Search Results

Overview

Uniprot IDQ7Z3K3
Protein NamePogo transposable element with ZNF domain
Gene NamePOGZ
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
489 AQLTNFPKVATSFRC
687 EGLKPGTKVTIRASR
744 IQKRAVRKMSVMGRQ
871 RVHDRNVKNMYPPPS
883 PPSFPTNKAATVKSA
888 TNKAATVKSAGATPA

Function

Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed:20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed:26721387)

Protein Sequence

10 MADTDLFMEC 20 EEEELEPWQK 30 ISDVIEDSVV 40 EDYNSVDKTT 50 TVSVSQQPVS 60 APVPIAAHAS 70 VAGHLSTSTT 80 VSSSGAQNSD 90 STKKTLVTLI 100 ANNNAGNPLV 110 QQGGQPLILT 120 QNPAPGLGTM 130 VTQPVLRPVQ 140 VMQNANHVTS 150 SPVASQPIFI 160 TTQGFPVRNV 170 RPVQNAMNQV 180 GIVLNVQQGQ 190 TVRPITLVPA 200 PGTQFVKPTV 210 GVPQVFSQMT 220 PVRPGSTMPV 230 RPTTNTFTTV 240 IPATLTIRST 250 VPQSQSQQTK 260 STPSTSTTPT 270 ATQPTSLGQL 280 AVQSPGQSNQ 290 TTNPKLAPSF 300 PSPPAVSIAS 310 FVTVKRPGVT 320 GENSNEVAKL 330 VNTLNTIPSL 340 GQSPGPVVVS 350 NNSSAHGSQR 360 TSGPESSMKV 370 TSSIPVFDLQ 380 DGGRKICPRC 390 NAQFRVTEAL 400 RGHMCYCCPE 410 MVEYQKKGKS 420 LDSEPSVPSA 430 AKPPSPEKTA 440 PVASTPSSTP 450 IPALSPPTKV 460 PEPNENVGDA 470 VQTKLIMLVD 480 DFYYGRDGGK 490 VAQLTNFPKV 500 ATSFRCPHCT 510 KRLKNNIRFM 520 NHMKHHVELD 530 QQNGEVDGHT 540 ICQHCYRQFS 550 TPFQLQCHLE 560 NVHSPYESTT 570 KCKICEWAFE 580 SEPLFLQHMK 590 DTHKPGEMPY 600 VCQVCQYRSS 610 LYSEVDVHFR 620 MIHEDTRHLL 630 CPYCLKVFKN 640 GNAFQQHYMR 650 HQKRNVYHCN 660 KCRLQFLFAK 670 DKIEHKLQHH 680 KTFRKPKQLE 690 GLKPGTKVTI 700 RASRGQPRTV 710 PVSSNDTPPS 720 ALQEAAPLTS 730 SMDPLPVFLY 740 PPVQRSIQKR 750 AVRKMSVMGR 760 QTCLECSFEI 770 PDFPNHFPTY 780 VHCSLCRYST 790 CCSRAYANHM 800 INNHVPRKSP 810 KYLALFKNSV 820 SGIKLACTSC 830 TFVTSVGDAM 840 AKHLVFNPSH 850 RSSSILPRGL 860 TWIAHSRHGQ 870 TRDRVHDRNV 880 KNMYPPPSFP 890 TNKAATVKSA 900 GATPAEPEEL 910 LTPLAPALPS 920 PASTATPPPT 930 PTHPQALALP 940 PLATEGAECL 950 NVDDQDEGSP 960 VTQEPELASG 970 GGGSGGVGKK 980 EQLSVKKLRV 990 VLFALCCNTE 1000 QAAEHFRNPQ 1010 RRIRRWLRRF 1020 QASQGENLEG 1030 KYLSFEAEEK 1040 LAEWVLTQRE 1050 QQLPVNEETL 1060 FQKATKIGRS 1070 LEGGFKISYE 1080 WAVRFMLRHH 1090 LTPHARRAVA 1100 HTLPKDVAEN 1110 AGLFIDFVQR 1120 QIHNQDLPLS 1130 MIVAIDEISL 1140 FLDTEVLSSD 1150 DRKENALQTV 1160 GTGEPWCDVV 1170 LAILADGTVL 1180 PTLVFYRGQM 1190 DQPANMPDSI 1200 LLEAKESGYS 1210 DDEIMELWST 1220 RVWQKHTACQ 1230 RSKGMLVMDC 1240 HRTHLSEEVL 1250 AMLSASSTLP 1260 AVVPAGCSSK 1270 IQPLDVCIKR 1280 TVKNFLHKKW 1290 KEQAREMADT 1300 ACDSDVLLQL 1310 VLVWLGEVLG 1320 VIGDCPELVQ 1330 RSFLVASVLP 1340 GPDGNINSPT 1350 RNADMQEELI 1360 ASLEEQLKLS 1370 GEHSESSTPR 1380 PRSSPEETIE 1390 PESLHQLFEG 1400 ESETESFYGF 1410 EEADLDLMEI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003700 DNA-binding transcription factor activity
Molecular Function GO:0000976 transcription cis-regulatory region binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0051301 cell division
Biological Process GO:0000724 double-strand break repair via homologous recombination
Biological Process GO:0051382 kinetochore assembly
Biological Process GO:0007064 mitotic sister chromatid cohesion
Biological Process GO:0006355 regulation of DNA-templated transcription

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.