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Overview

Uniprot IDQ7Z589
Protein NameBRCA2-interacting transcriptional repressor EMSY
Gene NameEMSY
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1003 QLSIRHQKLTPLQQE
467 TQQVQPSKILPKPVT
587 VVQKTTGKGTTIQGL
655 AAKIIPTKIVYGQQG

Function

Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338)

Protein Sequence

10 MPVVWPTLLD 20 LSRDECKRIL 30 RKLELEAYAG 40 VISALRAQGD 50 LTKEKKDLLG 60 ELSKVLSIST 70 ERHRAEVRRA 80 VNDERLTTIA 90 HNMSGPNSSS 100 EWSIEGRRLV 110 PLMPRLVPQT 120 AFTVTANAVA 130 NAAIQHNASL 140 PVPAETGSKE 150 VVCYSYTSTT 160 STPTSTPVPS 170 GSIATVKSPR 180 PASPASNVVV 190 LPSGSTVYVK 200 SVSCSDEDEK 210 PRKRRRTNSS 220 SSSPVVLKEV 230 PKAVVPVSKT 240 ITVPVSGSPK 250 MSNIMQSIAN 260 SLPPHMSPVK 270 ITFTKPSTQT 280 TNTTTQKVII 290 VTTSPSSTFV 300 PNILSKSHNY 310 AAVTKLVPTS 320 VIASTTQKPP 330 VVITASQSSL 340 VSNSSSGSSS 350 STPSPIPNTV 360 AVTAVVSSTP 370 SVVMSTVAQG 380 VSTSAIKMAS 390 TRLPSPKSLV 400 SAPTQILAQF 410 PKQHQQSPKQ 420 QLYQVQQQTQ 430 QQVAQPSPVS 440 HQQQPQQSPL 450 PPGIKPTIQI 460 KQESGVKIIT 470 QQVQPSKILP 480 KPVTATLPTS 490 SNSPIMVVSS 500 NGAIMTTKLV 510 TTPTGTQATY 520 TRPTVSPSIG 530 RMAATPGAAT 540 YVKTTSGSII 550 TVVPKSLATL 560 GGKIISSNIV 570 SGTTTKITTI 580 PMTSKPNVIV 590 VQKTTGKGTT 600 IQGLPGKNVV 610 TTLLNAGGEK 620 TIQTVPTGAK 630 PAILTATRPI 640 TKMIVTQPKG 650 IGSTVQPAAK 660 IIPTKIVYGQ 670 QGKTQVLIKP 680 KPVTFQATVV 690 SEQTRQLVTE 700 TLQQASRVAE 710 AGNSSIQEGK 720 EEPQNYTDSS 730 SSSTESSQSS 740 QDSQPVVHVI 750 ASRRQDWSEH 760 EIAMETSPTI 770 IYQDVSSESQ 780 SATSTIKALL 790 ELQQTTVKEK 800 LESKPRQPTI 810 DLSQMAVPIQ 820 MTQEKRHSPE 830 SPSIAVVESE 840 LVAEYITTER 850 TDEGTEVAFP 860 LLVSHRSQPQ 870 QPSQPQRTLL 880 QHVAQSQTAT 890 QTSVVVKSIP 900 ASSPGAITHI 910 MQQALSSHTA 920 FTKHSEELGT 930 EEGEVEEMDT 940 LDPQTGLFYR 950 SALTQSQSAK 960 QQKLSQPPLE 970 QTQLQVKTLQ 980 CFQTKQKQTI 990 HLQADQLQHK 1000 LPQMPQLSIR 1010 HQKLTPLQQE 1020 QAQPKPDVQH 1030 TQHPMVAKDR 1040 QLPTLMAQPP 1050 QTVVQVLAVK 1060 TTQQLPKLQQ 1070 APNQPKIYVQ 1080 PQTPQSQMSL 1090 PASSEKQTAS 1100 QVEQPIITQG 1110 SSVTKITFEG 1120 RQPPTVTKIT 1130 GGSSVPKLTS 1140 PVTSISPIQA 1150 SEKTAVSDIL 1160 KMSLMEAQID 1170 TNVEHMIVDP 1180 PKKALATSML 1190 TGEAGSLPST 1200 HMVVAGMANS 1210 TPQQQKCRES 1220 CSSPSTVGSS 1230 LTTRKIDPPA 1240 VPATGQFMRI 1250 QNVGQKKAEE 1260 SPAEIIIQAI 1270 PQYAIPCHSS 1280 SNVVVEPSGL 1290 LELNNFTSQQ 1300 LDDEETAMEQ 1310 DIDSSTEDGT 1320 EPSPSQSSAE RS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0042802 identical protein binding
Biological Process GO:0006325 chromatin organization
Biological Process GO:0006281 DNA repair
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0006355 regulation of DNA-templated transcription

Reference

[1] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.