Search Results
Overview
| Uniprot ID | Q7Z2Z1 |
|---|---|
| Protein Name | Treslin |
| Gene Name | TICRR |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1118 | QKSLSFSKTTPRRIS |
| 1283 | RAEEPAQKLKDKAIK |
Function
Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation
Protein Sequence
10
MACCHKVMLL
20
LDTAGGAARH
30
SRVRRAALRL
40
LTYLSCRFGL
50
ARVHWAFKFF
60
DSQGARSRPS
70
RVSDFRELGS
80
RSWEDFEEEL
90
EARLEDRAHL
100
PGPAPRATHT
110
HGALMETLLD
120
YQWDRPEITS
130
PTKPILRSSG
140
RRLLDVESEA
150
KEAEAALGGL
160
VNAVFLLAPC
170
PHSQRELLQF
180
VSGCEAQAQR
190
LPPTPKQVME
200
KLLPKRVREV
210
MVARKITFYW
220
VDTTEWSKLW
230
ESPDHLGYWT
240
VCELLHHGGG
250
TVLPSESFSW
260
DFAQAGEMLL
270
RSGIKLSSEP
280
HLSPWISMLP
290
TDATLNRLLY
300
NSPEYEASFP
310
RMEGMLFLPV
320
EAGKEIQETW
330
TVTLEPLAMH
340
QRHFQKPVRI
350
FLKGSVAQWS
360
LPTSSTLGTD
370
SWMLGSPEES
380
TATQRLLFQQ
390
LVSRLTAEEL
400
HLVADVDPGE
410
GRPPITGVIS
420
PLSASAMILT
430
VCRTKEAEFQ
440
RHVLQTAVAD
450
SPRDTASLFS
460
DVVDSILNQT
470
HDSLADTASA
480
ASPVPEWAQQ
490
ELGHTTPWSP
500
AVVEKWFPFC
510
NISGASSDLM
520
ESFGLLQAAS
530
ANKEESSKTE
540
GELIHCLAEL
550
YQRKSREEST
560
IAHQEDSKKK
570
RGVPRTPVRQ
580
KMNTMCRSLK
590
MLNVARLNVK
600
AQKLHPDGSP
610
DVAGEKGIQK
620
IPSGRTVDKL
630
EDRGRTLRSS
640
KPKDFKTEEE
650
LLSYIRENYQ
660
KTVATGEIML
670
YACARNMIST
680
VKMFLKSKGT
690
KELEVNCLNQ
700
VKSSLLKTSK
710
SLRQNLGKKL
720
DKEDKVRECQ
730
LQVFLRLEMC
740
LQCPSINEST
750
DDMEQVVEEV
760
TDLLRMVCLT
770
EDSAYLAEFL
780
EEILRLYIDS
790
IPKTLGNLYN
800
SLGFVIPQKL
810
AGVLPTDFFS
820
DDSMTQENKS
830
PLLSVPFLSS
840
ARRSVSGSPE
850
SDELQELRTR
860
SAKKRRKNAL
870
IRHKSIAEVS
880
QNLRQIEIPK
890
VSKRATKKEN
900
SHPAPQQPSQ
910
PVKDTVQEVT
920
KVRRNLFNQE
930
LLSPSKRSLK
940
RGLPRSHSVS
950
AVDGLEDKLD
960
NFKKNKGYHK
970
LLTKSVAETP
980
VHKQISKRLL
990
HRQIKGRSSD
1000
PGPDIGVVEE
1010
SPEKGDEISL
1020
RRSPRIKQLS
1030
FSRTHSASFY
1040
SVSQPKSRSV
1050
QRVHSFQQDK
1060
SDQRENSPVQ
1070
SIRSPKSLLF
1080
GAMSEMISPS
1090
EKGSARMKKR
1100
SRNTLDSEVP
1110
AAYQTPKKSH
1120
QKSLSFSKTT
1130
PRRISHTPQT
1140
PLYTPERLQK
1150
SPAKMTPTKQ
1160
AAFKESLKDS
1170
SSPGHDSPLD
1180
SKITPQKRHT
1190
QAGEGTSLET
1200
KTPRTPKRQG
1210
TQPPGFLPNC
1220
TWPHSVNSSP
1230
ESPSCPAPPT
1240
SSTAQPRREC
1250
LTPIRDPLRT
1260
PPRAAAFMGT
1270
PQNQTHQQPH
1280
VLRAARAEEP
1290
AQKLKDKAIK
1300
TPKRPGNSTV
1310
TSSPPVTPKK
1320
LFTSPLCDVS
1330
KKSPFRKSKI
1340
ECPSPGELDQ
1350
KEPQMSPSVA
1360
ASLSCPVPST
1370
PPELSQRATL
1380
DTVPPPPPSK
1390
VGKRCRKTSD
1400
PRRSIVECQP
1410
DASATPGVGT
1420
ADSPAAPTDS
1430
RDDQKGLSLS
1440
PQSPPERRGY
1450
PGPGLRSDWH
1460
ASSPLLITSD
1470
TEHVTLLSEA
1480
EHHGIGDLKS
1490
NVLSVEEGEG
1500
LRTADAEKSS
1510
LSHPGIPPSP
1520
PSCGPGSPLM
1530
PSRDVHCTTD
1540
GRQCQASAQL
1550
DNLPASAWHS
1560
TDSASPQTYE
1570
VELEMQASGL
1580
PKLRIKKIDP
1590
SSSLEAEPLS
1600
KEESSLGEES
1610
FLPALSMPRA
1620
SRSLSKPEPT
1630
YVSPPCPRLS
1640
HSTPGKSRGQ
1650
TYICQACTPT
1660
HGPSSTPSPF
1670
QTDGVPWTPS
1680
PKHSGKTTPD
1690
IIKDWPRRKR
1700
AVGCGAGSSS
1710
GRGEVGADLP
1720
GSLSLLESEG
1730
KDHGLELSIH
1740
RTPILEDFEL
1750
EGVCQLPDQS
1760
PPRNSMPKAE
1770
EASSWGQFGL
1780
SSRKRVLLAK
1790
EEADRGAKRI
1800
CDLREDSEVS
1810
KSKEGSPSWS
1820
AWQLPSTGDE
1830
EVFVSGSTPP
1840
PSCAVRSCLS
1850
ASALQALTQS
1860
PLLFQGKTPS
1870
SQSKDPRDED
1880
VDVLPSTVED
1890
SPFSRAFSRR
1900
RPISRTYTRK
1910
KLMGTWLEDL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003682 | chromatin binding |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0006260 | DNA replication |
| Biological Process | GO:0033314 | mitotic DNA replication checkpoint signaling |
| Biological Process | GO:0007095 | mitotic G2 DNA damage checkpoint signaling |
| Biological Process | GO:0030174 | regulation of DNA-templated DNA replication initiation |
| Biological Process | GO:0010212 | response to ionizing radiation |
Reference
PMID: N/A