Overview
| Uniprot ID | Q7TQD2 |
|---|
| Protein Name | Tubulin polymerization-promoting protein |
|---|
| Gene Name | Tppp |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 170 |
SRLTDTSKFTGSHKE |
Function
Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (PubMed:31522887). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath (PubMed:31522887). Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes (PubMed:31522887). Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear (By similarity). In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network (PubMed:18028908). Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 (By similarity). Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility (By similarity). Plays a role in cell proliferation by regulating the G1/S-phase transition (By similarity). Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 (By similarity)
Protein Sequence
10
MADSKAKPAK
20
AANKTPPKSP
30
GDPARAAKRL
40
SLESEGANEG
50
ATAAPELSAL
60
EEAFRRFAVH
70
GDTRATGKEM
80
HGKNWSKLCK
90
DCHVIDGKNV
100
TVTDVDIVFS
110
KIKGKSCRTI
120
TFEQFQEALE
130
ELAKKRFKDK
140
SSEEAVREVH
150
RLIEGRAPVI
160
SGVTKAVSSP
170
TVSRLTDTSK
180
FTGSHKERFD
190
QSGKGKGKAG
200
RVDLVDESGY
210
VPGYKHAGTY
DQKVQGGK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005874 |
microtubule |
| Cellular Component |
GO:0097427 |
microtubule bundle |
| Cellular Component |
GO:0005815 |
microtubule organizing center |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0072686 |
mitotic spindle |
| Cellular Component |
GO:0043209 |
myelin sheath |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0150051 |
postsynaptic Golgi apparatus |
| Molecular Function |
GO:0003924 |
GTPase activity |
| Molecular Function |
GO:0000287 |
magnesium ion binding |
| Molecular Function |
GO:0008017 |
microtubule binding |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Molecular Function |
GO:0015631 |
tubulin binding |
| Biological Process |
GO:0030953 |
astral microtubule organization |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0001578 |
microtubule bundle formation |
| Biological Process |
GO:0051418 |
microtubule nucleation by microtubule organizing center |
| Biological Process |
GO:0046785 |
microtubule polymerization |
| Biological Process |
GO:0032288 |
myelin assembly |
| Biological Process |
GO:1904428 |
negative regulation of tubulin deacetylation |
| Biological Process |
GO:0014003 |
oligodendrocyte development |
| Biological Process |
GO:0048709 |
oligodendrocyte differentiation |
| Biological Process |
GO:0031643 |
positive regulation of myelination |
| Biological Process |
GO:0032273 |
positive regulation of protein polymerization |
| Biological Process |
GO:0031334 |
positive regulation of protein-containing complex assembly |
| Biological Process |
GO:0070507 |
regulation of microtubule cytoskeleton organization |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.