Search Results

Overview

Uniprot IDQ7Z2Z1
Protein NameTreslin
Gene NameTICRR
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1118 QKSLSFSKTTPRRIS
1283 RAEEPAQKLKDKAIK

Function

Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation

Protein Sequence

10 MACCHKVMLL 20 LDTAGGAARH 30 SRVRRAALRL 40 LTYLSCRFGL 50 ARVHWAFKFF 60 DSQGARSRPS 70 RVSDFRELGS 80 RSWEDFEEEL 90 EARLEDRAHL 100 PGPAPRATHT 110 HGALMETLLD 120 YQWDRPEITS 130 PTKPILRSSG 140 RRLLDVESEA 150 KEAEAALGGL 160 VNAVFLLAPC 170 PHSQRELLQF 180 VSGCEAQAQR 190 LPPTPKQVME 200 KLLPKRVREV 210 MVARKITFYW 220 VDTTEWSKLW 230 ESPDHLGYWT 240 VCELLHHGGG 250 TVLPSESFSW 260 DFAQAGEMLL 270 RSGIKLSSEP 280 HLSPWISMLP 290 TDATLNRLLY 300 NSPEYEASFP 310 RMEGMLFLPV 320 EAGKEIQETW 330 TVTLEPLAMH 340 QRHFQKPVRI 350 FLKGSVAQWS 360 LPTSSTLGTD 370 SWMLGSPEES 380 TATQRLLFQQ 390 LVSRLTAEEL 400 HLVADVDPGE 410 GRPPITGVIS 420 PLSASAMILT 430 VCRTKEAEFQ 440 RHVLQTAVAD 450 SPRDTASLFS 460 DVVDSILNQT 470 HDSLADTASA 480 ASPVPEWAQQ 490 ELGHTTPWSP 500 AVVEKWFPFC 510 NISGASSDLM 520 ESFGLLQAAS 530 ANKEESSKTE 540 GELIHCLAEL 550 YQRKSREEST 560 IAHQEDSKKK 570 RGVPRTPVRQ 580 KMNTMCRSLK 590 MLNVARLNVK 600 AQKLHPDGSP 610 DVAGEKGIQK 620 IPSGRTVDKL 630 EDRGRTLRSS 640 KPKDFKTEEE 650 LLSYIRENYQ 660 KTVATGEIML 670 YACARNMIST 680 VKMFLKSKGT 690 KELEVNCLNQ 700 VKSSLLKTSK 710 SLRQNLGKKL 720 DKEDKVRECQ 730 LQVFLRLEMC 740 LQCPSINEST 750 DDMEQVVEEV 760 TDLLRMVCLT 770 EDSAYLAEFL 780 EEILRLYIDS 790 IPKTLGNLYN 800 SLGFVIPQKL 810 AGVLPTDFFS 820 DDSMTQENKS 830 PLLSVPFLSS 840 ARRSVSGSPE 850 SDELQELRTR 860 SAKKRRKNAL 870 IRHKSIAEVS 880 QNLRQIEIPK 890 VSKRATKKEN 900 SHPAPQQPSQ 910 PVKDTVQEVT 920 KVRRNLFNQE 930 LLSPSKRSLK 940 RGLPRSHSVS 950 AVDGLEDKLD 960 NFKKNKGYHK 970 LLTKSVAETP 980 VHKQISKRLL 990 HRQIKGRSSD 1000 PGPDIGVVEE 1010 SPEKGDEISL 1020 RRSPRIKQLS 1030 FSRTHSASFY 1040 SVSQPKSRSV 1050 QRVHSFQQDK 1060 SDQRENSPVQ 1070 SIRSPKSLLF 1080 GAMSEMISPS 1090 EKGSARMKKR 1100 SRNTLDSEVP 1110 AAYQTPKKSH 1120 QKSLSFSKTT 1130 PRRISHTPQT 1140 PLYTPERLQK 1150 SPAKMTPTKQ 1160 AAFKESLKDS 1170 SSPGHDSPLD 1180 SKITPQKRHT 1190 QAGEGTSLET 1200 KTPRTPKRQG 1210 TQPPGFLPNC 1220 TWPHSVNSSP 1230 ESPSCPAPPT 1240 SSTAQPRREC 1250 LTPIRDPLRT 1260 PPRAAAFMGT 1270 PQNQTHQQPH 1280 VLRAARAEEP 1290 AQKLKDKAIK 1300 TPKRPGNSTV 1310 TSSPPVTPKK 1320 LFTSPLCDVS 1330 KKSPFRKSKI 1340 ECPSPGELDQ 1350 KEPQMSPSVA 1360 ASLSCPVPST 1370 PPELSQRATL 1380 DTVPPPPPSK 1390 VGKRCRKTSD 1400 PRRSIVECQP 1410 DASATPGVGT 1420 ADSPAAPTDS 1430 RDDQKGLSLS 1440 PQSPPERRGY 1450 PGPGLRSDWH 1460 ASSPLLITSD 1470 TEHVTLLSEA 1480 EHHGIGDLKS 1490 NVLSVEEGEG 1500 LRTADAEKSS 1510 LSHPGIPPSP 1520 PSCGPGSPLM 1530 PSRDVHCTTD 1540 GRQCQASAQL 1550 DNLPASAWHS 1560 TDSASPQTYE 1570 VELEMQASGL 1580 PKLRIKKIDP 1590 SSSLEAEPLS 1600 KEESSLGEES 1610 FLPALSMPRA 1620 SRSLSKPEPT 1630 YVSPPCPRLS 1640 HSTPGKSRGQ 1650 TYICQACTPT 1660 HGPSSTPSPF 1670 QTDGVPWTPS 1680 PKHSGKTTPD 1690 IIKDWPRRKR 1700 AVGCGAGSSS 1710 GRGEVGADLP 1720 GSLSLLESEG 1730 KDHGLELSIH 1740 RTPILEDFEL 1750 EGVCQLPDQS 1760 PPRNSMPKAE 1770 EASSWGQFGL 1780 SSRKRVLLAK 1790 EEADRGAKRI 1800 CDLREDSEVS 1810 KSKEGSPSWS 1820 AWQLPSTGDE 1830 EVFVSGSTPP 1840 PSCAVRSCLS 1850 ASALQALTQS 1860 PLLFQGKTPS 1870 SQSKDPRDED 1880 VDVLPSTVED 1890 SPFSRAFSRR 1900 RPISRTYTRK 1910 KLMGTWLEDL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003682 chromatin binding
Biological Process GO:0006281 DNA repair
Biological Process GO:0006260 DNA replication
Biological Process GO:0033314 mitotic DNA replication checkpoint signaling
Biological Process GO:0007095 mitotic G2 DNA damage checkpoint signaling
Biological Process GO:0030174 regulation of DNA-templated DNA replication initiation
Biological Process GO:0010212 response to ionizing radiation

Reference

PMID: N/A