Search Results
Overview
| Uniprot ID | Q7Z434 |
|---|---|
| Protein Name | Mitochondrial antiviral-signaling protein |
| Gene Name | MAVS |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 348 | LTNPAPSKLPINSTR |
| 362 | RAGMVPSKVPTSMVL |
Function
Adapter required for innate immune defense against viruses (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:21170385, PubMed:23087404, PubMed:27992402, PubMed:33139700, PubMed:37582970, PubMed:39589880, PubMed:38995016). Acts downstream of DHX33, RIGI and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFNB and RANTES (CCL5) (PubMed:16125763, PubMed:16127453, PubMed:16153868, PubMed:16177806, PubMed:19631370, PubMed:20127681, PubMed:20451243, PubMed:20628368, PubMed:21170385, PubMed:23087404, PubMed:25636800, PubMed:27736772, PubMed:33110251, PubMed:40042308). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (PubMed:20451243). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response (PubMed:20451243). May activate the same pathways following detection of extracellular dsRNA by TLR3 (PubMed:16153868). May protect cells from apoptosis (PubMed:16125763). Involved in NLRP3 inflammasome activation by mediating NLRP3 recruitment to mitochondria (PubMed:23582325)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0031966 | mitochondrial membrane |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0032760 | positive regulation of tumor necrosis factor production |
| Biological Process | GO:0032481 | positive regulation of type I interferon production |
| Biological Process | GO:0060340 | positive regulation of type I interferon-mediated signaling pathway |
| Biological Process | GO:0070585 | protein localization to mitochondrion |
| Biological Process | GO:0051262 | protein tetramerization |
| Biological Process | GO:1900063 | regulation of peroxisome organization |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0060337 | type I interferon-mediated signaling pathway |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005778 | peroxisomal membrane |
| Molecular Function | GO:0050700 | CARD domain binding |
| Molecular Function | GO:0140297 | DNA-binding transcription factor binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0060090 | molecular adaptor activity |
| Molecular Function | GO:0140693 | molecular condensate scaffold activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0120283 | protein serine/threonine kinase binding |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Molecular Function | GO:0035591 | signaling adaptor activity |
| Biological Process | GO:0002218 | activation of innate immune response |
| Biological Process | GO:0140374 | antiviral innate immune response |
| Biological Process | GO:0071360 | cellular response to exogenous dsRNA |
| Biological Process | GO:0035458 | cellular response to interferon-beta |
| Biological Process | GO:0002753 | cytoplasmic pattern recognition receptor signaling pathway |
| Biological Process | GO:0042742 | defense response to bacterium |
| Biological Process | GO:0051607 | defense response to virus |
| Biological Process | GO:0045087 | innate immune response |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0045071 | negative regulation of viral genome replication |
| Biological Process | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0071651 | positive regulation of chemokine (C-C motif) ligand 5 production |
| Biological Process | GO:0002230 | positive regulation of defense response to virus by host |
| Biological Process | GO:0032727 | positive regulation of interferon-alpha production |
| Biological Process | GO:0032728 | positive regulation of interferon-beta production |
| Biological Process | GO:0032755 | positive regulation of interleukin-6 production |
| Biological Process | GO:0032757 | positive regulation of interleukin-8 production |
| Biological Process | GO:0071660 | positive regulation of IP-10 production |
| Biological Process | GO:0002735 | positive regulation of myeloid dendritic cell cytokine production |
| Biological Process | GO:1900227 | positive regulation of NLRP3 inflammasome complex assembly |
| Biological Process | GO:0042307 | positive regulation of protein import into nucleus |
| Biological Process | GO:0060760 | positive regulation of response to cytokine stimulus |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.