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Overview

Uniprot ID	Q7Z4Q2
Protein Name	HEAT repeat-containing protein 3
Gene Name	HEATR3
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
339	HKRRVRRKTFVSDLL

Function

Plays a role in ribosome biogenesis and in nuclear import of the 60S ribosomal protein L5/large ribosomal subunit protein uL18 (RPL5) (PubMed:35213692). Required for proper erythrocyte maturation (PubMed:35213692)

Protein Sequence

10 MGKSRTKRFK 20 RPQFSPTGDC 30 QAEAAAAANG 40 TGGEEDDGPA 50 AELLEKLQHP 60 SAEVRECACA 70 GLARLVQQRP 80 ALPGLARRDA 90 VRRLGPLLLD 100 PSLAVRETAA 110 GALRNLSACG 120 GFEVCDDMVT 130 KDIMTPLVAL 140 LKECSAGLDS 150 NEMSLQEKKD 160 QNRNSIENIA 170 NETVNVLWNI 180 CECSSRAVSI 190 FNKEGCLEIV 200 LKYLSRFPTN 210 VDLAISVAYC 220 LQTVTEDNPE 230 LLKSFSATAL 240 NMLESALLSP 250 VSSMESLLLK 260 TLVAGTIWNL 270 KDIIPCKSQA 280 EIINALLKIL 290 SEVLGMDAGE 300 MVIQMKEAET 310 QRLKTAAEAE 320 EILENTNGDD 330 LIEDDEMEGI 340 SHKRRVRRKT 350 FVSDLLPPTD 360 KELRETIALL 370 TAQQTALEII 380 VNMCCNEDPS 390 DDEWEELSSS 400 DESDAFMENS 410 FSECGGQLFS 420 PLCLSHEVHT 430 ALTNYLIPKK 440 IFEKTAFPNS 450 IAVDLCSRNP 460 TWKPLIRKMN 470 TIQCRALFCL 480 QSLVSLLDVE 490 HLGGAAALQT 500 LAQHLSQLLF 510 SQPDFAKHVD 520 FLEAISSALR 530 ALLQTMASKN 540 ISQCMTPDQL 550 MTLCKAGIHS 560 SNVGVRVNVV 570 SILGITGSVL 580 AKEDGTLETL 590 KNIGCFLLEV 600 TTKDPSLVVA 610 GEALDALFDV 620 FADGKEAERA 630 SIQIKLLSAL 640 KEFQPVFKMK 650 IRKEGRGNYS 660 TDQLCVLDNV 670 KMNLRRFIAY 680 QETVEKRLTS

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:0051082	unfolded protein binding
Biological Process	GO:0043249	erythrocyte maturation
Biological Process	GO:0006606	protein import into nucleus
Biological Process	GO:0042273	ribosomal large subunit biogenesis

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.