Search Results

Overview

Uniprot IDQ7Z4W1
Protein NameL-xylulose reductase
Gene NameDCXR
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
153 HSVYCSTKGALDMLT
161 GALDMLTKVMALELG
17 VLVTGAGKGIGRGTV
171 ALELGPHKIRVNAVN
196 ATWSDPHKAKTMLNR
198 WSDPHKAKTMLNRIP

Function

Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose (PubMed:11882650, PubMed:19337691, PubMed:40737316). Can use both NAD and NADP as cosubstrate but shows higher activity with NADP (PubMed:11882650). Participates in the uronate cycle of glucose metabolism (PubMed:11882650). May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules (PubMed:11882650)

Protein Sequence

10 MELFLAGRRV 20 LVTGAGKGIG 30 RGTVQALHAT 40 GARVVAVSRT 50 QADLDSLVRE 60 CPGIEPVCVD 70 LGDWEATERA 80 LGSVGPVDLL 90 VNNAAVALLQ 100 PFLEVTKEAF 110 DRSFEVNLRA 120 VIQVSQIVAR 130 GLIARGVPGA 140 IVNVSSQCSQ 150 RAVTNHSVYC 160 STKGALDMLT 170 KVMALELGPH 180 KIRVNAVNPT 190 VVMTSMGQAT 200 WSDPHKAKTM 210 LNRIPLGKFA 220 EVEHVVNAIL 230 FLLSDRSGMT 240 TGSTLPVEGG FWAC

Gene Ontology

Classification GO ID Description
Cellular Component GO:0001669 acrosomal vesicle
Cellular Component GO:0016324 apical plasma membrane
Cellular Component GO:0005903 brush border
Cellular Component GO:0005881 cytoplasmic microtubule
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005902 microvillus
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0004090 carbonyl reductase (NADPH) activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0050038 L-xylulose reductase (NADPH) activity
Molecular Function GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
Biological Process GO:0019640 D-glucuronate catabolic process to D-xylulose 5-phosphate
Biological Process GO:0042732 D-xylose metabolic process
Biological Process GO:0006006 glucose metabolic process
Biological Process GO:2000379 positive regulation of reactive oxygen species metabolic process
Biological Process GO:0005997 xylulose metabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.