Search Results
Overview
| Uniprot ID | Q7Z460 |
|---|---|
| Protein Name | CLIP-associating protein 1 |
| Gene Name | CLASP1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 541 | KALQSHLKNSDSIVS |
Function
Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle
Protein Sequence
10
MEPRMESCLA
20
QVLQKDVGKR
30
LQVGQELIDY
40
FSDKQKSADL
50
EHDQTMLDKL
60
VDGLATSWVN
70
SSNYKVVLLG
80
MDILSALVTR
90
LQDRFKAQIG
100
TVLPSLIDRL
110
GDAKDSVREQ
120
DQTLLLKIMD
130
QAANPQYVWD
140
RMLGGFKHKN
150
FRTREGICLC
160
LIATLNASGA
170
QTLTLSKIVP
180
HICNLLGDPN
190
SQVRDAAINS
200
LVEIYRHVGE
210
RVRADLSKKG
220
LPQSRLNVIF
230
TKFDEVQKSG
240
NMIQSANDKN
250
FDDEDSVDGN
260
RPSSASSTSS
270
KAPPSSRRNV
280
GMGTTRRLGS
290
STLGSKSSAA
300
KEGAGAVDEE
310
DFIKAFDDVP
320
VVQIYSSRDL
330
EESINKIREI
340
LSDDKHDWEQ
350
RVNALKKIRS
360
LLLAGAAEYD
370
NFFQHLRLLD
380
GAFKLSAKDL
390
RSQVVREACI
400
TLGHLSSVLG
410
NKFDHGAEAI
420
MPTIFNLIPN
430
SAKIMATSGV
440
VAVRLIIRHT
450
HIPRLIPVIT
460
SNCTSKSVAV
470
RRRCFEFLDL
480
LLQEWQTHSL
490
ERHISVLAET
500
IKKGIHDADS
510
EARIEARKCY
520
WGFHSHFSRE
530
AEHLYHTLES
540
SYQKALQSHL
550
KNSDSIVSLP
560
QSDRSSSSSQ
570
ESLNRPLSAK
580
RSPTGSTTSR
590
ASTVSTKSVS
600
TTGSLQRSRS
610
DIDVNAAASA
620
KSKVSSSSGT
630
TPFSSAAALP
640
PGSYASLGRI
650
RTRRQSSGSA
660
TNVASTPDNR
670
GRSRAKVVSQ
680
SQRSRSANPA
690
GAGSRSSSPG
700
KLLGSGYGGL
710
TGGSSRGPPV
720
TPSSEKRSKI
730
PRSQGCSRET
740
SPNRIGLARS
750
SRIPRPSMSQ
760
GCSRDTSRES
770
SRDTSPARGF
780
PPLDRFGLGQ
790
PGRIPGSVNA
800
MRVLSTSTDL
810
EAAVADALKK
820
PVRRRYEPYG
830
MYSDDDANSD
840
ASSVCSERSY
850
GSRNGGIPHY
860
LRQTEDVAEV
870
LNHCASSNWS
880
ERKEGLLGLQ
890
NLLKSQRTLS
900
RVELKRLCEI
910
FTRMFADPHS
920
KRVFSMFLET
930
LVDFIIIHKD
940
DLQDWLFVLL
950
TQLLKKMGAD
960
LLGSVQAKVQ
970
KALDVTRDSF
980
PFDQQFNILM
990
RFIVDQTQTP
1000
NLKVKVAILK
1010
YIESLARQMD
1020
PTDFVNSSET
1030
RLAVSRIITW
1040
TTEPKSSDVR
1050
KAAQIVLISL
1060
FELNTPEFTM
1070
LLGALPKTFQ
1080
DGATKLLHNH
1090
LKNSSNTSVG
1100
SPSNTIGRTP
1110
SRHTSSRTSP
1120
LTSPTNCSHG
1130
GLSPSRLWGW
1140
SADGLAKHPP
1150
PFSQPNSIPT
1160
APSHKALRRS
1170
YSPSMLDYDT
1180
ENLNSEEIYS
1190
SLRGVTEAIE
1200
KFSFRSQEDL
1210
NEPIKRDGKK
1220
ECDIVSRDGG
1230
AASPATEGRG
1240
GSEVEGGRTA
1250
LDNKTSLLNT
1260
QPPRAFPGPR
1270
ARDYNPYPYS
1280
DAINTYDKTA
1290
LKEAVFDDDM
1300
EQLRDVPIDH
1310
SDLVADLLKE
1320
LSNHNERVEE
1330
RKGALLELLK
1340
ITREDSLGVW
1350
EEHFKTILLL
1360
LLETLGDKDH
1370
SIRALALRVL
1380
REILRNQPAR
1390
FKNYAELTIM
1400
KTLEAHKDSH
1410
KEVVRAAEEA
1420
ASTLASSIHP
1430
EQCIKVLCPI
1440
IQTADYPINL
1450
AAIKMQTKVV
1460
ERIAKESLLQ
1470
LLVDIIPGLL
1480
QGYDNTESSV
1490
RKASVFCLVA
1500
IYSVIGEDLK
1510
PHLAQLTGSK
1520
MKLLNLYIKR
1530
AQTTNSNSSS
SSDVSTHS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0045180 | basal cortex |
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0031592 | centrosomal corona |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0030981 | cortical microtubule cytoskeleton |
| Cellular Component | GO:0005881 | cytoplasmic microtubule |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000776 | kinetochore |
| Cellular Component | GO:0005828 | kinetochore microtubule |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005815 | microtubule organizing center |
| Cellular Component | GO:0035371 | microtubule plus-end |
| Cellular Component | GO:0072686 | mitotic spindle |
| Cellular Component | GO:0005876 | spindle microtubule |
| Molecular Function | GO:0002162 | dystroglycan binding |
| Molecular Function | GO:0043515 | kinetochore binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0051010 | microtubule plus-end binding |
| Biological Process | GO:0030953 | astral microtubule organization |
| Biological Process | GO:0071711 | basement membrane organization |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0040001 | establishment of mitotic spindle localization |
| Biological Process | GO:0051294 | establishment of spindle orientation |
| Biological Process | GO:0007163 | establishment or maintenance of cell polarity |
| Biological Process | GO:0010458 | exit from mitosis |
| Biological Process | GO:0007030 | Golgi organization |
| Biological Process | GO:0034453 | microtubule anchoring |
| Biological Process | GO:0001578 | microtubule bundle formation |
| Biological Process | GO:0000226 | microtubule cytoskeleton organization |
| Biological Process | GO:0007020 | microtubule nucleation |
| Biological Process | GO:0031023 | microtubule organizing center organization |
| Biological Process | GO:0090307 | mitotic spindle assembly |
| Biological Process | GO:0007052 | mitotic spindle organization |
| Biological Process | GO:0007026 | negative regulation of microtubule depolymerization |
| Biological Process | GO:0031111 | negative regulation of microtubule polymerization or depolymerization |
| Biological Process | GO:0051497 | negative regulation of stress fiber assembly |
| Biological Process | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells |
| Biological Process | GO:0010634 | positive regulation of epithelial cell migration |
| Biological Process | GO:0045921 | positive regulation of exocytosis |
| Biological Process | GO:0090091 | positive regulation of extracellular matrix disassembly |
| Biological Process | GO:0031116 | positive regulation of microtubule polymerization |
| Biological Process | GO:0051893 | regulation of focal adhesion assembly |
| Biological Process | GO:0006903 | vesicle targeting |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.