Search Results

Overview

Uniprot ID	Q7Z2Z2
Protein Name	Elongation factor-like GTPase 1
Gene Name	EFL1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
711	MVNEEIGKQQKVAVI

Function

GTPase involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export

Protein Sequence

10 MVLNSLDKMI 20 QLQKNTANIR 30 NICVLAHVDH 40 GKTTLADCLI 50 SSNGIISSRL 60 AGKLRYMDSR 70 EDEQIRGITM 80 KSSAISLHYA 90 TGNEEYLINL 100 IDSPGHVDFS 110 SEVSTAVRIC 120 DGCIIVVDAV 130 EGVCPQTQAV 140 LRQAWLENIR 150 PVLVINKIDR 160 LIVELKFTPQ 170 EAYSHLKNIL 180 EQINALTGTL 190 FTSKVLEERA 200 ERETESQVNP 210 NSEQGEQVYD 220 WSTGLEDTDD 230 SHLYFSPEQG 240 NVVFTSAIDG 250 WGFGIEHFAR 260 IYSQKIGIKK 270 EVLMKTLWGD 280 YYINMKAKKI 290 MKGDQAKGKK 300 PLFVQLILEN 310 IWSLYDAVLK 320 KDKDKIDKIV 330 TSLGLKIGAR 340 EARHSDPKVQ 350 INAICSQWLP 360 ISHAVLAMVC 370 QKLPSPLDIT 380 AERVERLMCT 390 GSQTFDSFPP 400 ETQALKAAFM 410 KCGSEDTAPV 420 IIFVSKMFAV 430 DAKALPQNKP 440 RPLTQEEIAQ 450 RRERARQRHA 460 EKLAAAQGQA 470 PLEPTQDGSA 480 IETCPKGEEP 490 RGDEQQVESM 500 TPKPVLQEEN 510 NQESFIAFAR 520 VFSGVARRGK 530 KIFVLGPKYS 540 PLEFLRRVPL 550 GFSAPPDGLP 560 QVPHMAYCAL 570 ENLYLLMGRE 580 LEYLEEVPPG 590 NVLGIGGLQD 600 FVLKSATLCS 610 LPSCPPFIPL 620 NFEATPIVRV 630 AVEPKHPSEM 640 PQLVKGMKLL 650 NQADPCVQIL 660 IQETGEHVLV 670 TAGEVHLQRC 680 LDDLKERFAK 690 IHISVSEPII 700 PFRETITKPP 710 KVDMVNEEIG 720 KQQKVAVIHQ 730 MKEDQSKIPE 740 GIQVDSDGLI 750 TITTPNKLAT 760 LSVRAMPLPE 770 EVTQILEENS 780 DLIRSMEQLT 790 SSLNEGENTH 800 MIHQKTQEKI 810 WEFKGKLEQH 820 LTGRRWRNIV 830 DQIWSFGPRK 840 CGPNILVNKS 850 EDFQNSVWTG 860 PADKASKEAS 870 RYRDLGNSIV 880 SGFQLATLSG 890 PMCEEPLMGV 900 CFVLEKWDLS 910 KFEEQGASDL 920 AKEGQEENET 930 CSGGNENQEL 940 QDGCSEAFEK 950 RTSQKGESPL 960 TDCYGPFSGQ 970 LIATMKEACR 980 YALQVKPQRL 990 MAAMYTCDIM 1000 ATGDVLGRVY 1010 AVLSKREGRV 1020 LQEEMKEGTD 1030 MFIIKAVLPV 1040 AESFGFADEI 1050 RKRTSGLASP 1060 QLVFSHWEII 1070 PSDPFWVPTT 1080 EEEYLHFGEK 1090 ADSENQARKY 1100 MNAVRKRKGL 1110 YVEEKIVEHA 1120 EKQRTLSKNK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:1990904	ribonucleoprotein complex
Molecular Function	GO:0005525	GTP binding
Molecular Function	GO:0003924	GTPase activity
Molecular Function	GO:0043022	ribosome binding
Molecular Function	GO:0003746	translation elongation factor activity
Biological Process	GO:0042256	cytosolic ribosome assembly
Biological Process	GO:0046039	GTP metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.