Search Results

Overview

Uniprot ID	Q7TSH2
Protein Name	Phosphorylase b kinase regulatory subunit beta
Gene Name	Phkb
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
684	FEELEFPKHSKVKRQ

Function

Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation (By similarity)

Protein Sequence

10 MANSPDAAFS 20 SPALLRSGSV 30 YEPLKSINLP 40 RPDNETLWDK 50 LDHYYRIVKS 60 TMLMYQSPTT 70 GLFPTKTCGG 80 EEKSKVHESL 90 YCAAGAWALA 100 LAYRRIDDDK 110 GRTHELEHSA 120 IKCMRGILYC 130 YMRQADKVQQ 140 FKQDPRPTTC 150 LHSVFSVHTG 160 DELLSYEEYG 170 HLQINAVSLF 180 LLYLVEMISS 190 GLQIIYNTDE 200 VSFIQNLVFC 210 VERVYRVPDF 220 GVWERGSKYN 230 NGSTELHSSS 240 VGLAKAALEA 250 INGFNLFGNQ 260 GCSWSVIFVD 270 LDAHNRNRQT 280 LCSLLPRESR 290 SHNTDAALLP 300 CISYPAFALD 310 DEALFSQTLD 320 KVIRKLKGKY 330 GFKRFLRDGY 340 RTPLEDPNRR 350 YYKPAEIKLF 360 DGIECEFPIF 370 FLYMMIDGVF 380 RGNLEQVKEY 390 QDLLTPLLHQ 400 TTEGYPVVPK 410 YYYVPADFVE 420 CEKRNPGSQK 430 RFPSNCGRDG 440 KLFLWGQALY 450 IIAKLLADEL 460 ISPKDIDPVQ 470 RFVPLQNQRN 480 VSMRYSNQGP 490 LENDLVVHVA 500 LVAESQRLQV 510 FLNTYGIQTQ 520 TPQQVEPIQI 530 WPQQELVKAY 540 FHLGINEKLG 550 LSGRPDRPIG 560 CLGTSKIYRI 570 LGKTVVCYPI 580 IFDLSDFYMS 590 QDVLLLIDDI 600 KNALQFIKQY 610 WKMHGRPLFL 620 VLIREDNIRG 630 SRFNPILDML 640 AAFKKGIIGG 650 VKVHVDRLQT 660 LISGAVVEQL 670 DFLRISDTEK 680 LPEFKSFEEL 690 EFPKHSKVKR 700 QSSTADAPEA 710 QHEPGITITE 720 WKNKSTHEIL 730 QKLNDCGCLA 740 GQTILLGILL 750 KREGPNFITM 760 EGTVSDHIER 770 VYRRAGSKKL 780 WSVVRRAASL 790 LNKVVDSLAP 800 SITNVLVQGK 810 QVTLGAFGHE 820 EEVISNPLSP 830 RVIKNIIYYK 840 CNTHDEREAV 850 IQQELVIHIG 860 WIISNSPELF 870 SGMLKIRIGW 880 IIHAMEYELQ 890 VRGGDKPAVD 900 LYQLSPSEVK 910 QLLLDILQPQ 920 QSGRCWLNRR 930 QIDGSLNRTP 940 PEFYDRVWQI 950 LERTPNGIVV 960 AGKHLPQQPT 970 LSDMTMYEMN 980 FSLLVEDMLG 990 NIDQPKYRQI 1000 IVELLMVVSI 1010 VLERNPELEF 1020 QDKVDLDRLV 1030 KEAFHEFQKD 1040 ESRLKEIEKQ 1050 DDMTSFYNTP 1060 PLGKRGTCSY 1070 LTKVVMNSLL 1080 EGEVKPSNED SCLVS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005964	phosphorylase kinase complex
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0005516	calmodulin binding
Biological Process	GO:0042593	glucose homeostasis
Biological Process	GO:0005980	glycogen catabolic process
Biological Process	GO:0045819	positive regulation of glycogen catabolic process
Biological Process	GO:0006468	protein phosphorylation

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.