Overview
| Uniprot ID | Q7Z2E3 |
|---|
| Protein Name | Aprataxin |
|---|
| Gene Name | APTX |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 169 |
SVPLKKGKDAPIKKE |
| 175 |
GKDAPIKKESLGHWS |
Function
DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair (PubMed:15044383, PubMed:15380105, PubMed:16964241, PubMed:17276982, PubMed:24362567). Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species (PubMed:16964241, PubMed:24362567). Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined (PubMed:16964241, PubMed:17276982, PubMed:24362567). Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (PubMed:16547001). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity)
Protein Sequence
10
MSNVNLSVSD
20
FWRVMMRVCW
30
LVRQDSRHQR
40
IRLPHLEAVV
50
IGRGPETKIT
60
DKKCSRQQVQ
70
LKAECNKGYV
80
KVKQVGVNPT
90
SIDSVVIGKD
100
QEVKLQPGQV
110
LHMVNELYPY
120
IVEFEEEAKN
130
PGLETHRKRK
140
RSGNSDSIER
150
DAAQEAEAGT
160
GLEPGSNSGQ
170
CSVPLKKGKD
180
APIKKESLGH
190
WSQGLKISMQ
200
DPKMQVYKDE
210
QVVVIKDKYP
220
KARYHWLVLP
230
WTSISSLKAV
240
AREHLELLKH
250
MHTVGEKVIV
260
DFAGSSKLRF
270
RLGYHAIPSM
280
SHVHLHVISQ
290
DFDSPCLKNK
300
KHWNSFNTEY
310
FLESQAVIEM
320
VQEAGRVTVR
330
DGMPELLKLP
340
LRCHECQQLL
350
PSIPQLKEHL
RKHWTQ
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000785 |
chromatin |
| Molecular Function |
GO:0051219 |
phosphoprotein binding |
| Molecular Function |
GO:0046403 |
polynucleotide 3'-phosphatase activity |
| Molecular Function |
GO:1990165 |
single-strand break-containing DNA binding |
| Molecular Function |
GO:0003697 |
single-stranded DNA binding |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0006282 |
regulation of DNA repair |
| Biological Process |
GO:0031647 |
regulation of protein stability |
| Biological Process |
GO:0000012 |
single strand break repair |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0090734 |
site of DNA damage |
| Molecular Function |
GO:0003682 |
chromatin binding |
| Molecular Function |
GO:0003684 |
damaged DNA binding |
| Molecular Function |
GO:0033699 |
DNA 5'-adenosine monophosphate hydrolase activity |
| Molecular Function |
GO:0120108 |
DNA-3'-diphospho-5'-guanosine diphosphatase activity |
| Molecular Function |
GO:0003690 |
double-stranded DNA binding |
| Molecular Function |
GO:0003725 |
double-stranded RNA binding |
| Molecular Function |
GO:0030983 |
mismatched DNA binding |
| Molecular Function |
GO:0008967 |
phosphoglycolate phosphatase activity |
Reference
PMID: N/A