Search Results

Overview

Uniprot ID	Q7Z4S6
Protein Name	Kinesin-like protein KIF21A
Gene Name	KIF21A
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1088	QLLFHMLKEKAELNP
754	KNQSQYEKQLKKLQQ

Function

Processive microtubule plus-end directed motor protein involved in neuronal axon guidance. Is recruited by KANK1 to cortical microtubule stabilizing complexes (CMSCs) at focal adhesions (FAs) rims where it promotes microtubule capture and stability. Controls microtubule polymerization rate at axonal growth cones and suppresses microtubule growth without inducing microtubule disassembly once it reaches the cell cortex

Protein Sequence

10 MLGAPDESSV 20 RVAVRIRPQL 30 AKEKIEGCHI 40 CTSVTPGEPQ 50 VFLGKDKAFT 60 FDYVFDIDSQ 70 QEQIYIQCIE 80 KLIEGCFEGY 90 NATVFAYGQT 100 GAGKTYTMGT 110 GFDVNIVEEE 120 LGIISRAVKH 130 LFKSIEEKKH 140 IAIKNGLPAP 150 DFKVNAQFLE 160 LYNEEVLDLF 170 DTTRDIDAKS 180 KKSNIRIHED 190 STGGIYTVGV 200 TTRTVNTESE 210 MMQCLKLGAL 220 SRTTASTQMN 230 VQSSRSHAIF 240 TIHVCQTRVC 250 PQIDADNATD 260 NKIISESAQM 270 NEFETLTAKF 280 HFVDLAGSER 290 LKRTGATGER 300 AKEGISINCG 310 LLALGNVISA 320 LGDKSKRATH 330 VPYRDSKLTR 340 LLQDSLGGNS 350 QTIMIACVSP 360 SDRDFMETLN 370 TLKYANRARN 380 IKNKVMVNQD 390 RASQQINALR 400 SEITRLQMEL 410 MEYKTGKRII 420 DEEGVESIND 430 MFHENAMLQT 440 ENNNLRVRIK 450 AMQETVDALR 460 SRITQLVSDQ 470 ANHVLARAGE 480 GNEEISNMIH 490 SYIKEIEDLR 500 AKLLESEAVN 510 ENLRKNLTRA 520 TARAPYFSGS 530 STFSPTILSS 540 DKETIEIIDL 550 AKKDLEKLKR 560 KEKRKKKRLQ 570 KLEESNREER 580 SVAGKEDNTD 590 TDQEKKEEKG 600 VSERENNELE 610 VEESQEVSDH 620 EDEEEEEEEE 630 EDDIDGGESS 640 DESDSESDEK 650 ANYQADLANI 660 TCEIAIKQKL 670 IDELENSQKR 680 LQTLKKQYEE 690 KLMMLQHKIR 700 DTQLERDQVL 710 QNLGSVESYS 720 EEKAKKVRSE 730 YEKKLQAMNK 740 ELQRLQAAQK 750 EHARLLKNQS 760 QYEKQLKKLQ 770 QDVMEMKKTK 780 VRLMKQMKEE 790 QEKARLTESR 800 RNREIAQLKK 810 DQRKRDHQLR 820 LLEAQKRNQE 830 VVLRRKTEEV 840 TALRRQVRPM 850 SDKVAGKVTR 860 KLSSSDAPAQ 870 DTGSSAAAVE 880 TDASRTGAQQ 890 KMRIPVARVQ 900 ALPTPATNGN 910 RKKYQRKGLT 920 GRVFISKTAR 930 MKWQLLERRV 940 TDIIMQKMTI 950 SNMEADMNRL 960 LKQREELTKR 970 REKLSKRREK 980 IVKENGEGDK 990 NVANINEEME 1000 SLTANIDYIN 1010 DSISDCQANI 1020 MQMEEAKEEG 1030 ETLDVTAVIN 1040 ACTLTEARYL 1050 LDHFLSMGIN 1060 KGLQAAQKEA 1070 QIKVLEGRLK 1080 QTEITSATQN 1090 QLLFHMLKEK 1100 AELNPELDAL 1110 LGHALQDLDS 1120 VPLENVEDST 1130 DEDAPLNSPG 1140 SEGSTLSSDL 1150 MKLCGEVKPK 1160 NKARRRTTTQ 1170 MELLYADSSE 1180 LASDTSTGDA 1190 SLPGPLTPVA 1200 EGQEIGMNTE 1210 TSGTSAREKE 1220 LSPPPGLPSK 1230 IGSISRQSSL 1240 SEKKIPEPSP 1250 VTRRKAYEKA 1260 EKSKAKEQKH 1270 SDSGTSEASL 1280 SPPSSPPSRP 1290 RNELNVFNRL 1300 TVSQGNTSVQ 1310 QDKSDESDSS 1320 LSEVHRSSRR 1330 GIINPFPASK 1340 GIRAFPLQCI 1350 HIAEGHTKAV 1360 LCVDSTDDLL 1370 FTGSKDRTCK 1380 VWNLVTGQEI 1390 MSLGGHPNNV 1400 VSVKYCNYTS 1410 LVFTVSTSYI 1420 KVWDIRDSAK 1430 CIRTLTSSGQ 1440 VTLGDACSAS 1450 TSRTVAIPSG 1460 ENQINQIALN 1470 PTGTFLYAAS 1480 GNAVRMWDLK 1490 RFQSTGKLTG 1500 HLGPVMCLTV 1510 DQISSGQDLI 1520 ITGSKDHYIK 1530 MFDVTEGALG 1540 TVSPTHNFEP 1550 PHYDGIEALT 1560 IQGDNLFSGS 1570 RDNGIKKWDL 1580 TQKDLLQQVP 1590 NAHKDWVCAL 1600 GVVPDHPVLL 1610 SGCRGGILKV 1620 WNMDTFMPVG 1630 EMKGHDSPIN 1640 AICVNSTHIF 1650 TAADDRTVRI 1660 WKARNLQDGQ 1670 ISDTGDLGED IASN

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:1904115	axon cytoplasm
Cellular Component	GO:0044295	axonal growth cone
Cellular Component	GO:0005938	cell cortex
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0030425	dendrite
Cellular Component	GO:0005871	kinesin complex
Cellular Component	GO:0005874	microtubule
Cellular Component	GO:0098793	presynapse
Molecular Function	GO:0071532	ankyrin repeat binding
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0008017	microtubule binding
Molecular Function	GO:0003777	microtubule motor activity
Molecular Function	GO:0008574	plus-end-directed microtubule motor activity
Biological Process	GO:0008089	anterograde axonal transport
Biological Process	GO:0043622	cortical microtubule organization
Biological Process	GO:0007018	microtubule-based movement
Biological Process	GO:1902667	regulation of axon guidance
Biological Process	GO:0031114	regulation of microtubule depolymerization
Biological Process	GO:0031113	regulation of microtubule polymerization

Reference

[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.