Overview
| Uniprot ID | Q7Z4Y8 |
|---|
| Protein Name | ATP synthase subunit g 2, mitochondrial |
|---|
| Gene Name | ATP5MGL |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 54 |
PRAIQSLKKIVSSAQ |
Function
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity)
Protein Sequence
10
MAPFVRNLVE
20
KTPALVNAAV
30
TYLKPRLAAF
40
WYYTTVELVP
50
PTPAEIPRAI
60
QSLKKIVSSA
70
QTGSFKQLTV
80
KEALLNGLVA
90
TEVSTWFYVR
100
EITGKRGIIG
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0045259 |
proton-transporting ATP synthase complex |
| Molecular Function |
GO:0015078 |
proton transmembrane transporter activity |
| Biological Process |
GO:0015986 |
proton motive force-driven ATP synthesis |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.