Search Results
Overview
| Uniprot ID | Q7Z4G4 |
|---|---|
| Protein Name | tRNA (guanine(10)-N(2))-methyltransferase TRMT11 |
| Gene Name | TRMT11 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 111 | SDSTYKIKIHTFNKT |
| 332 | EIPKGIEKWEKCPES |
| 452 | KYFSGVTKRIAKEEK |
Function
Catalytic subunit of the TRMT11-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 10 (m2G10) in tRNAs (PubMed:37283053). This is one of the major tRNA (guanine-N(2))-methyltransferases (PubMed:37283053)
Protein Sequence
10
MALSCTLNRY
20
LLLMAQEHLE
30
FRLPEIKSLL
40
LLFGGQFASS
50
QETYGKSPFW
60
ILSIPSEDIA
70
RNLMKRTVCA
80
KSIFELWGHG
90
QSPEELYSSL
100
KNYPVEKMVP
110
FLHSDSTYKI
120
KIHTFNKTLT
130
QEEKIKRIDA
140
LEFLPFEGKV
150
NLKKPQHVFS
160
VLEDYGLDPN
170
CIPENPHNIY
180
FGRWIADGQR
190
ELIESYSVKK
200
RHFIGNTSMD
210
AGLSFIMANH
220
GKVKENDIVF
230
DPFVGTGGLL
240
IACAHFGAYV
250
YGTDIDYNTV
260
HGLGKATRKN
270
QKWRGPDENI
280
RANLRQYGLE
290
KYYLDVLVSD
300
ASKPSWRKGT
310
YFDAIITDPP
320
YGIRESTRRT
330
GSQKEIPKGI
340
EKWEKCPESH
350
VPVSLSYHLS
360
DMFLDLLNFA
370
AETLVLGGRL
380
VYWLPVYTPE
390
YTEEMVPWHP
400
CLELVSNCEQ
410
KLSSHTSRRL
420
ITMEKVKKFE
430
NRDQYSHLLS
440
DHFLPYQGHN
450
SFREKYFSGV
460
TKRIAKEEKS
TQE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0043528 | tRNA (m2G10) methyltransferase complex |
| Molecular Function | GO:0008168 | methyltransferase activity |
| Molecular Function | GO:0160102 | tRNA (guanine(10)-N2)-methyltransferase activity |
| Molecular Function | GO:0000049 | tRNA binding |
| Biological Process | GO:0001510 | RNA methylation |
| Biological Process | GO:0008033 | tRNA processing |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.