Search Results
Overview
| Uniprot ID | Q7TMR0 |
|---|---|
| Protein Name | Lysosomal Pro-X carboxypeptidase |
| Gene Name | Prcp |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 226 | IVTNDFRKSGPYCSE |
Function
Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH (By similarity)
Protein Sequence
10
MGCRALLLLS
20
FLLLGAATTI
30
PPRLKTLGSP
40
HLSASPTPDP
50
AVARKYSVLY
60
FEQKVDHFGF
70
ADMRTFKQRY
80
LVADKHWQRN
90
GGSILFYTGN
100
EGDIVWFCNN
110
TGFMWDVAEE
120
LKAMLVFAEH
130
RYYGESLPFG
140
QDSFKDSQHL
150
NFLTSEQALA
160
DFAELIRHLE
170
KTIPGAQGQP
180
VIAIGGSYGG
190
MLAAWFRMKY
200
PHIVVGALAA
210
SAPIWQLDGM
220
VPCGEFMKIV
230
TNDFRKSGPY
240
CSESIRKSWN
250
VIDKLSGSGS
260
GLQSLTNILH
270
LCSPLTSEKI
280
PTLKGWIAET
290
WVNLAMVNYP
300
YACNFLQPLP
310
AWPIKEVCQY
320
LKNPNVSDTV
330
LLQNIFQALS
340
VYYNYSGQAA
350
CLNISQTTTS
360
SLGSMGWSFQ
370
ACTEMVMPFC
380
TNGIDDMFEP
390
FLWDLEKYSN
400
DCFNQWGVKP
410
RPHWMTTMYG
420
GKNISSHSNI
430
IFSNGELDPW
440
SGGGVTRDIT
450
DTLVAINIHD
460
GAHHLDLRAH
470
NAFDPSSVLL
480
SRLLEVKHMK
490
KWILDFYSNI
Q
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0045178 | basal part of cell |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005764 | lysosome |
| Molecular Function | GO:0008239 | dipeptidyl-peptidase activity |
| Molecular Function | GO:0004181 | metallocarboxypeptidase activity |
| Molecular Function | GO:0004185 | serine-type carboxypeptidase activity |
| Biological Process | GO:0060055 | angiogenesis involved in wound healing |
| Biological Process | GO:0002003 | angiotensin maturation |
| Biological Process | GO:0097009 | energy homeostasis |
| Biological Process | GO:0042593 | glucose homeostasis |
| Biological Process | GO:0003085 | negative regulation of systemic arterial blood pressure |
| Biological Process | GO:0002353 | plasma kallikrein-kinin cascade |
| Biological Process | GO:0043535 | regulation of blood vessel endothelial cell migration |
| Biological Process | GO:2000377 | regulation of reactive oxygen species metabolic process |
| Biological Process | GO:0002155 | regulation of thyroid hormone receptor signaling pathway |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.