Search Results
Overview
| Uniprot ID | Q7Z3B3 |
|---|---|
| Protein Name | KAT8 regulatory NSL complex subunit 1 |
| Gene Name | KANSL1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1089 | SPPIVPLKSRHLVAA |
Function
Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (PubMed:20018852, PubMed:22547026, PubMed:33657400). The NSL complex also acts as a regulator of gene expression in mitochondria (PubMed:27768893). In addition to its role in transcription, KANSL1 also plays an essential role in spindle assembly during mitosis (PubMed:26243146). Associates with microtubule ends and contributes to microtubule stability (PubMed:26243146)
Protein Sequence
10
MAAMAPALTD
20
AAAEAHHIRF
30
KLAPPSSTLS
40
PGSAENNGNA
50
NILIAANGTK
60
RKAIAAEDPS
70
LDFRNNPTKE
80
DLGKLQPLVA
90
SYLCSDVTSV
100
PSKESLKLQG
110
VFSKQTVLKS
120
HPLLSQSYEL
130
RAELLGRQPV
140
LEFSLENLRT
150
MNTSGQTALP
160
QAPVNGLAKK
170
LTKSSTHSDH
180
DNSTSLNGGK
190
RALTSSALHG
200
GEMGGSESGD
210
LKGGMTNCTL
220
PHRSLDVEHT
230
TLYSNNSTAN
240
KSSVNSMEQP
250
ALQGSSRLSP
260
GTDSSSNLGG
270
VKLEGKKSPL
280
SSILFSALDS
290
DTRITALLRR
300
QADIESRARR
310
LQKRLQVVQA
320
KQVERHIQHQ
330
LGGFLEKTLS
340
KLPNLESLRP
350
RSQLMLTRKA
360
EAALRKAASE
370
TTTSEGLSNF
380
LKSNSISEEL
390
ERFTASGIAN
400
LRCSEQAFDS
410
DVTDSSSGGE
420
SDIEEEELTR
430
ADPEQRHVPL
440
RRRSEWKWAA
450
DRAAIVSRWN
460
WLQAHVSDLE
470
YRIRQQTDIY
480
KQIRANKGLI
490
VLGEVPPPEH
500
TTDLFLPLSS
510
EVKTDHGTDK
520
LIESVSQPLE
530
NHGAPIIGHI
540
SESLSTKSCG
550
ALRPVNGVIN
560
TLQPVLADHI
570
PGDSSDAEEQ
580
LHKKQRLNLV
590
SSSSDGTCVA
600
ARTRPVLSCK
610
KRRLVRPNSI
620
VPLSKKVHRN
630
STIRPGCDVN
640
PSCALCGSGS
650
INTMPPEIHY
660
EAPLLERLSQ
670
LDSCVHPVLA
680
FPDDVPTSLH
690
FQSMLKSQWQ
700
NKPFDKIKPP
710
KKLSLKHRAP
720
MPGSLPDSAR
730
KDRHKLVSSF
740
LTTAKLSHHQ
750
TRPDRTHRQH
760
LDDVGAVPMV
770
ERVTAPKAER
780
LLNPPPPVHD
790
PNHSKMRLRD
800
HSSERSEVLK
810
HHTDMSSSSY
820
LAATHHPPHS
830
PLVRQLSTSS
840
DSPAPASSSS
850
QVTASTSQQP
860
VRRRRGESSF
870
DINNIVIPMS
880
VAATTRVEKL
890
QYKEILTPSW
900
REVDLQSLKG
910
SPDEENEEIE
920
DLSDAAFAAL
930
HAKCEEMERA
940
RWLWTTSVPP
950
QRRGSRSYRS
960
SDGRTTPQLG
970
SANPSTPQPA
980
SPDVSSSHSL
990
SEYSHGQSPR
1000
SPISPELHSA
1010
PLTPVARDTP
1020
RHLASEDTRC
1030
STPELGLDEQ
1040
SVQPWERRTF
1050
PLAHSPQAEC
1060
EDQLDAQERA
1070
ARCTRRTSGS
1080
KTGRETEAAP
1090
TSPPIVPLKS
1100
RHLVAAATAQ
RPTHR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000123 | histone acetyltransferase complex |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0071339 | MLL1 complex |
| Cellular Component | GO:0044545 | NSL complex |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0000922 | spindle pole |
| Molecular Function | GO:0035035 | histone acetyltransferase binding |
| Biological Process | GO:0006325 | chromatin organization |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:1903108 | regulation of mitochondrial transcription |
Reference
PMID: N/A