Search Results
Overview
| Uniprot ID | Q7TMF3 |
|---|---|
| Protein Name | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 |
| Gene Name | Ndufa12 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 107 | TNPPTARKFIWTNHK |
| 43 | GTLVGEDKYGNKYYE |
| 47 | GEDKYGNKYYEDNKQ |
| 53 | NKYYEDNKQFFGRHR |
| 8 | MELVEVLKRGVQQVT |
Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Protein Sequence
10
MELVEVLKRG
20
VQQVTGHGGL
30
RGLLRVFFRA
40
NDIRIGTLVG
50
EDKYGNKYYE
60
DNKQFFGRHR
70
WVIYTTEMNG
80
KNTFWDVDGS
90
MVPPEWHRWL
100
HCMTDDPPTT
110
NPPTARKFIW
120
TNHKFNVSAT
130
PEQYVPYSTT
140
RKKIHEWVPP
STPYK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0045271 | respiratory chain complex I |
| Biological Process | GO:0009060 | aerobic respiration |
| Biological Process | GO:0042775 | mitochondrial ATP synthesis coupled electron transport |
| Biological Process | GO:0042776 | proton motive force-driven mitochondrial ATP synthesis |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.