Search Results

Overview

Uniprot IDQ7Z4V5
Protein NameHepatoma-derived growth factor-related protein 2
Gene NameHDGFL2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
16 DLVFAKMKGYPHWPA
163 KRKTPALKMSVSKRA
168 ALKMSVSKRARKASS
286 PAEKPLPKPRGRKPK
414 REAKKSAKKPQSSST
415 EAKKSAKKPQSSSTE
439 KRVRPEEKQQAKPVK
446 KQQAKPVKVERTRKR
466 MDRKVEKKKEPSVEE
554 KSRVLGPKIEAVQKV
560 PKIEAVQKVNKAGME
563 EAVQKVNKAGMEKEK

Function

Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (PubMed:32459350). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (PubMed:32459350). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (PubMed:26721387). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (PubMed:26721387, PubMed:32459350). Involved in cellular growth control, through the regulation of cyclin D1 expression (PubMed:25689719)

Protein Sequence

10 MPHAFKPGDL 20 VFAKMKGYPH 30 WPARIDDIAD 40 GAVKPPPNKY 50 PIFFFGTHET 60 AFLGPKDLFP 70 YDKCKDKYGK 80 PNKRKGFNEG 90 LWEIQNNPHA 100 SYSAPPPVSS 110 SDSEAPEANP 120 ADGSDADEDD 130 EDRGVMAVTA 140 VTATAASDRM 150 ESDSDSDKSS 160 DNSGLKRKTP 170 ALKMSVSKRA 180 RKASSDLDQA 190 SVSPSEEENS 200 ESSSESEKTS 210 DQDFTPEKKA 220 AVRAPRRGPL 230 GGRKKKKAPS 240 ASDSDSKADS 250 DGAKPEPVAM 260 ARSASSSSSS 270 SSSSDSDVSV 280 KKPPRGRKPA 290 EKPLPKPRGR 300 KPKPERPPSS 310 SSSDSDSDEV 320 DRISEWKRRD 330 EARRRELEAR 340 RRREQEEELR 350 RLREQEKEEK 360 ERRRERADRG 370 EAERGSGGSS 380 GDELREDDEP 390 VKKRGRKGRG 400 RGPPSSSDSE 410 PEAELEREAK 420 KSAKKPQSSS 430 TEPARKPGQK 440 EKRVRPEEKQ 450 QAKPVKVERT 460 RKRSEGFSMD 470 RKVEKKKEPS 480 VEEKLQKLHS 490 EIKFALKVDS 500 PDVKRCLNAL 510 EELGTLQVTS 520 QILQKNTDVV 530 ATLKKIRRYK 540 ANKDVMEKAA 550 EVYTRLKSRV 560 LGPKIEAVQK 570 VNKAGMEKEK 580 AEEKLAGEEL 590 AGEEAPQEKA 600 EDKPSTDLSA 610 PVNGEATSQK 620 GESAEDKEHE 630 EGRDSEEGPR 640 CGSSEDLHDS 650 VREGPDLDRP 660 GSDRQERERA 670 RGDSEALDEE S

Gene Ontology

Classification GO ID Description
Biological Process GO:0030307 positive regulation of cell growth
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0061628 histone H3K27me3 reader activity
Molecular Function GO:0062072 histone H3K9me2/3 reader activity
Molecular Function GO:0140566 histone reader activity
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0006310 DNA recombination
Biological Process GO:0006281 DNA repair
Biological Process GO:0140861 DNA repair-dependent chromatin remodeling
Biological Process GO:0042692 muscle cell differentiation
Biological Process GO:0007517 muscle organ development
Biological Process GO:1905168 positive regulation of double-strand break repair via homologous recombination
Biological Process GO:0043403 skeletal muscle tissue regeneration

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[5] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[6] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[7] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[8] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[9] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[10] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[11] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.