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.